The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Sperm transport in the female reproductive tract
Open accessAbstract
At coitus, human sperm are deposited into the anterior vagina, where, to avoid vaginal acid and immune responses, they quickly contact cervical mucus and enter the cervix. Cervical mucus filters out sperm with poor morphology and motility and as such only a minority of ejaculated sperm actually enter the cervix. In the uterus, muscular contractions may enhance passage of sperm through the uterine cavity. A few thousand sperm swim through the uterotubal junctions to reach the Fallopian tubes (uterine tubes, oviducts) where sperm are stored in a reservoir, or at least maintained in a fertile state, by interacting with endosalpingeal (oviductal) epithelium. As the time of ovulation approaches, sperm become capacitated and hyperactivated, which enables them to proceed towards the tubal ampulla. Sperm may be guided to the oocyte by a combination of thermotaxis and chemotaxis. Motility hyperactivation assists sperm in penetrating mucus in the tubes and the cumulus oophorus and zona pellucida of the oocyte, so that they may finally fuse with the oocyte plasma membrane. Knowledge of the biology of sperm transport can inspire improvements in artificial insemination, IVF, the diagnosis of infertility and the development of contraceptives.
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Cites
Kunz, G., Beil, D., Deininger, H., Wildt, L., & Leyendecker, G. (1996) · Human Reproduction · doi:10.1093/humrep/11.3.627 · Cited by 408 · cited 2×
“As described above, motile human sperm have been recovered from Fallopian tubes within an hour of insemination; however, it is not known whether function was normal in these women (Rubenstein et al., 1951).”
BackgroundLyons, E. A., Taylor, P. J., Zheng, X. H., Ballard, G., Levi, C. S., & Kredentser, J. V. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54246-0 · Cited by 272 · cited 3×
“The uterine contractions occurring in women during the periovulatory period are limited to the layer of myometrium directly beneath the endometrium (Lyons et al., 1991; de Ziegler et al., 2001).”
BackgroundPhysiology: Sperm numbers and distribution within the human Fallopian tube around ovulation
Williams, M., Hill, C. J., Scudamore, I., Dunphy, B., Cooke, I. D., & Barratt, C. L. R. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137975 · Cited by 148
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Berke, A. P., Turner, L., Berg, H. C., & Lauga, E. (2008) · Physical Review Letters · doi:10.1103/physrevlett.101.038102 · Cited by 873
Acid Extrusion from Human Spermatozoa Is Mediated by Flagellar Voltage-Gated Proton Channel
Lishko, P. V., Botchkina, I. L., Fedorenko, A., & Kirichok, Y. (2010) · Cell · doi:10.1016/j.cell.2009.12.053 · Cited by 386
Friedrich, B. M., & Jülicher, F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703530104 · Cited by 287
Sugar‐coated sperm: Unraveling the functions of the mammalian sperm glycocalyx
Tecle, E., & Gagneux, P. (2015) · Molecular Reproduction and Development · doi:10.1002/mrd.22500 · Cited by 190
Modifiable and non-modifiable risk factors for poor sperm morphology
Pacey, A. A., Povey, A. C., Clyma, J. A., McNamee, R., Moore, H. D., Baillie, H., Cherry, N. M., & Chaps-UK, P. C. O. (2014) · Human Reproduction · doi:10.1093/humrep/deu116 · Cited by 107
Self-citation
Metadata
- Authors
- Suarez, S. S., & Pacey, A. A.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-11-04
- Volume
- 12
- Issue
- 1
- Pages
- 23-37
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2153344238
- Cited by
- 1,113
- References
- 3
- FWCI
- 20.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
