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Duration of Infection-Derived Immunity to Cholera
Abstract
Four volunteers were rechallenged with Vibrio cholerae (10(6) classical Ogawa 395 organisms) 33-36 months after their initial induced cholera infection; none of the four veterans and four of five control volunteers developed diarrhea (P = 0.04). All control subjects, but only one veteran, had positive coprocultures. Three of the four veterans had significant levels of serum IgG antitoxin before challenge, but none had measurable intestinal levels of secretory IgA antitoxin. Significant rises in levels of serum vibriocidal and antitoxic antibody occurred in all control subjects and in two veterans, who also manifested rises in levels of intestinal secretory IgA antitoxin. The impressive duration of infection-derived immunity suggests that the most promising approach to development of cholera vaccines may be to mimic natural immunity with orally administered, attenuated strains of V. cholerae.
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Cited by
Levine, M., Herrington, D., Losonsky, G., Tall, B., Kaper, J., Ketley, J., Tacket, C., & Cryz, S. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90120-1 · Cited by 323
Self-citationContrasting Epidemiology of Cholera in Bangladesh and Africa
Sack, D. A., Debes, A. K., Ateudjieu, J., Bwire, G., Ali, M., Ngwa, M. C., Mwaba, J., Chilengi, R., Orach, C. C., Boru, W., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab440 · Cited by 38
Metadata
- Authors
- Levine, M. M., Black, R. E., Clements, M. L., Cisneros, L., Nalin, D. R., & Young, C. R.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1981-06-01
- Volume
- 143
- Issue
- 6
- Pages
- 818-820
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2128848335
- Cited by
- 243
- References
- 0
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Duration of Infection-Derived Immunity to Cholera. https://app.cochat.ai/papers/10.1093/infdis/143.6.818
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- Levine, M. M., Black, R. E., Clements, M. L., Cisneros, L., Nalin, D. R., & Young, C. R. (1981). Duration of Infection-Derived Immunity to Cholera. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/143.6.818
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
