Age Modifies the Association Between Depressive Symptoms and Adherence to Self-Testing With Telemedicine in Patients With Inflammatory Bowel Disease
Open accessAbstract
Background: Depression is common in patients with inflammatory bowel disease (IBD) and is known to be associated with poor adherence in the usual care setting. In the last decade, there has been an increase in the use of information technology (IT) for the delivery of IBD care, but the association between depressive symptoms (DS) and adherence to self-testing in this context is not known. We aimed to investigate this association among IBD patients managed via a text messaging-based telemedicine system. Methods: This was a prospective study of participants in the 2 intervention arms of the Telemedicine for Patients with IBD (TELE-IBD) trial. Depressive symptoms were measured at baseline, and then participants received periodic text messages to initiate IBD-specific self-testing. Treatment plans were similarly conveyed, and adherence to self-testing was evaluated at the end of 1 year. Regression analyses were performed, and age-stratified models were constructed to evaluate for effect modification. Results: Of the 193 study participants, 48% had DS at baseline. Overall, there was no significant association between DS and adherence to self-testing. However, upon stratification by age, adherence increased with depressive symptoms in those that were 40 years and younger (P = 0.02), but there was no association between depressive symptoms and adherence in the older group (P = 0.53). Conclusions: Younger IBD patients with DS have high adherence when managed in a text messaging-based telemedicine program. Telemedicine interventions have the potential to improve health outcomes in this demographic-a group that is often thought to be difficult to manage due to nonadherence.
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Chudy-Onwugaje et al found that age has an interacting effect with people's depression symptoms.
“Chudy-Onwugaje et al [73] found that age has an interacting effect with people’s depression symptoms.”
From Barriers to and facilitators of user engagement with digital mental health interventions: Systematic review (2021) · cites this paper as [73]
The Results report a significant interaction between age and depressive symptoms in predicting adherence to self-testing among patients with inflammatory bowel disease. The claim omits that outcome and population, making the finding sound like a general interaction between age and depressive symptoms themselves. (LLM, conf=0.84)
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References 36 · Cited by 13
- Authors
- Chudy-Onwugaje, K., Abutaleb, A., Buchwald, A., Langenberg, P., Regueiro, M., Schwartz, D. A., Tracy, J. K., Ghazi, L., Patil, S. A., Quezada, S., Russman, K., Horst, S., Beaulieu, D., Quinn, C., Jambaulikar, G., & Cross, R. K.
- Affiliations
- Division of Gastroenterology and Hepatology, Department of Medicine
- University of Maryland, Baltimore (US)
- University of Pittsburgh (US)
- Vanderbilt University (US)
- Dartmouth–Hitchcock Medical Center (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Cross, Raymond K
- ORCID
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-05-28
- Volume
- 24
- Issue
- 12
- Pages
- 2648-2654
- ISSN
- 1078-0998 (ISSN-L)
- 1536-4844
- PMC
- PMC6262196
- OpenAlex
- W2807093383
- Cited by
- 13
- References
- 36
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 3
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Inflammatory Bowel Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Litwin Pioneers Program at the Crohn’s and Colitis Foundation (431257)
- Agency for Healthcare Research and Quality (1R01HS018975-01A1, DK067872-11)
- National Institutes of Health
- Topics
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Telemedicine and Telehealth Implementation
- Keywords
- inflammatory bowel disease, depressive symptoms
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Depression, Female, Humans, Male, Middle Aged, Patient Compliance, Prospective Studies, Quality of Life, Self Care, United States, Inflammatory Bowel Diseases, Logistic Models, Telemedicine, Young Adult, Text Messaging
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