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Polymerase Chain Reaction and Culture Confirmation of Disseminated Encephalitozoon cuniculi in a Patient with AIDS: Successful Therapy with Albendazole
Abstract
Infections due to microsporidia are being recognized increasingly, especially in AIDS patients. A patient with disseminated microsporidiosis with advanced renal failure due to Encephalitozoon cuniculi (confirmed by culture and polymerase chain reaction [PCR]) is described. The organism from urine and sputum was characterized by culture, Weber's chromotrope-based staining, transmission electron microscopy, and indirect immunofluorescence (IIF) tests. PCR was done on DNA extracted from the infected cell cultures. Treatment with albendazole resulted in improvement in serum creatinine levels, complete disappearance of spores from sputum, a negative urine culture, and a 3-log decline in the number of spores in the urine, as evidenced by chromotrope-based staining. IIF and PCR were used to confirm E. cuniculi as the etiologic agent. Our findings indicate that disseminated microsporidiosis with renal failure in AIDS is treatable.
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Citations
Cited by
Zoonotic Potential of the Microsporidia
Mathis, A., Weber, R., & Deplazes, P. (2005) · Clinical Microbiology Reviews · doi:10.1128/cmr.18.3.423-445.2005 · Cited by 474
Deplazes, P., Mathis, A., Baumgartner, R., Tanner, I., & Weber, R. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.3.557 · Cited by 156
First Cases of Microsporidiosis in Transplant Recipients in Spain and Review of the Literature
Galván, A. L., Martín Sánchez, A. M., Pérez Valentín, M. A., Henriques-Gil, N., Izquierdo, F., Fenoy, S., & del Aguila, C. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.01833-10 · Cited by 113
Microsporidiosis Acquired Through Solid Organ Transplantation: A Public Health Investigation
Hocevar, S. N., Paddock, C. D., Spak, C. W., Rosenblatt, R., Diaz-Luna, H., Castillo, I., Luna, S., Friedman, G. C., Antony, S., Stoddard, R. A., et al. (2014) · Annals of Internal Medicine · doi:10.7326/m13-2226 · Cited by 65
Self-citationAlbendazole Therapy for Microsporidium Diarrhea in Immunocompetent Costa Rican Children
Tremoulet, A. H., Avila-Aguero, M. L., París, M. M., Canas-Coto, A., Ulloa-Gutierrez, R., & Faingezicht, I. (2004) · Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000141724.06556.f9 · Cited by 42
Metadata
- Authors
- De Groote, M. A., Visvesvara, G., Wilson, M. L., Pieniazek, N. J., Slemenda, S. B., daSilva, A. J., Leitch, G. J., Bryan, R. T., & Reves, R.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-05-01
- Volume
- 171
- Issue
- 5
- Pages
- 1375-1378
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W1980022987
- Cited by
- 162
- References
- 0
- FWCI
- 11.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Polymerase Chain Reaction and Culture Confirmation of Disseminated Encephalitozoon cuniculi in a Patient with AIDS: Successful Therapy with Albendazole. https://app.cochat.ai/papers/10.1093/infdis/171.5.1375
- The paper
- De Groote, M. A., Visvesvara, G., Wilson, M. L., Pieniazek, N. J., Slemenda, S. B., daSilva, A. J., Leitch, G. J., Bryan, R. T., & Reves, R. (1995). Polymerase Chain Reaction and Culture Confirmation of Disseminated Encephalitozoon cuniculi in a Patient with AIDS: Successful Therapy with Albendazole. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/171.5.1375
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