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Cited by 552

The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.

Assessment of cumulative evidence on genetic associations: interim guidelines

Open access
Ioannidis, J. P., Boffetta, P., Little, J., O'Brien, T. R, Uitterlinden, A. G, Vineis, P., Balding, D. J, Chokkalingam, A., Dolan, S. M, Flanders, W D., Higgins, J. P., McCarthy, M. I, McDermott, D. H, Page, G. P, Rebbeck, T. R, Seminara, D., Khoury, M. J·2008·International Journal of Epidemiology

Abstract

Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing cumulative epidemiologic evidence in genetic associations. A proposed semi-quantitative index assigns three levels for the amount of evidence, extent of replication, and protection from bias, and also generates a composite assessment of 'strong', 'moderate' or 'weak' epidemiological credibility. In addition, we discuss how additional input and guidance can be derived from biological data. Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors.

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Metadata

Authors
Ioannidis, J. P., Boffetta, P., Little, J., O'Brien, T. R., Uitterlinden, A. G., Vineis, P., Balding, D. J., Chokkalingam, A., Dolan, S. M., Flanders, W. D., Higgins, J. P., McCarthy, M. I., McDermott, D. H., Page, G. P., Rebbeck, T. R., Seminara, D., & Khoury, M. J.
Venue
International Journal of Epidemiology
Published
2007-09-26
Volume
37
Issue
1
Pages
120-132
ISSN
  • 0300-5771 (ISSN-L)
  • 1464-3685
OpenAlex
W2128201302
Cited by
552
References
88
FWCI
20.26
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Assessment of cumulative evidence on genetic associations: interim guidelines. https://app.cochat.ai/papers/10.1093/ije/dym159
The paper
Ioannidis, J. P., Boffetta, P., Little, J., O'Brien, T. R., Uitterlinden, A. G., Vineis, P., Balding, D. J., Chokkalingam, A., Dolan, S. M., Flanders, W. D., Higgins, J. P., McCarthy, M. I., McDermott, D. H., Page, G. P., Rebbeck, T. R., Seminara, D., & Khoury, M. J. (2008). Assessment of cumulative evidence on genetic associations: interim guidelines. International Journal of Epidemiology. https://doi.org/10.1093/ije/dym159

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.