The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effects of Ampicillin and Corticosteroids on Brain Water Content, Cerebrospinal Fluid Pressure, and Cerebrospinal Fluid Lactate Levels in Experimental Pneumococcal Meningitis
Abstract
A study was made of the effects of antibiotics and corticosteroids on parameters that reflect brain dysfunction and potential neurological damage in experimental pneumococcal meningitis in rabbits. Brain water content was 398 +/- 10 g/100 g dry weight in normal rabbits and 410 +/- 11 g in rabbits after 24 hr of infection (P less than .001). Cerebrospinal fluid (CSF) lactate levels increased from 16.3 +/- 3.4 mg/dl to 69.5 +/- 28.2 mg/dl (P less than .001), and CSF pressure increased by +8.3 +/- 3.6 mm Hg (P less than .005) over the same interval. Antibiotic therapy with ampicillin sterilized CSF and normalized CSF pressure and brain water content in all animals within 24 hr, while CSF lactate levels remained elevated. Administration of methyl prednisolone, 30 mg/kg, or dexamethasone, 1 mg/kg, 15 and 22 hr after infection completely reversed the development of brain edema, but only dexamethasone also significantly reduced the increase in CSF lactate level (43.8 +/- 12.3 mg/dl) and CSF pressure (+1.8 +/- 2.7 mm Hg). Methyl prednisolone did not significantly affect pressure or lactate levels.
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Citations
Cites
Potency and duration of action of glucocorticoids
Meikle, A. W., & Tyler, F. H. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90233-9 · Cited by 319
Cited by
Hao (2015) · doi:10.1002/14651858 · Cited by 11,321
Corticosteroids for acute bacterial meningitis
Brouwer, M. C., McIntyre, P., Prasad, K., & van de Beek, D. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004405.pub5 · Cited by 809
Ramesh, G., MacLean, A. G., & Philipp, M. T. (2013) · Mediators of Inflammation · doi:10.1155/2013/480739 · Cited by 639
Pathogenesis and Pathophysiology of Pneumococcal Meningitis
Mook-Kanamori, B. B., Geldhoff, M., van der Poll, T., & van de Beek, D. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00008-11 · Cited by 492
McGill, F., Heyderman, R. S., Michael, B. D., Defres, S., Beeching, N. J., Borrow, R., Glennie, L., Gaillemin, O., Wyncoll, D., Kaczmarski, E., et al. (2016) · Journal of Infection · doi:10.1016/j.jinf.2016.01.007 · Cited by 254
Metadata
- Authors
- Tauber, M. G., Khayam-Bashi, H., & Sande, M. A.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-03-01
- Volume
- 151
- Issue
- 3
- Pages
- 528-534
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2142095560
- Cited by
- 254
- References
- 1
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effects of Ampicillin and Corticosteroids on Brain Water Content, Cerebrospinal Fluid Pressure, and Cerebrospinal Fluid Lactate Levels in Experimental Pneumococcal Meningitis. https://app.cochat.ai/papers/10.1093/infdis/151.3.528
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- Tauber, M. G., Khayam-Bashi, H., & Sande, M. A. (1985). Effects of Ampicillin and Corticosteroids on Brain Water Content, Cerebrospinal Fluid Pressure, and Cerebrospinal Fluid Lactate Levels in Experimental Pneumococcal Meningitis. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/151.3.528
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