The DOI matches its Crossref record; 177 of the 177 references it cites were found in a registry or an index.
Paternal age and reproduction
Abstract
BACKGROUND: Due to various sociological factors, couples in developed countries are increasingly delaying childbearing. Besides ethical, economical and sociological issues, this trend presents us with several complex problems in reproduction. Although it is well-known that maternal age has a negative effect on fertility and increases the risk of adverse outcome during pregnancy and in offspring, the paternal influence on these outcomes is less well researched and not well-known. METHODS: We performed a systematic search of PubMed, and retrieved original articles and review articles to update our previous survey in this journal. RESULTS: This review highlights the link between male age and genetic abnormalities in the germ line and summarizes the knowledge about the effects of paternal age on reproductive function and outcome. Increasing paternal age can be associated with decreasing androgen levels, decreased sexual activity, alterations of testicular morphology and a deterioration of semen quality (volume, motility, morphology). Increased paternal age has an influence on DNA integrity of sperm, increases telomere length in spermatozoa and is suggested to have epigenetic effects. These changes may, at least in part, be responsible for the association of paternal age over 40 years with reduced fertility, an increase in pregnancy-associated complications and adverse outcome in the offspring. CONCLUSION: Although higher maternal age can be an indication for intensive prenatal diagnosis, including invasive diagnostics, consideration of the available evidence suggests that paternal age itself, however, provides no rationale for invasive procedures.
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Cites
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Cited by
Demographic and medical consequences of the postponement of parenthood
Schmidt, L., Sobotka, T., Bentzen, J. G., Nyboe Andersen, A., & on behalf of the ESHRE Reproduction and Society Task Force (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr040 · Cited by 656
The physiology of endocrine systems with ageing
van den Beld, A. W., Kaufman, J.-M., Zillikens, M. C., Lamberts, S. W. J., Egan, J. M., & van der Lely, A. J. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30026-3 · Cited by 349
du Fossé, N. A., van der Hoorn, M.-L. P., van Lith, J. M. M., le Cessie, S., & Lashley, E. E. L. O. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa010 · Cited by 276
Delayed childbearing: effects on fertility and the outcome of pregnancy
Balasch, J., & Gratacós, E. (2012) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e3283517908 · Cited by 253
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Metadata
- Authors
- Sartorius, G. A., & Nieschlag, E.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-08-20
- Volume
- 16
- Issue
- 1
- Pages
- 65-79
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2144779297
- Cited by
- 355
- References
- 177
- FWCI
- 21.89
- Type
- journal article
- Language
- en
- Open access
- closed
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