The DOI matches its Crossref record, with a small difference in title or year; 14 of the 14 references it cites were found in a registry or an index.
Polymerase Chain Reaction to Detect Cytomegalovirus DNA in the Cerebrospinal Fluid of Neonates with Congenital Infection
Abstract
To determine if cytomegalovirus (CMV) DNA could be detected in the cerebrospinal fluid (CSF) of infants with congenital infection with CMV, polymerase chain reaction (PCR) was done on CSF samples from 13 infants (10 with confirmed, 1 with possible, and 2 with asymptomatic congenital CMV infection) and on CSF samples from 100 control patients with alternative diagnoses. By use of two sets of primers that targeted different areas of the CMV genome, CMV DNA was amplified in the CSF of 6 of 10 symptomatic infants, 0 of 3 infants with asymptomatic CMV infection or possible congenital CMV disease, and 2 control patients (one primer set only). A positive CSF PCR result at birth correlated with a poor neurodevelopmental outcome (P = .048; two-tailed Fisher's exact test).
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“Others have reported the utility of testing for CMV using CSF PCR in cases of suspected congenital infection; however, detection in control patients was also noted (36).”
From Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens (2016) · cites this paper as [36]
Citations
Cites
Infectious Diseases of the Fetus and Newborn Infant
Remington, J. S., & Klein, J. O. (1984) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-198401000-00024 · Cited by 2,470
Symptomatic congenital cytomegalovirus infection: neonatal morbidity and mortality
BOPPANA, S. B., PASS, R. F., BRITT, W. J., STAGNO, S., & ALFORD, C. A. (1992) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199202000-00007 · Cited by 600
Demmler, G. J. (1991) · Clinical Infectious Diseases · doi:10.1093/clinids/13.2.315 · Cited by 486
Self-citationProgressive Hearing Loss in Infants With Asymptomatic Congenital Cytomegalovirus Infection
Williamson, W. D., Demmler, G. J., Percy, A. K., & Catlin, F. I. (1992) · PEDIATRICS · doi:10.1542/peds.90.6.862 · Cited by 271
Self-citationCinque, P. M., Vago, L., Brytting, M., Castagna, A., Accordini, A., Sundqvist, V. A., Zanchetta, N., Monforte, A. D., Wahrén, B., Lazzarin, A., et al. (1992) · The Journal of Infectious Diseases · doi:10.1093/infdis/166.6.1408 · Cited by 133
Wolf, D. G., & Spector, S. A. (1992) · The Journal of Infectious Diseases · doi:10.1093/infdis/166.6.1412 · Cited by 126
Rapid diagnosis of herpes simplex virus encephalitis by using the polymerase chain reaction
Atkins, J. T., Demmler, G. J., & Buffone, G. J. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)81735-4 · Cited by 125
Self-citationGozlan, J., Salord, J. ‐., Roullet, E., et al. (1992) · The Journal of Infectious Diseases · doi:10.1093/infdis/166.6.1416 · Cited by 108
Trang, J. M., Kidd, L. B., Gruber, W. C., Storch, G. A., Demmler, G. J., Jacobs, R., Dankner, W. M., Starr, S. E., Pass, R. F., Stagno, S., et al. (1993) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1993.4 · Cited by 98
Self-citationIdentification of the major capsid protein gene of human cytomegalovirus
Chee, M. S., Rudolph, S. A., Plachter, B., BARRELL, B. G., & Jahn, G. (1989) · Journal of Virology · doi:10.1128/jvi.63.3.1345-1353.1989 · Cited by 72
Cited by
Leber, A. L., Everhart, K., Balada-Llasat, J.-M., Cullison, J., Daly, J., Holt, S., Lephart, P., Salimnia, H., Schreckenberger, P. C., DesJarlais, S., et al. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.00730-16 · Cited by 609
Molecular Methods for Diagnosis of Viral Encephalitis
DeBiasi, R. L., & Tyler, K. L. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.4.903-925.2004 · Cited by 274
Molecular diagnostics in cerebrospinal fluid for the diagnosis of central nervous system infections
Olie, S. E., Andersen, C. Ø., van de Beek, D., & Brouwer, M. C. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00021-24 · Cited by 38
“One study including 10 confirmed cases, based on CMV detection in urine and the presence of neurological symptoms, found a sensitivity of 60% and a specificity of 100% in 100 control patients (212).”
Metadata
- Authors
- Atkins, J. T., Demmler, G. J., Williamson, W. D., McDonald, J. M., Istas, A. S., & Buffone, G. J.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Demmler, G. J.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-06-01
- Volume
- 169
- Issue
- 6
- Pages
- 1334-1337
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2167753862
- Cited by
- 80
- References
- 14
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HO-24064)
- National Center for Research Resources (RR 00188)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
- Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
- Keywords
- cytomegalovirus, congenital cytomegalovirus infection, cerebrospinal fluid, neonates, CMV DNA detection, neurodevelopmental outcomes, prenatal infection
- MeSH terms
- Base Sequence, Cytomegalovirus Infections, Cytomegalovirus, DNA, Viral, Growth Disorders, Humans, Infant, Newborn, Molecular Sequence Data, Nervous System Diseases, Polymerase Chain Reaction
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- CoChat. (2026). Citation check: Polymerase Chain Reaction to Detect Cytomegalovirus DNA in the Cerebrospinal Fluid of Neonates with Congenital Infection. https://app.cochat.ai/papers/10.1093/infdis/169.6.1334
- The paper
- Atkins, J. T., Demmler, G. J., Williamson, W. D., McDonald, J. M., Istas, A. S., & Buffone, G. J. (1994). Polymerase Chain Reaction to Detect Cytomegalovirus DNA in the Cerebrospinal Fluid of Neonates with Congenital Infection. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/169.6.1334
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.