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Intestinal Microsporidiosis in Human Immunodeficiency Virus-Infected Patients with Chronic Unexplained Diarrhea: Prevalence and Clinical and Biologic Features
Abstract
Eighteen patients infected with human immunodeficiency virus and with chronic unexplained diarrhea were prospectively studied to investigate the prevalence and clinical and biologic features of intestinal microsporidiosis. All patients underwent extensive evaluation for bacterial, viral, and parasitic pathogens. Enterocytozoon bieneusi was found in 9 patients (50%; 95% confidence interval, 27-73) in stools and duodenal and jejunal biopsies. In 8 patients, it was the sole pathogen found. Other pathogens were also isolated from the intestinal tracts of 4 patients, but diarrhea remained unexplained in 6. Patients with intestinal microsporidiosis had significantly lower mean Karnofsky scores (69.4 vs. 85.5, P = .009), CD4 cell counts (18.6 vs. 209.8/microL, P = .02), and D-xylose absorption tests (0.13 vs. 0.36 g/L, P < .001) than did patients without intestinal microsporidiosis. Intestinal microsporidiosis appears to be a frequent cause of unexplained chronic diarrhea in patients with AIDS and is associated with diminished D-xylose absorption.
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E. bieneusi infection was not successfully cured using albendazole (800 mg daily for 28 days), with parasites not completely cleared in small-bowel biopsies of the patients.
“However, E. bieneusi infection was not successfully cured using albendazole (800 mg daily for 28 days), with parasites not completely cleared in small-bowel biopsies of the patients [299–302].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [299]
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286
Metadata
- Authors
- Molina, J.-M., Sarfati, C., Beauvais, B., Lemann, M., Lesourd, A., Ferchal, F., Casin, I., Lagrange, P., Modigliani, R., Derouin, F., & Modal, J.
- Affiliations
- Hôpital Saint-Louis (FR)
- Corresponding author
- Molina, J.-M.
- ORCID
- Molina, J.-M.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-01-01
- Volume
- 167
- Issue
- 1
- Pages
- 217-221
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W1970055029
- Cited by
- 132
- References
- 0
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 1 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 10.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
- Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- intestinal microsporidiosis, Enterocytozoon bieneusi, HIV infection, AIDS, D-xylose absorption, CD4 count, Karnofsky performance status, prevalence
- MeSH terms
- Adult, Animals, Chronic Disease, Diarrhea, Female, Humans, Intestinal Diseases, Parasitic, Male, Middle Aged, Prospective Studies, Prevalence, Microsporida, Microsporidiosis, AIDS-Related Opportunistic Infections
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