The DOI matches its Crossref record.
Biosynthesis of Androgen from Cortisol by a Species of Clostridium Recovered From Human Fecal Flora
Abstract
A hitherto unknown species of Clostridium, provisionally designated strain 19, was isolated from the fecal flora of a healthy human adult. This strain synthesizes a constitutive desmolase that cleaves the side chain of cortisol to form 11 beta-hydroxy-4-androstene-3,17-dione. The enzymatic conversion is best demonstrated in supplemented peptone broth and in prereduced brain-heart infusion broth. The fecal concentration of strain 19 is 10(7)-10(8) cells/g. The strain adapts with difficulty to growth on Mueller-Hinton agar and Columbia agar base; colony formation is enhanced by the addition of 5% sheep blood. The organism is sensitive to penicillin G and resistant to tetracycline, chloramphenicol, clindamycin, and erythromycin.
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“For example, the hippocampus is highly responsive to glucocorticoids (Lupien et al., 2005), which can be metabolized by the microbiota (Ridlon et al., 2013) into the steroid and pro-hormone 11β-hydroxy-androstenedione (11β-OHAD) (Bokkenheuser et al., 1984;Ridlon et al., 2013).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Bokkenheuser et al., 1984
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Metadata
- Authors
- Bokkenheuser, V. D., Morris, G. N., Ritchie, A. E., Holdeman, L. V., & Winter, J.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1984-04-01
- Volume
- 149
- Issue
- 4
- Pages
- 489-494
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W1993920096
- Cited by
- 48
- References
- 0
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 1 · 2023: 2 · 2021: 3 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- androgen production, cortisol, Clostridium, bacterial isolation, bacterial growth requirements, antibiotic susceptibility
- MeSH terms
- Androstenedione, Anti-Bacterial Agents, Clostridium, Culture Media, Feces, Humans, Hydrocortisone, Lyases, Oxygen
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