The DOI matches its Crossref record.
Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex Virus
Abstract
A large variety of antiherpes compounds was compared for their inhibitory activity against laboratory strains and clinical isolates of herpes simplex virus (HSV) type 1 and type 2. From studies performed in primary rabbit kidney cell cultures, six, E-5-(2-bromovinyl)-2'-deoxyuridine, E-5-(2-iodovinyl)-2'-deoxyuridine, 5-vinyl-2'-deoxyuridine, 2'-fluoro-5-iodoaracytosine, acycloguanosine, and 5-iodo-2'-deoxycytidine, emerged as the most potent and selective antiherpes agents. For HSV type 1, the 50% inhibitory doses (ID50) were 0.008, 0.012, 0.018, 0.017, 0.04, and 0.06 micrograms/ml, respectively; those for HSV type 2 were 1, 2, 0.1, 0.05, 0.04, and 0.3 microgram/ml, respectively. These compounds did not inhibit host-cell metabolism or replication of vaccinia virus except at concentrations 100--10,000 times greater than the ID50 for any HSV. All were significantly less inhibitory for a thymidine kinase (TK)-deficient mutant of HSV type 1 than for normal strains, suggesting that phosphorylation by virus-induced TK was required to produce specific inhibition of HSV replication.
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Cited by
Design and Synthesis of Hydroxyferroquine Derivatives with Antimalarial and Antiviral Activities
Biot, C., Daher, W., Chavain, N., Fandeur, T., Khalife, J., Dive, D., & De Clercq, E. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm0601856 · Cited by 320
Self-citationINTRAVITREAL INJECTION OF THERAPEUTIC AGENTS
PEYMAN, G. A., LAD, E. M., & MOSHFEGHI, D. M. (2009) · Retina · doi:10.1097/iae.0b013e3181a94f01 · Cited by 255
Zhu, W., Ooi, V. E. C., Chan, P. K. S., & Ang Jr., P. O. (2003) · Biochemistry and Cell Biology · doi:10.1139/o02-169 · Cited by 79
Metadata
- Authors
- De Clercq, E., Descamps, J., Verhelst, G., Walker, R. T., Jones, A. S., Torrence, P. F., & Shugar, D.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1980-05-01
- Volume
- 141
- Issue
- 5
- Pages
- 563-574
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2142992472
- Cited by
- 604
- References
- 0
- FWCI
- 49.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- De Clercq, E., Descamps, J., Verhelst, G., Walker, R. T., Jones, A. S., Torrence, P. F., & Shugar, D. (1980). Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex Virus. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/141.5.563
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