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Response of Man to Infection with Vibrio cholerae. I. Clinical, Serologic, and Bacteriologic Responses to a Known Inoculum
Abstract
The spectrum of illness and the immunologic response produced by cholera in volunteers were studied. The strains of Vibrio cholerae used were classical Inaba 569B and classical Ogawa 395. An oral dose of 108 organisms in buffered saline was required to induce the diarrhea of cholera. When given with live organisms, NaHCO3 lowered the infecting dose from 108 to 104 organisms. Clinical manifestations of infection varied from culturally positive formed stools to “rice water” diarrhea. Severe diarrhea did not have an explosive onset but rather progressively increased in volume during a 24-hr period. In 45 % of cases the stool was positive for V. cholerae before the onset of diarrhea. Titers of vibriocidal antibody rose after diarrhea, peaked the second week after challenge, and rapidly fell during the next four weeks.
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Citations
Cited by
Hyperinfectivity: A Critical Element in the Ability of V. cholerae to Cause Epidemics?
Hartley, D. M., Morris, J. G., & Smith, D. L. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0030007 · Cited by 429
Reduction of cholera in Bangladeshi villages by simple filtration
Colwell, R. R., Huq, A., Islam, M. S., Aziz, K. M. A., Yunus, M., Khan, N. H., Mahmud, A., Sack, R. B., Nair, G. B., Chakraborty, J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0237386100 · Cited by 382
Bik, E. M., Bunschoten, A. E., Gouw, R. D., & Mooi, F. R. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb06993.x · Cited by 253
Huq, A., Yunus, M., Sohel, S. S., Bhuiya, A., Emch, M., Luby, S. P., Russek-Cohen, E., Nair, G. B., Sack, R. B., & Colwell, R. R. (2010) · mBio · doi:10.1128/mbio.00034-10 · Cited by 87
Intervention studies and the definition of dominant transmission routes
BRISCOE, J. (1984) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113909 · Cited by 86
Metadata
- Authors
- Cash, R. A., Music, S. I., Libonati, J. P., Snyder, M. J., Wenzel, R. P., & Hornick, R. B.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1974-01-01
- Volume
- 129
- Issue
- 1
- Pages
- 45-52
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2073943816
- Cited by
- 329
- References
- 0
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Response of Man to Infection with Vibrio cholerae. I. Clinical, Serologic, and Bacteriologic Responses to a Known Inoculum. https://app.cochat.ai/papers/10.1093/infdis/129.1.45
- The paper
- Cash, R. A., Music, S. I., Libonati, J. P., Snyder, M. J., Wenzel, R. P., & Hornick, R. B. (1974). Response of Man to Infection with Vibrio cholerae. I. Clinical, Serologic, and Bacteriologic Responses to a Known Inoculum. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/129.1.45
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
