The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDS
Open accessAbstract
BACKGROUND: In the era of highly active antiretroviral therapy (HAART) mortality has decreased substantially among human immunodeficiency virus (HIV)-infected people with access to HAART, but there are concerns regarding co-morbidities and adverse effects of HAART, which may impair vital prognosis. The Mortality 2000 study examined the causes of death in HIV-infected adults at a national level in France in the year 2000. METHODS: All French hospital wards known to be involved in the management of HIV infection were asked to notify prospectively the deaths that occurred in 2000 among HIV-infected adults. The causes of death were documented using a standardized questionnaire. RESULTS: The 185 participating wards notified 964 deaths. The main underlying causes of death were AIDS-related (47%, non-Hodgkin's lymphoma: 23%), viral hepatitis (11%, hepatitis C: 9%, hepatitis B: 2%), cancer not related to AIDS or hepatitis (11%), cardiovascular disease (7%), bacterial infections (6%), suicide (4%), and adverse effect of antiretroviral treatments (1%). Among AIDS-related deaths, HIV infection had been diagnosed recently in 20%. Smoking was recorded in 72% of cancer-related deaths and alcohol consumption in 54% of hepatitis-related deaths. Among non-HIV related deaths between 25 and 64 years, the proportion of infectious diseases (including HCV and HBV-related deaths) was higher in HIV-infected adults than in the general population. CONCLUSIONS: Improved strategies for detecting HIV infection before AIDS-defining complications occur are needed in the era of HAART. The prevention of non-AIDS related cancers, especially lung cancer, the management of non-Hodgkin's lymphoma, and of viral hepatitis are also important priorities.
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Cited by
Andrade, R. J., Chalasani, N., Björnsson, E. S., Suzuki, A., Kullak-Ublick, G. A., Watkins, P. B., Devarbhavi, H., Merz, M., Lucena, M. I., Kaplowitz, N., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0105-0 · Cited by 924
(2010) · Clinical Infectious Diseases · doi:10.1086/652283 · Cited by 594
Sackoff, J. E., Hanna, D. B., Pfeiffer, M. R., & Torian, L. V. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-6-200609190-00003 · Cited by 451
Lewden, C., May, T., Rosenthal, E., Burty, C., Bonnet, F., Costagliola, D., Jougla, E., Semaille, C., Morlat, P., Salmon, D., et al. (2008) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31817efb54 · Cited by 342
Self-citation
Metadata
- Authors
- Lewden, C.
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-08-27
- Volume
- 34
- Issue
- 1
- Pages
- 121-130
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- OpenAlex
- W2169085525
- Cited by
- 373
- References
- 28
- FWCI
- 16.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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