Poor sleep in PCOS; is melatonin the culprit?
Abstract
Study question Are daily cycles in urinary melatonin and oxidative stress marker levels (8-hydroxydeoxyguanosine) altered in PCOS, and is this associated with changes in sleep quality? Summary answer There is an association between elevated nighttime melatonin and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, and poor sleep quality in our PCOS study group. What is known already Women with PCOS are known to have poorer sleep. However, there have been few studies examining the possible association between melatonin levels and sleep quality in women with polycystic ovarian syndrome (PCOS). Study design, size, duration This is a case-control study of PCOS (n = 26) and non-PCOS control (n = 26) subjects recruited from a tertiary gynaecological centre. Participants/materials, setting, methods The participants were requested to complete sleep questionnaires for a month. In a subgroup from these cohorts (PCOS, n = 15; controls, n = 18), urine samples were also collected at various time points over a 24-h period. In addition, their sleep patterns and lighting environment were monitored for 3 consecutive days and nights using a wrist-mounted Actiwatch device. Main results and the role of chance PCOS women had significantly elevated night-time urinary levels of the melatonin metabolite 6-sulfatoxymelatonin (aMT6s) and of 8-OHdG (both at P Limitations, reasons for caution Due to the small sample size of the study, further studies will be required to confirm our findings. Wider implications…
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Ten studies included information regarding the use of wearables.
“Ten studies included information regarding the use of wearables [77,78,79,80,81,82,83,84,85,86] (Supplementary File S3).”
From Polycystic Ovary Syndrome and the Internet of Things: A Scoping Review (2024) · cites this paper as [80]
Sleep efficiency was significantly lower for those with PCOS (Actiwatch data: 82.8 ± 4.7 vs. 85.6 ± 4.3).
“and sleep efficiency was significantly lower for those with PCOS (Actiwatch data: 82.8 ± 4.7 vs. 85.6 ± 4.3) [80].”
From Polycystic Ovary Syndrome and the Internet of Things: A Scoping Review (2024) · cites this paper as [80]
Wearables used included activity trackers, sleep monitors, 24-h blood pressure monitors, and more invasive ones inserted into the abdominal interstitial tissue for continuous glucose monitoring.
“Wearables used included activity trackers [78,79,82], sleep monitors [77,80], 24-h blood pressure monitors [83], and more invasive ones inserted into the abdominal interstitial tissue for continuous glucose monitoring [81,84,85,86].”
From Polycystic Ovary Syndrome and the Internet of Things: A Scoping Review (2024) · cites this paper as [80]
The use of wearables such as activity and sleep trackers, as well as mobile apps for symptom tracking, can keep clinicians informed about patients' progress, consequently promoting communication and engagement.
“The use of wearables such as activity [78,79] and sleep trackers [77,80], as well as mobile apps for symptom tracking [53,54], can keep clinicians informed about patients’ progress, consequently promoting communication and engagement.”
From Polycystic Ovary Syndrome and the Internet of Things: A Scoping Review (2024) · cites this paper as [80]
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Fernandez, R., Moore, V., Van Ryswyk, E., Varcoe, T., Rodgers, R., March, W., Moran, L., Avery, J., McEvoy, D., & Davies, M. (2018) · Nature and Science of Sleep · doi:10.2147/nss.s127475 · Cited by 137 · see citing works
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Wang, C., Huang, T., Song, W., Zhu, J., Liu, Y., Chen, X., Sun, X., Wu, Q., Chen, H., Liao, H., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.957112 · Cited by 19 · see citing works
Polycystic Ovary Syndrome and the Internet of Things: A Scoping Review
Graca, S., Alloh, F., Lagojda, L., Dallaway, A., Kyrou, I., Randeva, H. S., & Kite, C. (2024) · Healthcare · doi:10.3390/healthcare12161671 · Cited by 14 · see citing works
Beyond counting sheep: Exploring the link between polycystic ovary syndrome and sleep health
Jafar, N. K. A., Bennett, C. J., Moran, L. J., & Mansfield, D. R. (2023) · Seminars in Reproductive Medicine · doi:10.1055/s-0043-1777724 · Cited by 12 · see citing works
- Authors
- Shreeve, N., Cagampang, F., Sadek, K., Tolhurst, M., Houldey, A., Hill, C. M., Brook, N., Macklon, N., & Cheong, Y.
- Affiliations
- Princess Anne Hospital (GB)
- University of Southampton (GB)
- Corresponding author
- Shreeve, N.
- Cagampang, F.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-02-24
- Volume
- 28
- Issue
- 5
- Pages
- 1348-1353
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2123705171
- Cited by
- 73
- References
- 0
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 12 · 2021: 9 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 2
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- polycystic ovary syndrome, sleep quality, melatonin, urinary 6-sulfatoxymelatonin, oxidative stress, 8-hydroxy-2'-deoxyguanosine
- MeSH terms
- 8-Hydroxy-2'-Deoxyguanosine, Adolescent, Adult, Deoxyguanosine, Female, Hormones, Humans, Melatonin, Monitoring, Physiologic, Polycystic Ovary Syndrome, Surveys and Questionnaires, Sleep, Sleep Wake Disorders, Case-Control Studies, Oxidative Stress, Young Adult
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