Cited by 503Inflammatory Bowel DiseaseHealth Systems, Economic Evaluations, Quality of LifeOcular Diseases and Behçet’s Syndrome

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Quality of Life in Inflammatory Bowel Disease: A Systematic Review and Meta-analyses—Part I

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Knowles, Simon R, Graff, Lesley A, Wilding, Helen, Hewitt, Catherine, Keefer, Laurie, Mikocka-Walus, Antonina·2018·Inflammatory Bowel Diseases

DOI 10.1093/ibd/izx100

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Abstract

Background: Quality of life (QoL) is commonly assessed in inflammatory bowel disease (IBD); the relationship of QoL within IBD states and relative to others has not been comprehensively evaluated. This systematic review, published across 2 papers, evaluates 5 key QoL comparisons. Part I, presented here, examines between-disease comparisons: (1) IBD/healthy(general) population and (2) IBD/other medically ill groups. Part II examines within-disease comparisons: (3) active/inactive disease, (4) ulcerative colitis/Crohn's disease, and (5) change over time. Outcomes using generic vs IBD-specific QoL measures were also examined. Methods: Adult and pediatric studies were identified through systematic searches of 7 databases from the 1940s (where available) to October 2015. Results: Of 6173 abstracts identified, 466 were selected for final review based on controlled design and validated measurement; 30 unique studies (23 adult, 7 pediatric) addressed the between-disease comparisons. The pooled mean QoL scores were (1) lower in adult and pediatric IBD samples compared with healthy controls (n = 19), and for both mental and physical QoL, where measured; and (2) higher but not significant for those with IBD compared with various medically ill controls (n = 15). Findings were consistent across IBD-specific and generic QoL measures. Study quality was generally low to moderate. The most common measures of QoL were the disease-specific Inflammatory Bowel Disease Questionnaire and generic SF-36 (adults), and the generic PedsQL (children). Conclusions: There was robust confirmation that QoL for individuals with IBD was poorer than for healthy individuals, for both adults and children. QoL in IBD may be better relative to some other gastrointestinal (GI) and non-GI medical conditions for children.

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Authors: Knowles, S. R., Graff, L. A., Wilding, H., Hewitt, C., Keefer, L., & Mikocka-Walus, A.
Affiliations: The Royal Melbourne Hospital (AU)
University of Manitoba (CA)
The University of Melbourne (AU)
University of York (GB)
Icahn School of Medicine at Mount Sinai (US)
Department of Health Sciences, University of York, York, United Kingdom
Corresponding author: Knowles, Simon R
ORCID: Knowles, Simon R
Graff, Lesley A
Wilding, Helen
Hewitt, Catherine
Keefer, Laurie
Venue: Inflammatory Bowel Diseases
Publisher: Oxford University Press (OUP)
Published: 2018-03-19
Volume: 24
Issue: 4
Pages: 742-751
ISSN: 1078-0998 (ISSN-L)
1536-4844
DOI: 10.1093/ibd/izx100
OpenAlex: W4235023600
Cited by: 503
References: 54
Citations by year: 2026: 57 · 2025: 76 · 2024: 99 · 2023: 91 · 2022: 63 · 2021: 59 · 2020: 30 · 2019: 23 · 2018: 5
FWCI: 4.03
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/journals/pages/about_us/legal/notices (vor)
Locations: Inflammatory Bowel Diseases (publishedVersion)
PubMed (publishedVersion)
Own your potential (DEAKIN) (submittedVersion)
Figshare (submittedVersion, cc-by)
Swinburne figshare (Swinburne University of Technology) (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: quality of life, inflammatory bowel disease
MeSH terms: Adaptation, Psychological, Anxiety, Depression, Humans, Quality of Life, Severity of Illness Index, Inflammatory Bowel Diseases, Risk Assessment

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Quality of Life in Inflammatory Bowel Disease: A Systematic Review and Meta-analyses—Part I

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