The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
High-Dose Nevirapine: Safety, Pharmacokinetics, And Antiviral Effect In Patients With Human Immunodeficiency Virus Infection
Abstract
Nevirapine, a potent nonnucleoside reverse transcriptase inhibitor, produces a transient antiviral effect at < or = 200 mg/day due to the selection of resistant virus. To examine if higher levels of nevirapine could produce sustained antiviral activity, its safety, pharmacokinetics, and antiviral activity at 400 mg/day were studied in 21 patients. There was a rapid reduction in immune complex-dissociated p24 antigen and serum human immunodeficiency virus RNA concentration in all patients, and 8 of 10 patients had > 50% reduction at 8 weeks. Nevirapine-resistant virus was isolated from all subjects tested at 12 weeks: The mean plasma trough level (4.0 micrograms/mL [15.8 microM]) exceeded the mean IC50 of resistant virus. Rash developed in 48% of patients and was a dose-limiting toxicity factor in 6. These data suggest that clinical testing of potent antiviral compounds that select for drug-resistant virus is justified to determine if serum levels of drug sufficient to overcome resistant virus can be attained.
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Citations
Cites
The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex
Fischl, M. A., Richman, D. D., Grieco, M. H., Gottlieb, M. S., Volberding, P. A., Laskin, O. L., Leedom, J. M., Groopman, J. E., Mildvan, D., Schooley, R. T., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707233170401 · Cited by 2,995
Self-citation
Cited by
Montaner, J. S. G., Reiss, P., Cooper, D., Vella, S., Harris, M., Conway, B., Wainberg, M. A., Smith, D., Robinson, P., Hall, D., et al. (1998) · JAMA · doi:10.1001/jama.279.12.930 · Cited by 756
Self-citationDanner, S. A., Carr, A., Leonard, J. M., Lehman, L. M., Gudiol, F., Gonzales, J., Raventos, A., Rubio, R., Bouza, E., Pintado, V., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199512073332303 · Cited by 567
(2002) · The Lancet · doi:10.1016/s0140-6736(02)08214-4 · Cited by 459
de Béthune, M.-P. (2010) · Antiviral Research · doi:10.1016/j.antiviral.2009.09.008 · Cited by 401
Laurent, C., Kouanfack, C., Koulla-Shiro, S., Nkoué, N., Bourgeois, A., Calmy, A., Lactuock, B., Nzeusseu, V., Mougnutou, R., Peytavin, G., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16586-0 · Cited by 309
Metadata
- Authors
- Havlir, D., Cheeseman, S. H., Mclaughlin, M., Murphy, R., Erice, A., Spector, S. A., Greenough, T. C., Sullivan, J. L., Hall, D., Myers, M., Lamson, M., & Richman, D. D.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-03-01
- Volume
- 171
- Issue
- 3
- Pages
- 537-545
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2163828009
- Cited by
- 298
- References
- 1
- FWCI
- 18.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: High-Dose Nevirapine: Safety, Pharmacokinetics, And Antiviral Effect In Patients With Human Immunodeficiency Virus Infection. https://app.cochat.ai/papers/10.1093/infdis/171.3.537
- The paper
- Havlir, D., Cheeseman, S. H., Mclaughlin, M., Murphy, R., Erice, A., Spector, S. A., Greenough, T. C., Sullivan, J. L., Hall, D., Myers, M., Lamson, M., & Richman, D. D. (1995). High-Dose Nevirapine: Safety, Pharmacokinetics, And Antiviral Effect In Patients With Human Immunodeficiency Virus Infection. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/171.3.537
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
