Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions
Liu, Wenfei, Taso, Orjona, Wang, Rui, Bayram, Sevinc, Graham, Andrew C, Garcia-Reitboeck, Pablo, Mallach, Anna, Andrews, William D, Piers, Thomas M, Botia, Juan A, Pocock, Jennifer M, Cummings, Damian M, Hardy, John, Edwards, Frances A, Salih, Dervis A·2020·Human Molecular Genetics
Cited by (212)
Items 101–200 of 212
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- The TREM2 H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine ReleaseXinxin Fu, Shuaiyu Chen, Hui-Wen Lian, Yang Deng, Rui Duan, Yingdong Zhang, Teng Jiang · 2023 · Brain Sciences
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- Comparing Mediterranean and Western Diets: Cognitive and Microbiota Effects in Middle-Aged RatsRebecca J. Solch-Ottaiano, Colin Harper, Madison Prats, Elizabeth B. Engler-Chiurazzi, Blake Ouvrier, Saifudeen Ismael, Gregory Jaye Bix, Demetrius M. Maraganore · 2025 · Current Developments in Nutrition
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- The temporal and stimuli-specific effects of LPS and IFNγ on microglial activationChristina N. Heiss, Andrew S. Naylor, Ida Pesämaa, Arketa Meshi, Benjamín Cespedes-Cortes, Chiméne Lounès, Ayat Taki, Katarina Türner-Stenström, Dzeneta Vizlin‐Hodzic, Henrik Zetterberg et al. · 2026 · Frontiers in Aging Neuroscience
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- Plasma TREM2 Levels, Alcohol Consumption, and Liver Enzymes in Patients with Alcohol use Disorder: A Sex-Dependent Relationship Involving MS4A6A Genetic PolymorphismMing‐Fen Ho, Cheng Zhang, Brandon J. Coombes, Joanna M. Biernacka, Michelle K. Skime, Paul E. Croarkin, Tyler Oesterle, Victor M. Karpyak, Hu Li, Richard M. Weinshilboum · 2025 · Journal of Proteomics and Genomics research
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- Interleukin 1β receptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1Roberto Piacentini, Claudio Grassi · 2024 · Neural Regeneration Research
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- Behavioral deficits and exacerbated neural and hemodynamic odor responses during lifespan of a mouse model of late onset Alzheimer’s disease expressing humanized APOEε4 and Trem2*R47HMisha izydorczak, Maggie Oumov, Mansiben V. Udhwani, Faysal Fostok, Guillermo Coronas‐Samano, Basavaraju G. Sanganahalli, Péter Hermán, Fahmeed Hyder, Justus Valentijn Verhagen · 2026 · Frontiers in Aging Neuroscience
- Environmental enrichment modulates chronic poststroke inflammation and links white matter TREM2‐positive microglia in recovery in miceLluís Camprubí-Ferrer, Ömer K. Kolbay, Miriana Jlenia Quattromani, Tadeusz W. Wieloch, Karsten Ruscher, Tomas Deierborg · 2026 · Neuroprotection/Neuroprotection (Chichester, England. Print)
- Cholecalciferol (vitamin D3) is an agonist of the Alzheimer's disease–associated immune receptor TREM2Hunter B. Dean, Ryan A. Tuckey, Rory A. Greer, Jessica A. Greven, Shan-Zhong Yang, Daniel S. Elston, Gunnar N. Eastep, Yuwei Song, Tom J. Brett, Yuhua Song et al. · 2026 · Neurotherapeutics
- TREM2 as a possible link between Alzheimer's disease and diabetes mellitusWendan Chen, Nanqu Huang, Wendi Huang, Mei Wang, Yong Luo, Juan Huang · 2026 · Experimental Neurology
- Correlation of serum glial fibrillary acidic protein (GFAP) and soluble triggering receptor expressed on myeloid cells-2 (sTREM-2) levels with disability and clinical characteristics in multiple sclerosisSanaz Khodadadi, Nasim Rezaeimanesh, Tarlan Varzandi, Ali Rezaei, Majid Hamidi, Reyhaneh Montazeri‐Shatouri, Mahsa Mohammadi Lapevandani, Mohammad Ali Sahraian, Abdorreza Naser Moghadasi · 2026 · Acta Neurologica Belgica
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- Epigenomic and transcriptomic differences between low-grade and acute inflammation in LPS-induced murine immune cellsLynette B. Naler, Yuan-Pang Hsieh, Shuo Geng, Zirui Zhou, Liwu Li, Chang Lu · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Rare Variant Aggregation in 148,508 Exomes Identifies Genes Associated with Proxy Alzheimer’s disease/DementiaDouglas P. Wightman, Jeanne E. Savage, Christiaan de Leeuw, Iris E. Jansen, Danielle Posthuma B · 2021 · medRxiv
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- Upregulation of Trem2 expression occurs exclusively on microglial contact with plaquesJack I. Wood, Eugenia Wong, Ridwaan Joghee, Aya Balbaa, Karina S. Vitanova, Alison VanSchoiack, Stefan-Laural J. Phelan, Francesca Launchbury, Sneha Desai, Takshashila Tripathi et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
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- Additional file 10 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathwayRong Li, Jing Zhang, Qiong Wang, Meng Cheng, Bin Lin · 2022 · Figshare
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- Behavioral deficits and exacerbated hemodynamics during lifespan of a mouse model of late onset Alzheimer’s disease expressing humanized APOEε4 and Trem2*R47HMisha izydorczak, Maggie Oumov, Mansiben V. Udhwani, Faysal Fostok, Guillermo Coronas‐Samano, Basavaraju G. Sanganahalli, Péter Hermán, Fahmeed Hyder, Justus Valentijn Verhagen · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
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- Additional file 3 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathwayRong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
- Additional file 5 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathwayRong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
- Additional file 1 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathwayRong Li, Zhang, Jing, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
- Additional file 7 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathwayRong Li, Zhang, Jing, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
- Additional file 4 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathwayRong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
- Additional file 2 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathwayRong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
- Additional file 9 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathwayRong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
- Additional file 1 of Characterizing dysregulations via cell-cell communications in Alzheimer’s brains using single-cell transcriptomesLee, Che Yu, Dylan Riffle, Xiong, Yifeng, Nadia Momtaz, Yutong Lei, Joseph M Pariser, Diptanshu Sikdar, Ahyeon Hwang, Ziheng Duan, Zhang, Jing · 2024 · Figshare
- Additional file 8 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathwayRong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
- Additional file 6 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathwayRong Li, Jing Zhang, Wang, Qiong, Cheng, Meng, Bin Lin · 2022 · Figshare
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