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Psychiatric History and Related Exposures as Risk Factors for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies
Open accessAbstract
Data from case-control studies of Alzheimer's disease (AD) were pooled to examine the possible roles of history of depression, anti-depressant treatment and adverse life events as risk factors. History of depression was found to be associated with AD, although the effect was confined to late onset cases. The association held for episodes of depression more than 10 years before AD onset, as well as for episodes occurring within a decade of onset. No association was found with anti-depressant treatment. However, data were only available from two studies, limiting the power of the analysis. Also, no association was found with the three major life events considered in the pooled analysis: death of spouse, death of a child and divorce.
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Cited by
Ownby, R. L., Crocco, E., Acevedo, A., John, V., & Loewenstein, D. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.5.530 · Cited by 1,493
The Nature and Determinants of Neuropsychological Functioning in Late-LifeDepression
Butters, M. A., Whyte, E. M., Nebes, R. D., Begley, A. E., Dew, M. A., Mulsant, B. H., Zmuda, M. D., Bhalla, R., Meltzer, C. C., Pollock, B. G., et al. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.6.587 · Cited by 622
Depression as a Risk Factor for Alzheimer Disease: The MIRAGE Study
Green, R. C., Cupples, L. A., Kurz, A., Auerbach, S., Go, R., Sadovnick, D., Duara, R., Kukull, W. A., Chui, H., Edeki, T., et al. (2003) · Archives of Neurology · doi:10.1001/archneur.60.5.753 · Cited by 551
Depressed Mood and the Incidence of Alzheimer's Disease in the Elderly Living in the Community
Devanand, D. P. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830020093011 · Cited by 549
Depressive symptoms, cognitive decline, and risk of AD in older persons
Wilson, R. S., Barnes, L. L., Mendes de Leon, C. F., Aggarwal, N. T., Schneider, J. S., Bach, J., Pilat, J., Beckett, L. A., Arnold, S. E., Evans, D. A., et al. (2002) · Neurology · doi:10.1212/wnl.59.3.364 · Cited by 528
Metadata
- Authors
- Jorm, A. F., Van Duijn, C. M., Chandra, V, Fratiglioni, L., Graves, A. B., Heyman, A., Kokmen, E., Kondo, K., Mortimer, J. A., Rocca, W. A., Shalat, S. L., Soininen, H., & A Hofman for the Eurodem Risk Factors Research Group
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-01-01
- Volume
- 20
- Issue
- Supplement 2
- Pages
- S43-S47
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- OpenAlex
- W2100306414
- Cited by
- 237
- References
- 0
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Psychiatric History and Related Exposures as Risk Factors for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies. https://app.cochat.ai/papers/10.1093/ije/20.supplement_2.s43
- The paper
- Jorm, A. F., Van Duijn, C. M., Chandra, V, Fratiglioni, L., Graves, A. B., Heyman, A., Kokmen, E., Kondo, K., Mortimer, J. A., Rocca, W. A., Shalat, S. L., Soininen, H., & A Hofman for the Eurodem Risk Factors Research Group. (1991). Psychiatric History and Related Exposures as Risk Factors for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies. International Journal of Epidemiology. https://doi.org/10.1093/ije/20.supplement_2.s43
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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