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Serum Antibody Response to Toxins A and B of Clostridium difficile
Abstract
An enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to toxins A and B of Clostridium difficile was developed. Serum samples from 340 patients were tested for determination of the age-related prevalence of antitoxin. Antibody to toxin A was present in 64% of patients more than two years old and antibody to toxin B in 66% of patients more than six months old. A strongly positive ELISA value correlated with the presence of cytotoxicity-neutralizing antibody (P less than 0.001). Strongly positive ELISA values were obtained more commonly in convalescent sera from 16 patients with C difficile-induced colitis than in sera from the control population (antibody to toxin A, P less than 0.05; antibody to toxin B, P less than 0.001). Testing of paired sera revealed significant increases in the titer of IgG antibody to toxin A or B. Ten of the 16 patients with colitis had IgM titers of greater than or equal to 1:160 to one or both toxins. The data presented suggest that antibodies to toxins A and B are present in the majority of older children and adults and that patients with C difficile-induced disease develop serologic responses to one or both toxins.
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Cited by
Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections
Surawicz, C. M., Brandt, L. J., Binion, D. G., Ananthakrishnan, A. N., Curry, S. R., Gilligan, P. H., McFarland, L. V., Mellow, M., & Zuckerbraun, B. S. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.4 · Cited by 1,645
Bartlett, J. G. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/18.supplement_4.s265 · Cited by 309
Self-citationThe emergence of Clostridium difficile as a pathogen of food animals
Songer, J. G. (2004) · Animal Health Research Reviews · doi:10.1079/ahr200492 · Cited by 117
Metadata
- Authors
- Viscidi, R., Laughon, B. E., Yolken, R., Bo-Linn, P., Moench, T., Ryder, R. W., & Bartlett, J. G.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-07-01
- Volume
- 148
- Issue
- 1
- Pages
- 93-100
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2033506368
- Cited by
- 204
- References
- 0
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Serum Antibody Response to Toxins A and B of Clostridium difficile. https://app.cochat.ai/papers/10.1093/infdis/148.1.93
- The paper
- Viscidi, R., Laughon, B. E., Yolken, R., Bo-Linn, P., Moench, T., Ryder, R. W., & Bartlett, J. G. (1983). Serum Antibody Response to Toxins A and B of Clostridium difficile. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/148.1.93
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