The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
Open accessAbstract
Prenatal famine in humans has been associated with various later-life consequences, depending on the gestational timing of the insult and the sex of the exposed individual. Epigenetic mechanisms have been proposed to underlie these associations. Indeed, animal studies and our early human data on the imprinted IGF2 locus indicated a link between prenatal nutritional and DNA methylation. However, it remains unclear how common changes in DNA methylation are and whether they are sex- and timing-specific paralleling the later-life consequences of prenatal famine exposure. To this end, we investigated the methylation of 15 loci implicated in growth and metabolic disease in individuals who were prenatally exposed to a war-time famine in 1944-45. Methylation of INSIGF was lower among individuals who were periconceptionally exposed to the famine (n = 60) compared with their unexposed same-sex siblings (P = 2 x 10(-5)), whereas methylation of IL10, LEP, ABCA1, GNASAS and MEG3 was higher (all P < 10(-3)). A significant interaction with sex was observed for INSIGF, LEP and GNASAS. Next, methylation of eight representative loci was compared between 62 individuals exposed late in gestation and their unexposed siblings. Methylation was different for GNASAS (P = 1.1 x 10(-7)) and, in men, LEP (P = 0.017). Our data indicate that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure.
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Cites
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Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
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“Manipulation of the maternal diet during pregnancy leads to a persistent shift in average DNA methylation levels of specific genes in offspring, resulting in permanent changes in coat color or tail shape (17,18).”
BackgroundThe Dutch Famine and Its Long-Term Consequences for Adult Health
Roseboom, T., de Rooij, S., & Painter, R. (2006) · Early Human Development · doi:10.1016/j.earlhumdev.2006.07.001 · Cited by 1,137
An integrated epigenetic and genetic approach to common human disease
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Early onset of coronary artery disease after prenatal exposure to the Dutch famine
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Cohort Profile: The Dutch Hunger Winter Families Study
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Self-citationHeijmans, B. T., Kremer, D., Tobi, E. W., Boomsma, D. I., & Slagboom, P. E. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm010 · Cited by 238 · cited 1×
“Data quality control and filtering were done as described previously (45).”
MethodSelf-citation
Cited by
Sex differences in immune responses
Klein, S. L., & Flanagan, K. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.90 · Cited by 6,370
Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus
Kautzky-Willer, A., Harreiter, J., & Pacini, G. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1137 · Cited by 2,043
Epigenetics and the environment: emerging patterns and implications
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Obesity Pathogenesis: An Endocrine Society Scientific Statement
Schwartz, M. W., Seeley, R. J., Zeltser, L. M., Drewnowski, A., Ravussin, E., Redman, L. M., & Leibel, R. L. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00111 · Cited by 727
DNA methylation signatures link prenatal famine exposure to growth and metabolism
Tobi, E. W., Goeman, J. J., Monajemi, R., Gu, H., Putter, H., Zhang, Y., Slieker, R. C., Stok, A. P., Thijssen, P. E., Müller, F., et al. (2014) · Nature Communications · doi:10.1038/ncomms6592 · Cited by 630
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Metadata
- Authors
- Tobi, E. W., Lumey, L. H., Talens, R. P., Kremer, D., Putter, H., Stein, A. D., Slagboom, P. E., & Heijmans, B. T.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-08-04
- Volume
- 18
- Issue
- 21
- Pages
- 4046-4053
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2167015768
- Cited by
- 1,155
- References
- 10
- FWCI
- 56.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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