Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

Cited by (212)

Items 101–200 of 212

  1. Glial Cells in Alzheimer’s Disease: Pathogenic Mechanisms and Therapeutic Frontiers
    Moumita Sil, Nabanita Mukherjee, Ishita Chatterjee, Ankita Ghosh, Arunava Goswami · 2025 · Journal of Molecular Neuroscience
  2. Targeting Microglial Activation to Modulate Neuroinflammation in Alzheimer’s Disease
    Vinay Patil, Amit Sharma, Bhavin K Parekh, Husni Farah, S. Renuka Jyothi, Swati Smaranika Mishra, Anima Nanda, Shaker Al-Hasnaawei, Manoj Kumar Mishra · 2025 · NeuroMolecular Medicine
  3. Sterile innate immune mechanisms in neurodegenerative diseases
    Alyssa Ealy, Amanda M Serapiglia, Nikhil Panicker · 2025 · Journal of Biological Chemistry
  4. miR-26a-5p/ADAM17-Mediated Proteolysis of TREM2 Regulates Neuroinflammation in Hypertensive Mice Following Lead Exposure
    Yuran Wang, Zeming Wang, Han Hao, Yuwei Zhao, Jian Wang, Weixuan Wang · 2025 · Toxics
  5. Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response
    Naseeb Kaur Malhi, Yingjun Luo, Xiaofang Tang, Rahuljeet Singh Chadha, Alonso Tapia, Dongqiang Yuan, Shufan Yin, Xuejing Liu, Muxi Chen, Meirigeng Qi et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  6. PU.1 dictates β-amyloid-induced TREM2 expression upregulation in microglia in a transgenic model of Alzheimer’s disease
    Wei, Zhen, Pan, Xiaodong, Cui, Xiaoli, Zhang, Jing, Dai, Xiaoman, Zeng, Yuqi, Chen, Xiaochun · 2025 · Frontiers in Aging Neuroscience
  7. Celastrol Ameliorated Alzheimer’s Disease in Mice by Enhancing TBX21/TREM2 Expression in Microglia and Inhibiting Tau Phosphorylation
    Fanfan Cao, Pan Zhang, Yongbin Chi, Ying Wang, Limin Xu, Denghai Zhang · 2025 · Neurochemical Research
  8. Safety and efficacy evaluation of intracerebroventricular human neural stem cell transplantation in SOD1 mice as a novel approach for ALS
    Ivan Lombardi, Clelia Ferrero, Edvige Vulcano, Daniela Maria Rasà, Maurizio Gelati, Diego Pastor, Rose Mary Carletti, Silvia de la Morena, Daniela Celeste Profico, Sabrina Longobardi et al. · 2025 · Journal of Translational Medicine
  9. Beyond Neuroinflammation: Microglia at the Crossroads of Amyloid, Tau, and Neurodegeneration in Alzheimer’s Disease
    Rasoul Ebrahimi, Sanaz Bordbar, Ghazal Azad, Samin Davoody, MahSima Mahmoudi, Khadijeh Esmaeilpour · 2025 · Neurological Sciences
  10. TREM2-driven peripheral macrophage regulation in inflammatory diseases: implications extending beyond neurological disorders
    Xiaohui Zhou, Zenghui Liu, Shuaiyi Li, Yu Song, Mingshuang Sun, Zihou Si, Wei Zhu · 2025 · Inflammation Research
  11. Innate neuroimmunity across aging and neurodegeneration: a perspective from amyloidogenic evolvability
    Gilbert J. Ho, Linh Q. Lam, Tony T. Tran, Jianshe Wei, Makoto Hashimoto · 2024 · Frontiers in Cell and Developmental Biology
  12. Prenatal drivers of microglia vulnerability in the adult
    Erica Tagliatti, Matteo Bizzotto, Raffaella Morini, Fabia Filipello, Marco Rasile, Michela Matteoli · 2024 · Immunological Reviews
  13. Validation of stable reference genes in peripheral blood mononuclear cells for expression studies involving vector-borne haemoparasitic diseases in bovines
    Rashmeet Kaur, Sonika Ahlawat, Vikas Choudhary · 2023 · Ticks and Tick-borne Diseases
  14. Comprehensive investigation of the expression profiles of common long noncoding RNAs during microglial activation
    Janghyun Kim, Bora Lee, Byeong Chae Kim, Joon‐Tae Kim, Joon‐Tae Kim, Hyong‐Ho Cho · 2023 · Genomics & Informatics
  15. Translational regulation and protein-coding capacity of the 5′ untranslated region of human TREM2
    Motoaki Yanaizu, Haruka Adachi, Makoto Araki, Kenji Kontani, Yoshihiro Kino · 2023 · Communications Biology
  16. Choroidal Neovascularization Is Suppressed With Activation of TREM2 in Mononuclear Phagocytes—Brief Report
    Hitomi Yagi, Myriam Boeck, Katherine Neilsen, Jay Yang, Minji Ko, Yohei Tomita, Kazuno Negishi, Zhongjie Fu, Ye Sun, Lois E. H. Smith · 2025 · Arteriosclerosis Thrombosis and Vascular Biology
  17. Ms4a4a deficiency ameliorates plaque pathology in a mouse model of amyloid accumulation
    Emma Danhash, Anthony C. Verbeck, Daniel Western, Andrea S. Díaz‐Pacheco, Grant Galasso, Shih‐Feng You, Guangming Huang, Emma Starr, Nadia Miller, Collin J. Nadarajah et al. · 2025 · Alzheimer s & Dementia
  18. Navigation Between Alzheimer’s Disease (AD) and Its Various Pathophysiological Trajectories: The Pathogenic Link to Neuroimmunology—Genetics and Neuroinflammation
    Abdalla Bowirrat, Albert Pinhasov, Aia Bowirrat, Rajendra Dhar Badgaiyan · 2025 · International Journal of Molecular Sciences
  19. Interleukin-4-Mediated NLRP3 Inflammasome Activation in Microglia Contributes to Allergic Rhinitis via Central Sensitization
    Hao Lv, Yunfei Wang, Lu Tan · 2025 · Research
  20. TREM2-mediated neuroinflammatory response is involved in AgNPs-induced ferroptosis in HMC3 cells
    Haitao Yang, Menghao Guo, Shuyan Niu, Chenyu Liu, Tianshu Wu, Mengjing Cui, Yuying Xue · 2025 · NeuroToxicology
  21. The main signaling pathways determining the microglia responses in spinal cord injury: Potential effectors among known pharmaceuticals
    Elvira Ruslanovna Akhmetzyanova, Albert Anatolyevich Rizvanov, Yana Olegovna Mukhamedshina · 2025 · Experimental Neurology
  22. Shared genes and pathways in dementia: Insights from genome‐wide association studies
    Kyle J. Loi, Noah Radtke, Chloe Kiriluk, Mohamed H. Noureldein, Eva L. Feldman, Kelly M. Bakulski, Kevin S. Chen · 2025 · Alzheimer s & Dementia
  23. The Role of TREM2 After Stroke: From Mechanisms to Therapeutic Potential
    Tong Zhou, Anqi Chen, Yuanyuan Sun, Bo Huang, Ying Xu, Quanwei He · 2025 · Molecular Neurobiology
  24. The superiority and feasibility of 2,3,5‐triphenyltetrazolium chloride–stained brain tissues for molecular biology experiments based on microglial properties
    Yajuan Wang, Qingrong Zhang, Shuchi Zhang, Jiangtao Qi, Li Li · 2023 · Animal Models and Experimental Medicine
  25. TREM2 coding variants in Slovak Alzheimer's disease patients
    Vladimı́ra Ďurmanová, Juraj Javor, Zuzana Párnická, Gabriel Minárik, Agata Ocenasova, Barbora Vašečková, Iliana Kiralyova, Stanislav Šutovský, Róbert Petrovič, Ivana Shawkatová · 2022 · Journal of Integrative Neuroscience
  26. The TREM2 H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine Release
    Xinxin Fu, Shuaiyu Chen, Hui-Wen Lian, Yang Deng, Rui Duan, Yingdong Zhang, Teng Jiang · 2023 · Brain Sciences
  27. Genetic variability associated with OAS1 expression in myeloid cells increases the risk of Alzheimer’s disease and severe COVID-19 outcomes
    Naciye Magusali, Andrew C. Graham, Thomas M. Piers, Pantila Panichnantakul, Ümran Yaman, Maryam Shoai, Regina Hertfelder Reynolds, Juan Antonio Botía, Keeley J. Brookes, Tamar Guetta‐Baranes et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  28. Dysregulated Resolution of Inflammation After Respiratory Viral Infections: Molecular Pathways Linking Neuroinflammation to Post-Viral Neuropathic Pain—A Narrative Review
    Andrei Emilian Popa, Elena Popa, Tatiana Dramba, Adorata Elena Coman, Mihaela Poroch, Monica Iuliana Ungureanu, Agnes Iacinta Bacușcă, Ana Maria Slănină, Gema Bacoanu, Vladimir Poroch · 2025 · International Journal of Molecular Sciences
  29. Immuno‐Regulation of Brain Region‐Specific Organoids Containing Isogenic Microglia‐Like Cells
    Chang Liu, Justice Ene, Wenyan Lü, Falak Syed, Li Jun Sun, Ana‐Caroline Raulin, Yi Ren, Xueju Sophie Wang, Takahisa Kanekiyo, Yan Li · 2025 · Advanced Healthcare Materials
  30. Advances in research on the complement system and cognitive impairment
    Jie Gao, Zhe Li, Xinyue Zhang, Wenshu Huang, Zhiyu Tian, Chuyu Xiao, Yuanyang Zhen, Fang Yu, Xuezhao Cao · 2026 · Immunobiology
  31. Synthetic cleavage-resistant TREM2 boosts macrophage efferocytosis to treat inflammatory diseases
    Xianghui Dong, Xiaotian Zhao, Jinxin Gao, Longyu Bo, Yan Li, Zhichao Kong, 孙维绎, Xinxin Xu, Zhanyan Liu, Qirui Xiu et al. · 2026 · Cell Reports Medicine
  32. Role Shift of Glial Cells from Physiology to Pathology in Alzheimer’s Disease: The Regulatory Impact of Exercise
    Runze Liu, Qianting Deng, Li Gong, Luodan Yang · 2026 · Neuroscience Bulletin
  33. Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease
    Henna Martiskainen, Roosa-Maria Willman, Sami Heikkinen, Stephan A. Müller, Rosa Sinisalo, Mari Takalo, Petra M. Mäkinen, Teemu Kuulasmaa, Viivi Pekkala, Ana Galván del Rey et al. · 2024 · medRxiv
  34. TREM2 signaling pathway in sepsis-induced acute lung injury: physiology, pathology, and therapeutic applications
    Honglei Shen, Jing He, Fei Lin · 2025 · Frontiers in Medicine
  35. Comparing Mediterranean and Western Diets: Cognitive and Microbiota Effects in Middle-Aged Rats
    Rebecca J. Solch-Ottaiano, Colin Harper, Madison Prats, Elizabeth B. Engler-Chiurazzi, Blake Ouvrier, Saifudeen Ismael, Gregory Jaye Bix, Demetrius M. Maraganore · 2025 · Current Developments in Nutrition
  36. Parkinson’s disease: spatiotemporal regulation and therapeutic prospects of TREM2-mediated microglial responses
    Keyuan Hou, Zhaowu An, Yuxiang Xu, Jing Wang, Meiru Zhou, Ye Liu, Xianfeng Zhu, Jianshe Wei · 2026 · npj Parkinson s Disease
  37. The temporal and stimuli-specific effects of LPS and IFNγ on microglial activation
    Christina N. Heiss, Andrew S. Naylor, Ida Pesämaa, Arketa Meshi, Benjamín Cespedes-Cortes, Chiméne Lounès, Ayat Taki, Katarina Türner-Stenström, Dzeneta Vizlin‐Hodzic, Henrik Zetterberg et al. · 2026 · Frontiers in Aging Neuroscience
  38. Targeting TREM2+tumor-associated macrophages reactivates antitumor immunity and improves anti-PD-1 efficacy in gastric cancer
    Tianwei Xu, Anwei Xue, Chao Lin · 2026 · Seminars in Oncology
  39. Plasma TREM2 Levels, Alcohol Consumption, and Liver Enzymes in Patients with Alcohol use Disorder: A Sex-Dependent Relationship Involving MS4A6A Genetic Polymorphism
    Ming‐Fen Ho, Cheng Zhang, Brandon J. Coombes, Joanna M. Biernacka, Michelle K. Skime, Paul E. Croarkin, Tyler Oesterle, Victor M. Karpyak, Hu Li, Richard M. Weinshilboum · 2025 · Journal of Proteomics and Genomics research
  40. Menopause triggers microglia-associated neuroinflammation in Parkinson’s disease
    Said Usman, Amal Chandra Mondal · 2025 · Brain Research
  41. Interleukin 1β receptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1
    Roberto Piacentini, Claudio Grassi · 2024 · Neural Regeneration Research
  42. Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease
    James R. Evans, Melissa Grant‐Peters, Joseph S. Beckwith, Christina E. Toomey, Rebeka Popovic, Jonathan C. Breiter, Jonathan Brenton, Aine Fairbrother-Browne, Stephanie Strohbuecker, Joanne Lachica et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Amyloid‐Related Imaging Abnormality (ARIA) Beyond the APOE‐ε4 Allele
    Valentinus Besin, Farizky Martriano Humardani, Fenny Lanawati Yudiarto, Paulus Anam Ong, Sulistyo Emantoko Dwi Putra, Ratih Asmana Ningrum · 2025 · Chronic Diseases and Translational Medicine
  44. Mechanisms of Innate Immune Modulation by High-Fat Diet: Implications for Obesity and Asthma
    Heather L. Caslin, Jesse W. Williams · 2025 · Current Allergy and Asthma Reports
  45. Co-regulation of microglial subgroups in Alzheimer’s amyloid pathology: Implications for diagnosis and drug development
    Yu Zhou, Yukuan Huang, Yangchang Fan, Feng Xue · 2025 · PLoS ONE
  46. The role of DAP12 in immune-related inflammatory diseases
    Jiaqi Lu, Lihao Shi, Guiyuan Jin, Yonghong Yang, Fengqin Zhu, Guangxi Zhou · 2026 · Inflammation Research
  47. TREM-1 as a Potential Coreceptor in Norovirus Pathogenesis: Insights from Transcriptomic Analysis and Molecular Docking
    Mike Contreras, Amanda de Oliveira Matos, Pedro Henrique dos Santos Dantas, José Rodrigues do Carmo Neto, Bruno Junior Neves, Luiz Gustavo Gardinassi, Marcelle Silva‐Sales, Helioswilton Sales‐Campos · 2025 · ACS Omega
  48. How would preclinical Alzheimer’s disease (AD pathology) occur? An insight from a genomic instability mouse model
    Chinthalapally V. Rao, Hiroshi Y. Yamada · 2021 · Neural Regeneration Research
  49. Identifying selection signatures for immune response and resilience to Aleutian disease in mink using genotype data
    Guoyu Hu, Duy Ngoc Do, Ghader Manafiazar, Alyson A. Kelvin, Mehdi Sargolzaei, Graham Stuart Plastow, Zhiquan Wang, Pourya Davoudi, Younes Miar · 2024 · Frontiers in Genetics
  50. Chronic alcohol consumption induces phenotypic and functional alterations consistent with a hyper-inflammatory state in peripheral blood mononuclear cell-derived microglia in a rhesus macaque model
    Hamed Hemati, Madison B. Blanton, Heather True, Jude Koura, Rupak Khadka, Kathleen A. Grant, Ilhem Messaoudi · 2025 · Brain Behavior and Immunity
  51. The roles of microglia and astrocytes in inflammasomes and neurological disorders
    Yuze Xia, Yimin Huang, Yuan Liu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Chunshui Yu, Chao Gan, Huaqiu Zhang · 2025 · Neural Regeneration Research
  52. Macrophage dynamics and the role of TREM2 at the oral mucosal barrier
    Taiana C. Leite, Jiamiao Chen, Alexander Diacou, Sangmin Park, Andrew H. Jheon, Jie Yin, Quinn T. Easter, Nicholas Francis Fitz, Kevin M. Byrd, Daniel R. Clark · 2025 · Journal of Translational Medicine
  53. Microglial TREM2 deficiency causes E/I imbalance and triggers ASD-like behaviors by altering potassium channel Kv1.3 activation
    Yaping Wang, Qiushi Wang, Rongfang Li, Youxin Yu, Feng Shi, Wen Wu, Siqiang Ren · 2025 · Neurobiology of Disease
  54. Impaired TGFβ Signaling in Plaque-Associated Microglia
    Oliver Krzyzan, Angela Kuhla, Björn Spittau, Natascha Vidovic · 2026 · Biomolecules
  55. Brain-targeted delivery of siRNA via non-viral delivery systems, the therapeutic strategy for Alzheimer's disease—Unveiling challenges and prospects
    Lili Gu, Jiayi Liu, Can Wang, Xiaoqin Shan, Siyi Li, Xinyue Zhang, Lijie Xia, Jinyao Li · 2026 · International Journal of Pharmaceutics X
  56. Behavioral deficits and exacerbated neural and hemodynamic odor responses during lifespan of a mouse model of late onset Alzheimer’s disease expressing humanized APOEε4 and Trem2*R47H
    Misha izydorczak, Maggie Oumov, Mansiben V. Udhwani, Faysal Fostok, Guillermo Coronas‐Samano, Basavaraju G. Sanganahalli, Péter Hermán, Fahmeed Hyder, Justus Valentijn Verhagen · 2026 · Frontiers in Aging Neuroscience
  57. Environmental enrichment modulates chronic poststroke inflammation and links white matter TREM2‐positive microglia in recovery in mice
    Lluís Camprubí-Ferrer, Ömer K. Kolbay, Miriana Jlenia Quattromani, Tadeusz W. Wieloch, Karsten Ruscher, Tomas Deierborg · 2026 · Neuroprotection/Neuroprotection (Chichester, England. Print)
  58. Cholecalciferol (vitamin D3) is an agonist of the Alzheimer's disease–associated immune receptor TREM2
    Hunter B. Dean, Ryan A. Tuckey, Rory A. Greer, Jessica A. Greven, Shan-Zhong Yang, Daniel S. Elston, Gunnar N. Eastep, Yuwei Song, Tom J. Brett, Yuhua Song et al. · 2026 · Neurotherapeutics
  59. TREM2 as a possible link between Alzheimer's disease and diabetes mellitus
    Wendan Chen, Nanqu Huang, Wendi Huang, Mei Wang, Yong Luo, Juan Huang · 2026 · Experimental Neurology
  60. Correlation of serum glial fibrillary acidic protein (GFAP) and soluble triggering receptor expressed on myeloid cells-2 (sTREM-2) levels with disability and clinical characteristics in multiple sclerosis
    Sanaz Khodadadi, Nasim Rezaeimanesh, Tarlan Varzandi, Ali Rezaei, Majid Hamidi, Reyhaneh Montazeri‐Shatouri, Mahsa Mohammadi Lapevandani, Mohammad Ali Sahraian, Abdorreza Naser Moghadasi · 2026 · Acta Neurologica Belgica
  61. Clinical considerations for immune dysregulation and immunodeficiency in Down syndrome
    Melissa D. Gans, Juanita Valdes Camacho, Matthew Wyke, Kasama Manothummetha, Harry Layton Lesmana, Jacqueline D. Squire, Joao Pedro Matias Lopes, Erica G. Schmitt, Hanadys Ale, Junghee J. Shin et al. · 2026 · Journal of Human Immunity
  62. Epigenomic and transcriptomic differences between low-grade and acute inflammation in LPS-induced murine immune cells
    Lynette B. Naler, Yuan-Pang Hsieh, Shuo Geng, Zirui Zhou, Liwu Li, Chang Lu · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  63. Rare Variant Aggregation in 148,508 Exomes Identifies Genes Associated with Proxy Alzheimer’s disease/Dementia
    Douglas P. Wightman, Jeanne E. Savage, Christiaan de Leeuw, Iris E. Jansen, Danielle Posthuma B · 2021 · medRxiv
  64. Identification of Sulfavant A as the First Synthetic TREM2 Ligand Discloses a Homeostatic Response of Dendritic Cells After Receptor Engagement
    Carmela Gallo, Emiliano Manzo, Giusi Barra, Laura Fioretto, Marcello Ziaco, Genoveffa Nuzzo, Giuliana d’Ippolito, Francesca Ferrera, Paola Contini, Daniela Castiglia et al. · 2022 · Research Square
  65. Amelioration of signalling deficits underlying metabolic shortfall in TREM2 R47H human iPSC-derived microglia
    Foteini Vasilopoulou, Thomas M. Piers, Jingzhang Wei, John Hardy, Jennifer M. Pocock · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  66. KOLF2.1J iTF-Microglia: A standardized platform to study microglial transcriptional regulatory networks in CNS disease
    Iván Rodríguez-Nunez, Samuel C. Bartley, Jared W. Taylor, S. Quinn Johnston, Brianne B. Rogers, Sarah Kristen Meadows, Kimberly M. Newberry, J. Nicholas Cochran, R Myers · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Fus depleted oligodendrocytes reduce neuronal damage and attenuate AD progression in the App NL-G-F mouse
    Te-Hsuan Tung, Sudhagar Babu, Xiangting Tang, Alec Sciutto, Micah A. Romer, Prathima Racha, Victoria M. Fiesler, Adrita Saha, Takashi Saito, Takaomi C. Saido et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  68. The Role of Microglial-Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) in Neuronal Homeostasis and Tau Pathogenesis
    Vaishnavi Jadhav · 2021 · IUScholarWorks (Indiana University)
  69. Upregulation of Trem2 expression occurs exclusively on microglial contact with plaques
    Jack I. Wood, Eugenia Wong, Ridwaan Joghee, Aya Balbaa, Karina S. Vitanova, Alison VanSchoiack, Stefan-Laural J. Phelan, Francesca Launchbury, Sneha Desai, Takshashila Tripathi et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  70. Continuous injection of high-dose lipopolysaccharide modulates microglia polarization via TREM2 to alter the status of septic mice
    Zhiyun Qiu, Huilin Wang, Mengdi Qu, Shuainan Zhu, Hao Zhang, Qingwu Liao, Changhong Miao · 2022 · Research Square
  71. Targeting TREM2 to disrupt the mitochondrial lipid and iron metabolism in cisplatin-resistant gastric cancer cells
    Rui Wang, Quanquan Guo, Meimei Ma, Xiaohong Shi · 2023 · Research Square
  72. Avaliação do papel do TGF-ß1 e da microglia na resposta inflamatória hipotalâmica induzida por ácidos graxos saturados
    Natália Ferreira Mendes · 2021
  73. Additional file 10 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
    Rong Li, Jing Zhang, Qiong Wang, Meng Cheng, Bin Lin · 2022 · Figshare
  74. Sodium channel inhibitors alter the progress of tangle development in a mouse model of dementia
    Chloe M. Hall, Martha Roberts, Roshni A. Desai, Damian M. Cummings, Jamie Bilsland, Paul John Whiting, Kenneth J. Smith, Frances A. Edwards · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  75. Challenges and promises in optimising a non-clinical protocol of intracerebroventricular human neural stem cell transplantation in ALS
    Ivan Lombardi, Clelia Ferrero, Edvige Vulcano, Daniela Maria Rasà, Maurizio Gelati, Diego Pastor Campos, Rose Mary Carletti, Silvia de la Morena, Daniela Celeste Profico, Sabrina Longobardi et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  76. Human amyotrophic lateral sclerosis/motor neuron disease: The disease-associated microglial pathway is upregulated and APOE ε2 is protective
    Bridget Ashford, Julie E. Simpson, Charlotte Dawson, Delphine Boche, Johnathan Cooper‐Knock, Paul Roy Heath, Daniel J. Fillingham, Charlie Appleby‐Mallinder, Wenbin Wei, Mark Dunning et al. · 2025 · medRxiv
  77. Ms4a4a deficiency ameliorates plaque pa thology in a mouse model of amyloid accumulation
    Emma Danhash, Anthony C. Verbeck, Daniel Western et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  78. Behavioral deficits and exacerbated hemodynamics during lifespan of a mouse model of late onset Alzheimer’s disease expressing humanized APOEε4 and Trem2*R47H
    Misha izydorczak, Maggie Oumov, Mansiben V. Udhwani, Faysal Fostok, Guillermo Coronas‐Samano, Basavaraju G. Sanganahalli, Péter Hermán, Fahmeed Hyder, Justus Valentijn Verhagen · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  79. Dysfunction of microglia-mediated synaptic pruning in Autism spectrum disorder
    Chen Yu, Xiao‐Peng Zhang, Wei Wang · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  80. The Microglial Trem2 R47H Alzheimer’s Disease Risk Variant Does Not Detectably Alter Hippocampal Synaptic Transmission in Young Mice
    Abdulaziz Isa Aljawder, Hedaythul Choudhury, Damian M. Cummings, Jack I. Wood, Frances A. Edwards · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  81. Trem2 prevents adverse pregnancy outcomes induced by Toxoplasma gondii by promoting PPARγ-mediated P-STAT6 signaling
    Yining Cao, Xinyue Wang, Zhiqing Zhang, Ming-Yan Shi, Tian Ming, Mei Yang, Jinling Chen · 2025 · International Immunopharmacology
  82. RNA sequencing and bioinformatics analysis of tissue biopsy of abdominal fat in obesity associated with cardio-metabolic diseases
    Basavaraj Mallikarjunayya Vastrad, Chanabasayya Mallikarjunayya Vastrad · 2025 · Research Square
  83. Alzheimer’s Disease: Pathophysiological and Therapeutical Insights
    Komal Tyagi, Prerna Sarup, Jai Malik · 2025 · Nutritional neurosciences
  84. The unexpected dual role of S100A9 amyloid protein on neurodegeneration in progressive multiple sclerosis motor cortex
    Jonathan Pansieri, Jonathan Atwood, Marco Pisa, Richard L. Yates, Gabriele C. DeLuca · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  85. Additional file 3 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
    Rong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
  86. Additional file 5 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
    Rong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
  87. Additional file 1 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
    Rong Li, Zhang, Jing, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
  88. Additional file 7 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
    Rong Li, Zhang, Jing, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
  89. Additional file 4 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
    Rong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
  90. Additional file 2 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
    Rong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
  91. Additional file 9 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
    Rong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
  92. Additional file 1 of Characterizing dysregulations via cell-cell communications in Alzheimer’s brains using single-cell transcriptomes
    Lee, Che Yu, Dylan Riffle, Xiong, Yifeng, Nadia Momtaz, Yutong Lei, Joseph M Pariser, Diptanshu Sikdar, Ahyeon Hwang, Ziheng Duan, Zhang, Jing · 2024 · Figshare
  93. Additional file 8 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
    Rong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
  94. Additional file 6 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway
    Rong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
  95. Additional file 1 of iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype
    Sullivan, Michael A., Lane, Samuel D., André D. J. McKenzie, Sarah R. Ball, Sunde, Margaret, Neely, G. Gregory, Moreno, Cesar L., Alexandra Maximova, Eryn L. Werry, Michael Kassiou · 2024 · Figshare
  96. A Joint Tau Propagation and Neuroinflammation Model Reinforces Inflammatory Modulation of Network-Driven Spread in Alzheimer’s Disease
    Ishaan Dhaliwal, Robin Sandell, Ashish Raj · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  97. Increased CD33 levels tune activation and function of induced human microglial cells through inhibition of the TREM2 pathway
    Amr Omer, Smita Jagtap, Elga Morrison, Lauren M. Carito, Alexander Lee Prinzen, Stefan I. McDonough, Benjamin J. Andreone · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  98. Microglial efferocytosis dysfunction contributes to depression-like behaviors and cognitive impairment in aged mice following chronic sleep deprivation.
    Man Wang, Xiaoyan Zhu, Wei Han, Shi-Ji Deng, Hong Wei, Ming Yu, Yu-Hao Xu · 2026 · Journal of Affective Disorders
  99. Targeting TREM2 to disentangle neuroinflammation and α-Syn pathological propagation in Parkinson's disease
    Yixu Chen, Hao Wang, Jun Wang, Jianshe Wei · 2026 · Cellular Signalling
  100. In vitro and in vivo study of the effects of Levetiracetam on activated microglia during sepsis
    Renaud Fleurance · 2021 · theses.fr (ABES)