The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Age-associated alteration of gene expression patterns in mouse oocytes
Abstract
Decreasing oocyte competence with maternal aging is a major factor in human infertility. To investigate the age-dependent molecular changes in a mouse model, we compared the expression profiles of metaphase II oocytes collected from 5- to 6-week-old mice with those collected from 42- to 45-week-old mice using the NIA 22K 60-mer oligo microarray. Among approximately 11,000 genes whose transcripts were detected in oocytes, about 5% (530) showed statistically significant expression changes, excluding the possibility of global decline in transcript abundance. Consistent with the generally accepted view of aging, the differentially expressed genes included ones involved in mitochondrial function and oxidative stress. However, the expression of other genes involved in chromatin structure, DNA methylation, genome stability and RNA helicases was also altered, suggesting the existence of additional mechanisms for aging. Among the transcripts decreased with aging, we identified and characterized a group of new oocyte-specific genes, members of the human NACHT, leucine-rich repeat and PYD-containing (NALP) gene family. These results have implications for aging research as well as for clinical ooplasmic donation to rejuvenate aging oocytes.
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Cites
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BackgroundBmi1, stem cells, and senescence regulation
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Cited by
Epigenetic regulation of ageing: linking environmental inputs to genomic stability
Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4048 · Cited by 610
Maternal control of early mouse development
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Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients
Kobayashi, H., Sato, A., Otsu, E., Hiura, H., Tomatsu, C., Utsunomiya, T., Sasaki, H., Yaegashi, N., & Arima, T. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm187 · Cited by 420
Aberrant DNA methylation of imprinted loci in superovulated oocytes
Sato, A., Otsu, E., Negishi, H., Utsunomiya, T., & Arima, T. (2007) · Human Reproduction · doi:10.1093/humrep/del316 · Cited by 369
Could oxidative stress influence the in-vitro maturation of oocytes?
Combelles, C. M., Gupta, S., & Agarwal, A. (2009) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60038-7 · Cited by 313
Metadata
- Authors
- Hamatani, T., Falco, G., Carter, M. G., Akutsu, H., Stagg, C. A., Sharov, A. A., Dudekula, D. B., VanBuren, V., & Ko, M. S. H.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-08-18
- Volume
- 13
- Issue
- 19
- Pages
- 2263-2278
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2110194655
- Cited by
- 519
- References
- 5
- FWCI
- 15.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hamatani, T., Falco, G., Carter, M. G., Akutsu, H., Stagg, C. A., Sharov, A. A., Dudekula, D. B., VanBuren, V., & Ko, M. S. H. (2004). Age-associated alteration of gene expression patterns in mouse oocytes. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddh241
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