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Robust causal inference using directed acyclic graphs: the R package ‘dagitty’
Open accessAbstract
Directed acyclic graphs (DAGs), which offer systematic representations of causal relationships, have become an established framework for the analysis of causal inference in epidemiology, often being used to determine covariate adjustment sets for minimizing confounding bias. DAGitty is a popular web application for drawing and analysing DAGs. Here we introduce the R package 'dagitty', which provides access to all of the capabilities of the DAGitty web application within the R platform for statistical computing, and also offers several new functions. We describe how the R package 'dagitty' can be used to: evaluate whether a DAG is consistent with the dataset it is intended to represent; enumerate 'statistically equivalent' but causally different DAGs; and identify exposure-outcome adjustment sets that are valid for causally different but statistically equivalent DAGs. This functionality enables epidemiologists to detect causal misspecifications in DAGs and make robust inferences that remain valid for a range of different DAGs. The R package 'dagitty' is available through the comprehensive R archive network (CRAN) at [https://cran.r-project.org/web/packages/dagitty/]. The source code is available on github at [https://github.com/jtextor/dagitty]. The web application 'DAGitty' is free software, licensed under the GNU general public licence (GPL) version 2 and is available at [http://dagitty.net/].
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“We then constructed a directed acyclic graph (DAG) to clearly define our a priori assumptions regarding covariate relationships with the exposure and outcome variables (Figure 1).29,30”
From Receipt of Glucagon-Like Peptide-1 Receptor Agonists Among Rural Patients with Obstructive Sleep Apnea and Excess Weight (2026) · cites this paper as [30]
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Cites
Causality: Models, Reasoning, and Inference
Pearl, J. (2009) · doi:10.1017/cbo9780511803161 · Cited by 11,653
Air Pollution and Hospital Admissions for Heart Disease in Eight U.S. Counties
Schwartz, J. D. (1999) · Epidemiology · doi:10.1097/00001648-199901000-00005 · Cited by 3,045
Reducing bias through directed acyclic graphs
Shrier, I., & Platt, R. W. (2008) · BMC Medical Research Methodology · doi:10.1186/1471-2288-8-70 · Cited by 1,442
Causal Inference in Statistics
Pearl, J., Glymour, M., & Jewell, N. P. (2016) · Cited by 1,436
Textor, J. C., Hardt, J., & Knüppel, S. (2011) · Epidemiology · doi:10.1097/ede.0b013e318225c2be · Cited by 1,227
Self-citationShipley, B. (2000) · Cited by 1,085
Kernel-based Conditional Independence Test and Application in Causal DiscoveryPreprint
Zhang, K., Peters, J., Janzing, D., & Schölkopf, B. (2012) · arXiv (Cornell University) · doi:10.48550/arxiv.1202.3775 · Cited by 373
On the Validity of Covariate Adjustment for Estimating Causal EffectsPreprint
Shpitser, I., VanderWeele, T. J., & Robins, J. M. (2012) · arXiv (Cornell University) · doi:10.48550/arxiv.1203.3515 · Cited by 124
J�nger, M., & Thienel, S. (2000) · Software Practice and Experience · doi:10.1002/1097-024x(200009)30:11 · Cited by 86
Greenland, S., & Mansournia, M. A. (2015) · European Journal of Epidemiology · doi:10.1007/s10654-015-9995-7 · Cited by 86
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Research works printed but not linked: 1
- Rothman KJ Greenland S Lash TL . Modern Epidemiology. Philadeplphia, PA: Lippincott Williams & Wilkins, 2008.
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Haddad, R., Turmel, N., Lagnau, P., Chesnel, C., Breton, F. L., Amarenco, G., & Hentzen, C. (2021) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2021.101539 · Cited by 12
Barnard‐Mayers, R., Childs, E., Corlin, L., Caniglia, E. C., Fox, M. P., Donnelly, J. P., & Murray, E. J. (2021) · European Journal of Epidemiology · doi:10.1007/s10654-021-00771-3 · Cited by 13
“Additionally, the authors of the literature review reported that extraction errors were reduced when diagrams were constructed using DAGitty, a web‐based platform for designing and exploring causal diagrams [14].”
MethodRoche, S., Bandyopadhyay, S., Grassam-Rowe, A., Brown, R., Iveson, P., Mallett, G., Eggington, H. R., & Swales, C. E. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-050104 · Cited by 12
Abbas, H., Aida, J., Kondo, K., & Osaka, K. (2022) · Journal of Prosthetic Dentistry · doi:10.1016/j.prosdent.2022.02.014 · Cited by 12
Papworth, A., Hackett, J., Beresford, B., Murtagh, F. E., Weatherly, H. L. A., Hinde, S., Bedendo, A., Walker, G. L., Noyes, J., Oddie, S., et al. (2022) · NIHR Open Research · doi:10.3310/nihropenres.13273.1 · Cited by 12
“Each analysis will account for the multiple confounding factors in this population (age, underlying diagnoses, comorbidities, outpatient attendance, socioeconomic status (Index of multiple deprivation)) 59 identified using causal inference methods 60–62 .”
MethodJanitz, A. E., Barber, R., Campbell, J. E., Xu, C., Pokala, H. R., Blanchard, J. W., & McNall‐Knapp, R. Y. (2022) · Cancer Epidemiology · doi:10.1016/j.canep.2022.102275 · Cited by 13
Liu, C., Chen, Y., Sun, B., Chen, H., Mustieles, V., Messerlian, C., Sun, Y., Meng, T., Lu, W., Pan, X., et al. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114737 · Cited by 12
Kreshpaj, B., Wegman, D., Burstrom, B., Davis, L., Hemmingsson, T., Håkansta, C., Jonsson, J., Johansson, G., Kjellberg, K., Martinez, N. S. S., et al. (2022) · Occupational and Environmental Medicine · doi:10.1136/oemed-2022-108604 · Cited by 12
Risk factors for COVID‐19 among Californians working outside the home, November 2020 ‐ May 2021
Wong, J., Cummings, K. J., Gibb, K., Rodriguez, A., Heinzerling, A., & Vergara, X. P. (2023) · American Journal of Industrial Medicine · doi:10.1002/ajim.23459 · Cited by 12
Mercury Exposure in Women of Reproductive Age in Rondônia State, Amazon Region, Brazil
Bello, T. C. D. S., Buralli, R. J., Cunha, M. P. L., Dórea, J. G., Díaz-Quijano, F. A., Guimarães, J. R. D., & Marques, R. C. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20065225 · Cited by 16
“The DAG’s (Figure 2) testable independence implications were evaluated using linear regression models and were not rejected (p > 0.05 for all tests), which was interpreted as an indicator of consistency between data and DAG [34].”
BackgroundInfluentialBollinger, L., Bartel, A., Weber, C., & Gehlen, H. (2023) · Animals · doi:10.3390/ani13101670 · Cited by 12
“All possible confounders were identified using R Package DAGitty software [43] and checked for association with exposure and outcome.”
MethodSharma, S., Castelnuovo, A. F. D., Costanzo, S., Persichillo, M., Panzera, T., Ruggiero, E., Curtis, A. D., Storto, M., Cavallo, P., Gianfagna, F., et al. (2023) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2023.2212879 · Cited by 12
Pakzad, R., Nedjat, S., Salehiniya, H., Mansournia, N., Etminan, M., Nazemipour, M., Pakzad, I., & Mansournia, M. A. (2023) · BMC Medical Research Methodology · doi:10.1186/s12874-023-01978-6 · Cited by 12
Sanchez, P., O’Donnell, C. T., Francisco, N., Santana, E. J., Moore, A. R., Pacheco-Navarro, A. E., Roque, J., Lebold, K. M., Parmer, C. M., Pienkos, S. M., et al. (2023) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202303-235oc · Cited by 12
Information Structures for Causally Explainable Decisions
Cox, L. A. (2021) · Entropy · doi:10.3390/e23050601 · Cited by 12
“It requires being able to use knowledge of choice sets, preferences (e.g., utility functions or goal states) for possible future outcomes, and estimated causal links (e.g., CPTs satisfying ICP) between current actions and probabilities of future outcomes to explain why the recommended course of action is best, as well…”
BackgroundMethodInfluentialGaio, V., Roquette, R., Monteiro, A., Ferreira, J., Lopes, D., Dias, C. M., & Nunes, B. (2021) · European Journal of Public Health · doi:10.1093/eurpub/ckab190 · Cited by 12
Maternal body composition and gestational weight gain in relation to asthma control during pregnancy
Stevens, D. R., Rohn, M. C. H., Hinkle, S. N., Williams, A., Kumar, R., Lipsky, L. M., Grobman, W. A., Sherman, S. J., Kanner, J., Chen, Z., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267122 · Cited by 12
Comparative study of the evolution of cancer gene duplications across fish
Baines, C., Meitern, R., Kreitsberg, R., & Sepp, T. (2022) · Evolutionary Applications · doi:10.1111/eva.13481 · Cited by 14
Gängler, S., Steiner, H., Gagesch, M., Guyonnet, S., Orav, E. J., von Eckardstein, A., Willett, W. C., & Bischoff-Ferrari, H. A. (2022) · Nutrients · doi:10.3390/nu14194145 · Cited by 12
“For each outcome, two models were run with minimal and full adjustments for potential confounders based on the directed acyclic graphs generated in DAGitty [34].”
MethodMirzayi, C. A., Renson, A., Zohra, F., Elsafoury, S., Geistlinger, L., Kasselman, L., Eckenrode, K., van de Wijgert, J. H. H. M., Loughman, A., Marques, F. Z., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.24.167353 · Cited by 12
“Consider including a directed acyclic graph showing the hypothesized causal relationships of interest.(16) Additionally discuss the potential for selection or survival bias (Item 6.”
BackgroundPrenatal exposure to ambient temperature and preterm birth: a historical cohort
Girgin, S., Erez, O., Nevo, D., Youssim, I., Kloog, I., & Raz, R. (2025) · International Journal of Epidemiology · doi:10.1093/ije/dyaf106 · Cited by 11
“According to the analysis of the DAG using DAGitty [38], the minimal set of variables to be adjusted for was: SES, ethnicity, locality, seasonality, and air pollution (Fig.”
Association of maternal attention deficit hyperactivity disorder and preterm birth: a cohort study
Hesselman, S., Wikman, A., Skoglund, C. B., Kallner, H. K., Skalkidou, A., Poromaa, I. S., & Wikström, A. (2020) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.16310 · Cited by 11
Cero, I., Mitchell, S. M., & Morris, C. S. (2021) · Suicide and Life-Threatening Behavior · doi:10.1111/sltb.12681 · Cited by 13
Jia, X., Qiang, M., Zhang, K., Han, Q., Wu, Y., & Chen, Y. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.795595 · Cited by 11
Race (black-white) and sex inequalities in tooth loss: A population-based study
Souza, L. H. T. E., Díaz-Quijano, F. A., Barros, M. B. D. A., & Lima, M. G. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276103 · Cited by 11
“10 for all tests), which was interpreted as an indicator of consistency between the DAG and the data [39, 45].”
MethodPeterson, A. K., Habre, R., Niu, Z., Amin, M., Yang, T., Eckel, S. P., Farzan, S. F., Lurmann, F. W., Pavlovic, N., Grubbs, B. H., et al. (2022) · Environmental Health · doi:10.1186/s12940-022-00925-0 · Cited by 11
“Covariates Covariates to include in multivariate models were identified a priori based on a review of the literature and visualized through Directed Acyclic Graphs (DAGs) [50].”
MethodEnvironmental Noise Exposure and Sleep Habits among Children in a Cohort from Northern Spain
Arregi, A., Lertxundi, A., Vegas, Ó., García‐Baquero, G., Ibarluzea, J. M., Anabitarte, A., Barroeta, Z., Jimeno-Romero, A., Subiza‐Pérez, M., & Lertxundi, N. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192316321 · Cited by 12
“’s DAGitty software [72] to identify its testable implications.”
BackgroundSeroprevalence of Hantavirus in Forestry Workers, Northern France, 2019–2020
Krug, C., Rigaud, E., Siby-Diakite, D., Bénézet, L., Papadopoulos, P., de Valk, H., Deffontaines, G., Septfons, A., & Reynes, J. (2023) · Viruses · doi:10.3390/v15020338 · Cited by 11
“Causal diagrams were made between hantavirus seropositivity and each factor of interest using DAGitty ([28,29]; diagrams not shown).”
MethodMoore, J., Subesinghe, M., Santaolalla, A., Green, M., Deere, H., van Hemelrijck, M., Lagergren, J., Chicklore, S., Maisey, N., Gossage, J., et al. (2023) · European Radiology · doi:10.1007/s00330-023-09482-7 · Cited by 10
So many variables, but what causes what?
CAT, C. D., & Unsworth, S. (2023) · Journal of Child Language · doi:10.1017/s0305000923000107 · Cited by 11
Vazquez‐Cardona, J., Bonnell, T. R., Mower, P. C., Medina, O. J., Jiskoot, H., & Logue, D. M. (2023) · Behavioral Ecology · doi:10.1093/beheco/arad030 · Cited by 11
“We applied the adjustmentSets function from the R package DAGitty (Textor et al. 2016), to confirm that our models can characterize the direct effect of Time on performance without confounds.”
MethodPatterns of Health Care Access and Use in an Urban American Indian and Alaska Native Population
Garcia, A. N., Venegas-Murillo, A. L., Martinez-Hollingsworth, A., Smith, L. V., Wells, K. B., Heilemann, M. V., Fischbach, L. A., Cummings, P. L., & Kuo, T. (2023) · Journal of Racial and Ethnic Health Disparities · doi:10.1007/s40615-023-01624-3 · Cited by 11
“Potential confounders/ control variables were identified using a priori information about known biologic or social causal relations and through the construction of directed acyclic graphs [14, 15].”
Salvatte, K., Farias, D. R., Normando, P., Berti, T. L., de Castro, I. R. R., & Kac, G. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.05.020 · Cited by 11
Angst, M., & Huber, M. N. (2023) · Policy Studies Journal · doi:10.1111/psj.12515 · Cited by 11
Bun, R. S., Bouziad, K. A., Daouda, O. S., Miliani, K., Eworo, A., Espinasse, F., Seytre, D., Casetta, A., Nérome, S., Temime, L., et al. (2023) · Infection Control and Hospital Epidemiology · doi:10.1017/ice.2023.248 · Cited by 11
“Utilizing alternative analytical approaches, such as directed acyclic graphs (DAGs), 40 could reveal previously unidentified relationships, guiding the development of more effective prevention strategies and enhancing HCW safety and patient care.”
MethodMyers, N. D., Brincks, A. M., & Lee, S. (2024) · Measurement in Physical Education and Exercise Science · doi:10.1080/1091367x.2024.2318355 · Cited by 11
Pulmonary function 3–6 months after acute COVID-19: A systematic review and multicentre cohort study
Cornelissen, M. E. B., Leliveld, A., Baalbaki, N., Gach, D., van der Lee, I., Nossent, E. J., Bloemsma, L. D., & der Zee, A. H. M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27964 · Cited by 11
“S1) [33].”
Barbieri, G., García-Larsen, V., Lundin, R., Fujii, R., Melotti, R., Gögele, M., Christopher, K. B., Cazzoletti, L., Pramstaller, P. P., Zanolin, M. E., et al. (2024) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2024.03.003 · Cited by 11
Rygaard, A., Jonsson, M., Wikström, A., Wendel, S. B., & Hesselman, S. (2024) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17830 · Cited by 12
“Confounding factors were identified using directed acyclic graphs (Figure S2), 22 which suggested the following minimal adjustments to estimate the effect of previous wound complication on OASI: BMI, age, induction, labour dystocia, operative vaginal delivery, fetal presentation at birth and…”
Ortuño, D., Martínez, C., Caneo, C., Paredes, F., Soto, M., González, M. I., Díaz, V., & Koller, G. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.05.010 · Cited by 11
A causal trait model for explaining foliar water uptake capacity
Matos, I. S., Rifai, S. W., Gouveia, W. F., Menor, I. O., Mantuano, D. G., & Rosado, B. H. P. (2024) · Journal of Vegetation Science · doi:10.1111/jvs.13258 · Cited by 11
Larvin, H., Baptiste, P. J., Gao, C., Muirhead, V., Donos, N., Pavitt, S. H., Kang, J. X., & Wu, J. (2024) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.14002 · Cited by 11
Effectiveness and Safety of an Emergency Department Code Sepsis Protocol: A Pragmatic Clinical Trial
Peltan, I. D., Bledsoe, J. R., Jacobs, J. R., Groat, D., Klippel, C., Adamson, M., Hooper, G. A., Tinker, N. J., Foster, R. A., Stenehjem, E. A., et al. (2024) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202403-286oc · Cited by 11
The effect of anxiety on all‐cause dementia: A longitudinal analysis from the Hunter Community Study
Khaing, K., Dolja‐Gore, X., Nair, B., Byles, J., & Attia, J. (2024) · Journal of the American Geriatrics Society · doi:10.1111/jgs.19078 · Cited by 13
“Three models were built: Model 1 — accounting for social demographic data (age and gender), Model 2 — adjusted model controlling all variables suggested by the DAG, and Model 3 — a sensitivity analysis where dementia and deaths identified within the first 5 years from baseline were excluded to eliminate the possibilit…”
InfluentialDrivers of interlineage variability in mitogenomic evolutionary rates in Platyhelminthes
Jakovlić, I., Ye, T., Zou, H., Zhu, F., Shi, Y., Ma, Y., Wang, G., Li, W. X., & Zhang, D. (2024) · Heredity · doi:10.1038/s41437-024-00712-2 · Cited by 11
“To conduct the causal inference analyses, we used dagitty (Textor et al. 2016), and then calculated causal effects using brms and lmekin following the methodology outlined in (Arif et al. 2022) (details in Supplementary fi le S1: Text S3).”
Allaouat, S., Yli‐Tuomi, T., Tiittanen, P., Kukkonen, J., Kangas, L., Mikkonen, S. J., Ngandu, T., Jousilahti, P., Siponen, T., Zeller, T., et al. (2024) · Environmental Research · doi:10.1016/j.envres.2024.119846 · Cited by 11
Managing nutrition-biodiversity trade-offs on coral reefs
Maire, E., Robinson, J. P. W., McLean, M. J., Arif, S., Zamborain‐Mason, J., Cinner, J. E., Ferse, S. C. A., Graham, N. A. J., Hoey, A. S., MacNeil, M. A., et al. (2024) · Current Biology · doi:10.1016/j.cub.2024.08.031 · Cited by 11
“We used the R package ‘dagitty’ 80 to test DAG-data consistency between our observational data and specified DAG.”
Early Maternal Prenatal Cannabis Use and Child Developmental Delays
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Xiong, W., Tang, X., Han, L., & Ling, L. (2025) · Human Reproduction Open · doi:10.1093/hropen/hoaf006 · Cited by 11
“We constructed the graph using online DAGitty version 3.1 to identify minimally sufficient adjustment sets of covariates (Textor et al. , 2016).”
InfluentialLim, A. H. W., Nitchingham, D., Bednarz, J., Bills, M., Lanka, L., Allen, B., Tan, A. B. T., Joshi, R., Hsieh, W., Crouch, B., et al. (2025) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2025.04.054 · Cited by 11
The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study
Lin, Y., Sayols-Baixeras, S., Baldanzi, G., Dekkers, K. F., Hammar, U., Nguyen, D. T., Nielsen, N., Eklund, A. C., Varotsis, G., Holm, J. B., et al. (2025) · Communications Medicine · doi:10.1038/s43856-025-00980-x · Cited by 12
“In the revised version one species, Dysosmobacter sp001916835 , was associated with two traits, while the other three were associated with one trait only.”
The future of epidemiology: methods or matter?
Ebrahim, S. B. J., Ferrie, J. E., & Smith, G. D. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyx032 · Cited by 13
“If a potential ‘cause’ cannot be manipulated, is it sensible to disregard it, relegating it to the ‘not suitable for epidemiology’ category? The use of directed acyclic graphs (DAGs) may, if properly constructed, aid causal thinking and help plan relevant analyses.(112) But DAGs and analyses may increasingly be constr…”
BackgroundTennant, P. W. G., Arnold, K. F., Berrie, L., Ellison, G. T. H., & Gilthorpe, M. S. (2017) · White Rose Research Online (University of Leeds, The University of Sheffield, University of York) · Cited by 11
Self-citationAmin, N. L., Kinsey, S. E., Feltbower, R. G., Kraft, J. K., Whitehead, E., Velangi, M., & James, B. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-027204 · Cited by 11
“Data will be collected and analysed in clinically relevant categories, while χ(2) tests and multivariable logistic regression models will be used to determine differences between groups adjusting for a relevant set of confounders identified using causal inference methods.(62) Potential confounders that will be assesse…”
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Kerulo, G., Kargas, N., Mills, D. S., Law, G., VanFleet, R., Faa-Thompson, T., & Winkle, M. Y. (2020) · People and Animals The International Journal of Research and Practice · doi:10.62845/if7vn9g · Cited by 11
Mzumara, G. W., Leopold, S. J., Marsh, K., Dondorp, A. M., Ohuma, E. O., & Mukaka, M. (2021) · Malaria Journal · doi:10.1186/s12936-021-03785-0 · Cited by 11
Wilson, S. F., Nudds, T. D., & de Vries, A. (2021) · Biological Conservation · doi:10.1016/j.biocon.2021.109370 · Cited by 11
Causal Considerations Can Inform the Interpretation of Surprising Associations in Medical Registries
Carmona‐Bayonas, A., Jiménez‐Fonseca, P., Gallego-Plazas, J., & Msaouel, P. (2021) · Cancer Investigation · doi:10.1080/07357907.2021.1999971 · Cited by 11
“Directed acyclic graphs (DAGs) were built using the Dagitty software (http://www.dagitty.net/) (58).”
MethodDiong, J. H. L., Lee, H., & Reed, D. (2023) · Discover Education · doi:10.1007/s44217-022-00027-6 · Cited by 11
“net/) [22] to obtain the minimallysufficient set of variables for adjustment, if any are needed, to determine the total effect.”
BackgroundAbasilim, C., Persky, V., & Turyk, M. E. (2023) · Hygiene and Environmental Health Advances · doi:10.1016/j.heha.2023.100047 · Cited by 11
“Using a directed acyclic graph and prior literature, we identified and included information on a wide range of potential confounders (Appendix Figure 1) (Greenland et al., 1999; Textor et al., 2016).”
MethodA Systematic Review: Is Porcine Kobuvirus Causing Gastrointestinal Disease in Young Pigs?
Eriksen, E. Ø. (2023) · Veterinary Sciences · doi:10.3390/vetsci10040286 · Cited by 11
Kapos, F. P., Vandeleur, D. M., Tham, S. W., Palermo, T. M., & Groenewald, C. B. (2023) · Pain · doi:10.1097/j.pain.0000000000003020 · Cited by 11
Time to treatment patterns of head and neck cancer patients before and during the Covid-19 pandemic
Tasoulas, J., Schrank, T. P., Smith, B. D., Agala, C. B., Kim, S., Sheth, S. H., Shen, C. J., Yarbrough, W. G., Hackman, T., & Sullivan, C. B. (2023) · Oral Oncology · doi:10.1016/j.oraloncology.2023.106535 · Cited by 11
Schaefer, S. M., Kaiser, A., Eichner, G., & Faßhauer, M. (2024) · Nutrition Journal · doi:10.1186/s12937-024-00926-4 · Cited by 12
“A directed acyclic graph (produced with the R package DAGitty [36] that shows hypothesized causal relationships underlying the association between sugar and CVD incidence was used to identify an appropriate set of confounding variables to assess an unconfounded effect estimate.”
MethodAssociation of serum fatty acid pattern with depression in U.S. adults: analysis of NHANES 2011–2012
Chen, H., Wang, J., Zheng, B., Xia, W., Tan, G., Wu, H., Wang, Y., Deng, Z., Wang, Y., Zhang, J., et al. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02142-9 · Cited by 11
“S2) [35].”
Buthmann, J. L., Finik, J. M., Ventura, G., Zhang, W., Shereen, A. D., & Nomura, Y. (2019) · Biological Psychology · doi:10.1016/j.biopsycho.2019.107716 · Cited by 10
“Following a review of the literature, a Directed Acyclic Graph (DAG) was made to represent the theorized causal pathway between PNMS, PNMD and offspring ANS function (as represented by EDA measures) (Textor et al., 2016).”
Methodvan Bentem, K., Lashley, E. E. L. O., Bos, M., Eikmans, M., Heidt, S., Claas, F. H. J., le Cessie, S., & van der Hoorn, M. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-027469 · Cited by 11
“All possible factors are visualised to provide insight into their effects by a directed acyclic graph (figure 2) with the use of DAGitty program.(22) According to this DAG, adjustment for age, ethnicity, plurality and mode of conception is necessary to minimise the effect confounding.”
Smith, L., Glaser, A., Greenwood, D. C., & Feltbower, R. G. (2020) · Cancer Epidemiology · doi:10.1016/j.canep.2020.101711 · Cited by 11
Cox, J., Ryan, P., Burkle, J. W., Jandarov, R., Mendell, M. J., Hershey, G. K. K., LeMasters, G. K., & Reponen, T. A. (2020) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000101 · Cited by 14
Amazouz, H., de Lauzon‐Guillain, B., Bourgoin‐Heck, M., Just, J., Beydon, N., Lezmi, G., Rancière, F., & Momas, I. (2020) · Allergy · doi:10.1111/all.14568 · Cited by 11
da Silva, M. T., Mujica-Coopman, M. F., Figueiredo, A. C. C., Hampel, D., Vieira, L. S., Farias, D. R., Shahab‐Ferdows, S., Allen, L. H., Alex Brito, O., Lamers, Y., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-77231-7 · Cited by 11
Li, J., Du, Y., Liu, Y., Du, J., Zhang, R., Qu, P., Yan, H., Wang, D., & Dang, S. (2021) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-021-04154-0 · Cited by 15
“3) (26) was adopted to screen the minimal su cient set of covariates.”
MethodEvolutionary Personality Psychology
Lewis, D. M. G., Al-Shawaf, L., & Buss, D. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.022 · Cited by 11
Bentouhami, H., Casas, L., & Weyler, J. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19052888 · Cited by 31
“0’ for the relationship between recent exposure to ETS and asthma diagnosis (Figure 1) [15].”
BackgroundStrain on the ICU resources and patient outcomes in the COVID-19 pandemic
Stattin, K., Frithiof, R., Hultström, M., Lipcsey, M., & Kawati, R. (2022) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000001760 · Cited by 11
Kayyal-Tarabeia, I., Blank, M., Zick, A., & Agay‐Shay, K. (2022) · Environmental Research · doi:10.1016/j.envres.2022.114471 · Cited by 14
Petersen, M. W., Carstensen, T. B. W., Frostholm, L., Wellnitz, K. B., Ørnbøl, E., Lamm, T. T., Dantoft, T. M., Eplov, L. F., Jørgensen, T., & Fink, P. (2022) · Scientific Reports · doi:10.1038/s41598-022-24213-6 · Cited by 11
Ferguson, K., McCann, M., Katikireddi, S. V., Thomson, H., Green, M. J., Smıth, D. J., & Lewsey, J. (2019) · International Journal of Epidemiology · doi:10.1093/ije/dyz220 · Cited by 11
Timarán, D. A. V., Arango‐Sabogal, J. C., Reyes-Vélez, J., & Maldonado-Estrada, J. G. (2020) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2020.105202 · Cited by 10
Ng, L. H., Hart, M. J., Dingle, S. E., Milte, C. M., Livingstone, K. M., Shaw, J. E., Magliano, D. J., McNaughton, S. A., & Torres, S. J. (2022) · British Journal Of Nutrition · doi:10.1017/s000711452200304x · Cited by 10
“Confounders included in the model were determined by the use of a directed acyclic graph (DAG) developed using the online tool DAGitty (30) (Fig.”
MethodWu, I., Liu, C., Cheng, W., Lin, T., Chen, H., Chen, P., Wu, R., Huang, C., Hsiung, C. A., & Hsu, C. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00322-8 · Cited by 11
“The biasing pathway is presented in red [34]”
BackgroundNishimura, T., Takahashi, N., Okumura, A., Harada, T., Iwabuchi, T., Nakayasu, C., Rahman, M. S., Uchiyama, S., Wakuta, M., Nomura, Y., et al. (2023) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13529 · Cited by 10
Dietary patterns, lung function and asthma in childhood: a longitudinal study
Talaei, M., Emmett, P. M., Granell, R., Tabatabaeian, H., Northstone, K., Bergström, A., & Shaheen, S. O. (2023) · Respiratory Research · doi:10.1186/s12931-023-02383-9 · Cited by 10
“We selected known potential confounding factors from the existing literature [39] and by using a directed acyclic graph approach [40]; these included multiple individual and area-based indicators of socioeconomic status (SES) (see Additional file 1: Fig.”
MethodJing, H., Teng, Y., Chacha, S., Wang, Z., Shi, G., Mi, B., Zhang, B., Cai, J., Liu, Y., Li, Q., et al. (2023) · Nutrients · doi:10.3390/nu15194183 · Cited by 10
“Based on currently available professional knowledge, a directed acyclic graph (DAG) was used to determine the causal relationship among the 10 confounding variables [41].”
MethodMafla, A. C., Orozco‐Tovar, A. E., Ortiz‐Gómez, F., Ortiz‐Pizán, Á. J., González‐Ruano, A. V., & Schwendicke, F. (2023) · International Journal of Paediatric Dentistry · doi:10.1111/ipd.13142 · Cited by 11
Nagarajan, S., Rosenbaum, J. E., & Joks, R. O. (2024) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2024.02.001 · Cited by 11
Xie, X., Huang, L.-Y., Cheng, G., Liu, D., Hu, F., Zhang, J., Han, G., Liu, X.-C., Wang, J., Zhou, J. H., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231186 · Cited by 10
“Prior to analysis, potential confounders were pre-selected and defined using DAGitty version 3.0, utilizing a directed acyclic graph (DAG) [37].”
InfluentialMerle, R., Hoedemaker, M., Knubben‐Schweizer, G., Metzner, M., Müller, K., & Campe, A. (2024) · Animals · doi:10.3390/ani14091385 · Cited by 10
“After identifying the target variable, a causal directed acyclic graph (DAG) (http://www. dagitty.net/ ( accessed on 25.05.2023)) [ 16] was created, including all known and expected influence factors on this outcome, from existing and/or expert knowledge.”
BackgroundMethodInfluentialWu, W., Chen, D., Ruan, X., Wu, G., Deng, X., Lawrence, W. R., Lin, X., Li, Z., Wang, Y., Lin, Z., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.025 · Cited by 10
“To identify potential confounders, we generated a directed acyclic graph (DAG) using DAGitty’s online tool [42] (available at www.dagitty.net) (Figure S1).”
Organophosphate ester flame retardant chemicals and maternal depression during pregnancy
Hernandez‐Castro, I., Eckel, S. P., Howe, C. G., Aung, M. T., Kannan, K., Robinson, M., Foley, H. B., Yang, T., Vigil, M. J., Chen, X., et al. (2024) · Environmental Research · doi:10.1016/j.envres.2024.119581 · Cited by 10
Mitchell, H. K., Seaton, S. E., Leahy, C., Mustafa, K., Buckley, H., Davis, P., Feltbower, R. G., & Ramnarayan, P. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102776 · Cited by 12
Salamanca‐Fernández, E., Espín-Moreno, L., Olivas-Martínez, A., Pérez-Cantero, A., Martín-Rodríguez, J. L., Poyatos, R. M., Barbone, F., Rosolen, V., Mariuz, M., Ronfani, L., et al. (2024) · Toxics · doi:10.3390/toxics12090642 · Cited by 13
“Potential confounders of phthalate–BDNF behavior associations were identified a priori based on causal scientific knowledge [59].”
BackgroundZheng, P. Z., Scheffler, A., Ewing, S. K., Hue, T. F., Jones, S. B., Morshed, S., Mehling, W. E., Espin, A. T., Galivanche, A. R., Lotz, J. C., et al. (2025) · The Spine Journal · doi:10.1016/j.spinee.2024.12.029 · Cited by 14
“1, which includes all exposures along with a set of nodes and directed edges, a minimally sufficient adjustment set (MSAS) was identified for the total effect of each exposure variable separately using the R package daggity (v. 3.1) [48].”
InfluentialCheetham, N. J., Bowyer, V., García, M. P., Bowyer, R. C. E., Carpentieri, J., Guise, A., Thompson, E. J., Sudre, C. H., Molteni, E., Antonelli, M., et al. (2025) · BMJ Public Health · doi:10.1136/bmjph-2024-001166 · Cited by 9
Kakampakou, L., Stokes, J., Höhn, A., de Kamps, M., Lawniczak, W., Arnold, K. F., Hensor, E. M. A., Heppenstall, A. J., & Gilthorpe, M. S. (2025) · BMC Medical Research Methodology · doi:10.1186/s12874-025-02504-6 · Cited by 10
“To simulate multivariate normal data we used the R package dagitty [42], which takes a specified DAG to obtain its implied correlation matrix, from which multivariate Normal data are generated.”
InfluentialSelf-citationSchipper, M. C., Jaddoe, V. W. V., Bekkers, E. L., Mulders, A. G. M. G. J., & Gaillard, R. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.04.006 · Cited by 10
Zeng, X., Jiang, Y., Liu, Z., Yang, H., Song, H., Li, C., & Fu, P. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.038951 · Cited by 11
“21 Finally, for analyses of death, we adjusted for confounders including age, sex, race and ethnicity, educational level, depression, employment status, eGFR stage and Townsend deprivation index, while for analyses on CVD, age, sex, diabetes, hypertension, GFR stage, and smoking status were…”
Functional evaluation of mandibular reconstruction with bone free flap. A GETTEC study
Atallah, S., Bozec, A., Ransy, P., Davrou, J., Longis, J., Humbert, M., Brenet, E., Schultz, P., Damecourt, A., Guily, J. L. S., et al. (2020) · European Annals of Otorhinolaryngology Head and Neck Diseases · doi:10.1016/j.anorl.2020.08.005 · Cited by 10
Park, E., Lee, H. J., Choi, H. J., Ahn, Y. H., Han, K. H., Kim, S. H., Cho, H., Shin, J. I., Lee, J. H., Park, Y. S., et al. (2021) · Pediatric Nephrology · doi:10.1007/s00467-021-05054-3 · Cited by 10
Enarsson, M., Feldreich, T., Byberg, L., Nowak, C., Lind, L., & Ärnlöv, J. (2021) · Sports Medicine - Open · doi:10.1186/s40798-021-00343-5 · Cited by 12
Metadata
- Authors
- Textor, J., van der Zander, B., Gilthorpe, M. S., Liśkiewicz, M., & Ellison, G. T. H.
- Affiliations
- Radboud University Medical Center (NL)
- University of Leeds (GB)
- University of Lübeck (DE)
- Corresponding author
- Textor, Johannes
- Venue
- International Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-01-15
- Volume
- 45
- Issue
- 6
- Pages
- dyw341
- ISSN
- 0300-5771 (ISSN-L)
- 1464-3685
- OpenAlex
- W2576536258
- Cited by
- 2,295
- References
- 19
- Citations by year
- 2026: 156 · 2025: 409 · 2024: 451 · 2023: 392 · 2022: 323 · 2021: 256 · 2020: 201 · 2019: 74 · 2018: 22 · 2017: 6
- FWCI
- 35.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Physical Sciences › Computer Science › Artificial Intelligence › Bayesian Modeling and Causal Inference
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Keywords
- directed acyclic graphs, causal inference, R package, adjustment sets, confounding
- MeSH terms
- Data Interpretation, Statistical, Epidemiologic Methods, Humans, Software, Bias, Causality, Confounding Factors, Epidemiologic
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