The DOI matches its Crossref record.
Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: systematic review and meta-analysis
Abstract
BACKGROUND: Sperm DNA damage is common amongst infertile men and may adversely impact natural reproduction, IUI-assisted reproduction and to a lesser degree IVF pregnancy. The aim of this study was to examine the influence of sperm DNA damage on the risk of spontaneous pregnancy loss after IVF and ICSI. METHODS: We conducted a systematic review and meta-analysis of studies on sperm DNA damage and pregnancy loss after an IVF and/or ICSI pregnancy. RESULTS: Two by two tables were constructed and odds ratios (ORs) were derived from 11 estimates of pregnancy loss (five IVF and six ICSI studies from seven reports). These 11 studies involved 1549 cycles of treatment (808 IVF and 741 ICSI cycles) with 640 pregnancies (345 IVF and 295 ICSI) and 122 pregnancy losses. The combined OR of 2.48 (95% CI 1.52, 4.04, P < 0.0001) indicates that sperm DNA damage is predictive of pregnancy loss after IVF and ICSI. CONCLUSIONS: In conclusion, sperm DNA damage is associated with a significantly increased risk of pregnancy loss after IVF and ICSI. These data provide a clinical indication for the evaluation of sperm DNA damage prior to IVF or ICSI and a rationale for further investigating the association between sperm DNA damage and pregnancy loss.
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Citations
Cited by
The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis
Robinson, L., Gallos, I. D., Conner, S. J., Rajkhowa, M., Miller, D., Lewis, S., Kirkman-Brown, J., & Coomarasamy, A. (2012) · Human Reproduction · doi:10.1093/humrep/des261 · Cited by 629
Zhao, J., Zhang, Q., Wang, Y., & Li, Y. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.06.033 · Cited by 361
Parmegiani, L., Cognigni, G. E., Bernardi, S., Troilo, E., Ciampaglia, W., & Filicori, M. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.03.033 · Cited by 264
Oxidative DNA damage impairs global sperm DNA methylation in infertile men
Tunc, O., & Tremellen, K. (2009) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-009-9346-2 · Cited by 248
Antioxidants and sperm DNA damage: a clinical perspective
Zini, A., San Gabriel, M., & Baazeem, A. (2009) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-009-9343-5 · Cited by 203
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Metadata
- Authors
- Zini, A., Boman, J. M., Belzile, E., & Ciampi, A.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-09-01
- Volume
- 23
- Issue
- 12
- Pages
- 2663-2668
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2143396424
- Cited by
- 576
- References
- 0
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zini, A., Boman, J. M., Belzile, E., & Ciampi, A. (2008). Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: systematic review and meta-analysis. Human Reproduction. https://doi.org/10.1093/humrep/den321
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