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Serum Total Homocysteine and Coronary Heart Disease
Abstract
BACKGROUND: Several studies have observed high plasma levels of homocysteine among patients with coronary heart disease (CHD). The only prospective study was based on US physicians, and concluded that homocysteine was associated with subsequent myocardial infarction (MI). However, the association was limited to those above a threshold level of homocysteine. METHODS: We conducted a nested case-control study among the 21,826 subjects, aged 12-61 years, who were surveyed in the municipality of Tromsø, Norway. Among those free from MI at the screening, 123 later developed CHD. Four controls were selected for each case. RESULTS: Level of homocysteine was higher in cases than in controls (12.7 +/- 4.7 versus 11.3 +/- 3.7 mumol/l (mean +/- SD); P = 0.002). The relative risk for a 4 mumol/l increase in serum homocysteine was 1.41 (95% confidence interval (CI): 1.16-1.71). Adjusting for possible confounders reduced the relative risk to 1.32 (95% CI: 1.05-1.65). There was no threshold level above which serum homocysteine is associated with CHD events. CONCLUSIONS: In the general population serum total homocysteine is an independent risk factor for CHD with no threshold level.
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Cited by
Homocysteine and Cardiovascular Disease
Refsum, H., Ueland, P. M., Nygård, O., & Vollset, S. E. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.31 · Cited by 2,180
Self-citationHomocysteine and Risk of Ischemic Heart Disease and Stroke: A Meta-analysis
Homocysteine Studies Collaboration (2002) · JAMA · doi:10.1001/jama.288.16.2015 · Cited by 2,059
Homocysteine and Atherothrombosis
Welch, G. N., & Loscalzo, J. (1998) · New England Journal of Medicine · doi:10.1056/nejm199804093381507 · Cited by 1,997
Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease
Nygård, O., Nordrehaug, J. E., Refsum, H., Ueland, P. M., Farstad, M., & Vollset, S. E. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707243370403 · Cited by 1,756
Self-citationPlasma Homocysteine as a Risk Factor for Vascular Disease: The European Concerted Action Project
Graham, I. M. (1997) · JAMA · doi:10.1001/jama.1997.03540460039030 · Cited by 1,738
Metadata
- Authors
- ARNESEN, E., REFSUM, H., BØNAA, K. H., UELAND, P. M., FØRDE, O. H., & NORDREHAUG, J. E.
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1995
- Volume
- 24
- Issue
- 4
- Pages
- 704-709
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- OpenAlex
- W2058737278
- Cited by
- 651
- References
- 0
- FWCI
- 33.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- ARNESEN, E., REFSUM, H., BØNAA, K. H., UELAND, P. M., FØRDE, O. H., & NORDREHAUG, J. E. (1995). Serum Total Homocysteine and Coronary Heart Disease. International Journal of Epidemiology. https://doi.org/10.1093/ije/24.4.704
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