Cited by 175Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Function and Risk Factors

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Carotid artery intima-media thickness in polycystic ovary syndrome: a systematic review and meta-analysis

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Meyer, Michelle L., Malek, Angela M., Wild, Robert A., Korytkowski, Mary T., Talbott, Evelyn O.·2012·Human Reproduction Update

DOI 10.1093/humupd/dmr046PMC PMC3383099

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Abstract

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder associated with cardiovascular disease (CVD) risk factors and metabolic disturbances. This systematic review and meta-analysis was conducted to determine whether carotid intima-media thickness (CIMT), a marker of subclinical atherosclerosis, is higher in women with PCOS compared with women without PCOS. METHODS: Primary articles reporting the mean CIMT in women with PCOS and controls were identified using Ovid MEDLINE, EMBASE and PUBMED. We performed a random-effects meta-analysis and created forest plots of the mean difference in CIMT and conducted tests for heterogeneity and publication bias. Studies were grouped by quality, defined by reporting reproducibility of CIMT and averaging both common carotid arteries versus one side for CIMT. RESULTS: From the 36 eligible full-text studies, 8 studies were included in the systematic review and 19 studies were included in the meta-analysis (total n= 1123 women with PCOS, n= 923 controls). The summary mean difference in CIMT among women with PCOS compared with controls was 0.072 mm [95% confidence interval (CI) 0.040, 0.105, P < 0.0001] for highest quality studies, 0.084 mm (95% CI 0.042, 0.126, P = 0.0001) for good quality studies, 0.041 (95% CI -0.038, 0.120, P = 0.310) for fair-quality studies and 0.045 (95% CI -0.020, 0.111, P = 0.173) for lower quality studies. CONCLUSIONS: Larger studies with a well-defined PCOS population using rigorous methodology may be required to draw a more robust conclusion. However, these results suggest women with PCOS are at a greater risk of premature atherosclerosis, which emphasizes the importance of screening and monitoring CVD risk factors in women with PCOS.

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Moore, M. E., Hirani, R., Khessib, S., Chirumamilla, A. P., Frishman, W. H., & Etienne, M. (2026) · Cardiology in Review · doi:10.1097/crd.0000000000001453
Effect of fish oil as an adjunct therapy to metformin on vascular and cardiac health in women with polyendocrine metabolic ovarian syndrome: protocol for a randomised, placebo-controlled clinical trial
Sydora, B. C., Ghosh, M., Chambers, S., Haase, A., Davenport, M. H., Beaulieu, C., Thompson, R. B., Windram, J., Becher, H., Raggi, P., et al. (2026) · BMJ Open · doi:10.1136/bmjopen-2026-124025
“32 78–80 In addition, they display impaired endothelial function, hypertension and cardiac remodelling-dysfunction including left ventricular (LV) hypertrophy and LV global longitudinal strain (GLS).”
The organelle oxidative-inflammatory network in polycystic ovary syndrome: from subcellular intercellular cascades to systemic comorbidities
Ou, K., Zhang, D., Liao, Y., Yu, T., 刘文兴, Sun, T., & Huang, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1922372
“Notably, PCOS predicts increased carotid intima-media thickness (CIMT) more strongly than traditional risk factors including age and body mass index (196).”
Phenotype-specific cardiometabolic risk in PMOS (formerly PCOS): an ovarian-endocrine perspective on reproductive and long-term health
Kawuribi, V., Adu‐Amankwaah, J., & Yalley, S. K. (2026) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2026.106034

Authors: Meyer, M. L., Malek, A. M., Wild, R. A., Korytkowski, M. T., & Talbott, E. O.
Affiliations: University of North Carolina at Chapel Hill (US)
University of Pittsburgh (US)
OU Health (US)
University of Pittsburgh Medical Center (US)
Corresponding author: Meyer, Michelle L.
ORCID: Meyer, Michelle L.
Malek, Angela M.
Wild, Robert A.
Korytkowski, Mary T.
Talbott, Evelyn O.
Venue: Human Reproduction Update
Publisher: Oxford University Press (OUP)
Published: 2011-11-22
Volume: 18
Issue: 2
Pages: 112-126
ISSN: 1355-4786 (ISSN-L)
1460-2369
DOI: 10.1093/humupd/dmr046
PMC: PMC3383099
OpenAlex: W2165694459
Cited by: 175
References: 79
Citations by year: 2026: 12 · 2025: 9 · 2024: 12 · 2023: 10 · 2022: 10 · 2021: 17 · 2020: 12 · 2019: 18 · 2018: 12 · 2017: 9 · 2016: 7 · 2015: 22 · 2014: 16 · 2013: 7 · 2012: 1
FWCI: 1.24
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Human Reproduction Update (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (T32 5T32HL007055-35, T32HL083825, T32HL007055)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: polycystic ovary syndrome, carotid intima-media thickness, subclinical atherosclerosis, cardiovascular risk, premature atherosclerosis, women's cardiovascular health, study quality heterogeneity
MeSH terms: Female, Humans, Polycystic Ovary Syndrome, Risk Factors, Atherosclerosis, Carotid Intima-Media Thickness

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Carotid artery intima-media thickness in polycystic ovary syndrome: a systematic review and meta-analysis

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