The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever
Abstract
Interleukins (IL) -1 beta and -1 alpha and tumor necrosis factor (TNF-alpha) were measured by radioimmunoassay in plasma samples from 44 healthy individuals, 15 patients in septic shock, and 6 volunteers infused with endotoxin. Plasma IL-1 alpha levels were low (40 pg/ml) or undetectable in all situations. In 67% of the healthy subjects, plasma IL-1 beta levels were less than 70 pg/ml. Septic patients had higher plasma IL-1 beta levels (120 +/- 17 pg/ml, P = .001); those of surviving patients were higher than those of patients who died (P = .05). Plasma TNF-alpha concentrations in septic individuals were elevated (119 +/- 30 pg/ml) and correlated with severity of illness (r = .73, P = .003), but no correlation was observed between plasma IL-1 beta and TNF-alpha concentrations in individual samples. Infusion of endotoxin caused a twofold elevation of IL-1 beta, from a baseline of 35 +/- 5 pg/ml to a maximum of 69 +/- 27 pg/ml at 180 min (P less than .05). Peak TNF-alpha levels after endotoxin infusion were 15 times higher than IL-1 beta levels, were attained more rapidly (90 min), and as with the septic patients, did not correlate with IL-1 beta levels. These data support the concept that plasma IL-1 beta and TNF-alpha concentrations are regulated independently and are associated with different clinical outcomes.
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Cites
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Detection of circulating tumor necrosis factor after endotoxin administration
Michie, H. R., Manogue, K. R., Spriggs, D. R., Revhaug, A., O'Dwyer, S., Dinarello, C. A., Cerami, A., Wolff, S. M., & Wilmore, D. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806093182301 · Cited by 1,677 · cited 2×
“the study, preparation and administration of the endotoxin, supervision procedures, and emergency precautions have been reported in detail previously [5].”
BackgroundSelf-citation
Cited by
Multiple Organ Failure Pathophysiology and Potential Future Therapy
DEITCH, E. A. (1992) · Annals of Surgery · doi:10.1097/00000658-199208000-00002 · Cited by 1,380
Abraham, E. (1998) · The Lancet · doi:10.1016/s0140-6736(00)80009-4 · Cited by 624
Dangerous dogmas in medicine: the nonthyroidal illness syndrome
De Groot, L. J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5364 · Cited by 505
Pyroptosis-Induced Inflammation and Tissue Damage
Vasudevan, S. O., Behl, B., & Rathinam, V. A. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101781 · Cited by 412
Tilders, F. J. H., DeRuk, R. H., Van Dam, A.-M., Vincent, V. A. M., Schotanus, K., & Persoons, J. H. A. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90010-8 · Cited by 277
Metadata
- Authors
- Cannon, J. G., Tompkins, R. G., Gelfand, J. A., Michie, H. R., Stanford, G. G., van der Meer, J. W. M., Endres, S., Lonnemann, G., Corsetti, J., Chernow, B., Wilmore, D. W., Wolff, S. M., Burke, J. F., & Dinarello, C. A.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-01-01
- Volume
- 161
- Issue
- 1
- Pages
- 79-84
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2093816949
- Cited by
- 751
- References
- 2
- FWCI
- 57.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cannon, J. G., Tompkins, R. G., Gelfand, J. A., Michie, H. R., Stanford, G. G., van der Meer, J. W. M., Endres, S., Lonnemann, G., Corsetti, J., Chernow, B., Wilmore, D. W., Wolff, S. M., Burke, J. F., & Dinarello, C. A. (1990). Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/161.1.79
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
