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Nonspecificity of the Limulus Amebocyte Lysate Test: Positive Reactions with Polynucleotides and Proteins
Abstract
A positive limulus amebocyte lysate (LAL) test has been considered specific for the presence of bacterial endotoxins. The present studies indicated that a variety of compounds such as thrombin, thromboplastin, polyriboinosinic-polyribocytidylic acid [poly (I) · poly (C)], polyriboadenylic-polyribouridylic acid [poly (A) · poly (U)] and ribonuclease all resulted in a positive LAL test. In addition, two other pyrogenic compounds, human leukocytic pyrogen and dextrans, reacted negatively in this assay. When bacterial endotoxins are known to be present, the LAL test remains the most sensitive assay for their measurement. However, it is essential to take the nonspecificity of the reaction into account when interpreting positive LAL tests of unknown solutions.
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Citations
Cited by
Endotoxemia in Human Septic Shock
Danner, R. L., Elin, R. J., Hosseini, J. M., Wesley, R. A., Reilly, J. M., & Parillo, J. E. (1991) · Chest · doi:10.1378/chest.99.1.169 · Cited by 656
Self-citationEndotoxin and Bacteria in Portal Blood
Jacob, A. I., Goldberg, P. K., Bloom, N., Degenshein, G. A., & Kozinn, P. J. (1977) · Gastroenterology · doi:10.1016/s0016-5085(77)80025-5 · Cited by 393
Endotoxemia: Methods of detection and clinical correlates
Hurley, J. C. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.2.268 · Cited by 318
Adriaens, P. A., Edwards, C. A., De Boever, J. A., & Loesche, W. J. (1988) · Journal of Periodontology · doi:10.1902/jop.1988.59.8.493 · Cited by 287
Immunity targeting common core antigens of Gram-negative bacteria
Tyler, J. W., Cullor, J. S., Spier, S. J., & Smith, B. P. (1990) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.1990.tb00870.x · Cited by 33
Metadata
- Authors
- Elin, R. J., & Wolff, S. M.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1973-09-01
- Volume
- 128
- Issue
- 3
- Pages
- 349-352
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W1989905661
- Cited by
- 216
- References
- 0
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Elin, R. J., & Wolff, S. M. (1973). Nonspecificity of the Limulus Amebocyte Lysate Test: Positive Reactions with Polynucleotides and Proteins. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/128.3.349
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