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Cited by 320

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Genetics of Resistance to Infection with Salmonella typhimurium in Mice

Plant, J., Glynn, A. A.·1976·Journal of Infectious Diseases

Abstract

Eight strains of inbred mice fell into two sharply defined groups. Four strains (CBA, A/JAX, C3H/He, and DBA/2) were resistant (LD50, greater than 10(5)) to Salmonella typhimurium C5 given subcutaneously. The other four strains (Balb/c, C57BL, B10.D2 [new line], and DBA/1) were susceptible (LD50, less than 10). No intermediate resistance was seen. Examination of the F1, F2, and parental backcross generations bred from matings of CBA and Balb/c mice showed that resistance behaved as a simple Mendelian dominant. Resistance was not linked to H-2 genes, and no useful marker has yet been found. However, as previously demonstrated in the parent strains, resistance in the hybrids was related to the ability to produce a good delayed-type hypersensitivity reaction to an extract of S. typhimurium.

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Metadata

Authors
Plant, J., & Glynn, A. A.
Venue
Journal of Infectious Diseases
Published
1976-01-01
Volume
133
Issue
1
Pages
72-78
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
OpenAlex
W2064567333
Cited by
320
References
8
FWCI
27.12
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Genetics of Resistance to Infection with Salmonella typhimurium in Mice. https://app.cochat.ai/papers/10.1093/infdis/133.1.72
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Plant, J., & Glynn, A. A. (1976). Genetics of Resistance to Infection with Salmonella typhimurium in Mice. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/133.1.72

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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