The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Perspective: Hypothesis: Serum IgG Antibody Is Sufficient to Confer Protection against Infectious Diseases by Inactivating the Inoculum
Abstract
The theory proposed is that a critical level of specific serum IgG is sufficient to confer protection against infectious diseases by inactivating the inoculum of the pathogen. This theory relies heavily on evaluation of licensed vaccines and includes the following: Measurement of serum antibodies only reliably predicts the efficacy of vaccines, according to regulatory agencies. Serum IgG antibodies alone account for the protection conferred by passive immunization. "Herd" immunity conferred by vaccines on viral and bacterial diseases is best explained by serum antibodies that inactivate the inoculum on mucosal surfaces, thus reducing the pathogen's transmission. Once the disease is manifest, serum antibodies induced by active immunization will neither relieve symptoms nor eliminate the pathogen; specific IgG must be present when the host encounters the pathogen in order to confer protective immunity. Information about the initial pathogen-host contact is vital, whereas knowledge of the symptomatology of the disease may not be essential for vaccine development.
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Cites
Groothuis, J. R., Simoes, E., Levin, M. J., Hall, C. B., Long, C. E., Rodriguez, W. J., Arrobio, J., Meissner, H. C., Fulton, D. R., Welliver, R. C., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311183292102 · Cited by 744
Decline of Childhood Haemophilus influenzae Type b (Hib) Disease in the Hib Vaccine Era
Adams, W. G. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03500020055031 · Cited by 696
Ogra, P. L., Karzon, D. T., Righthand, F., & MacGillivray, M. (1968) · New England Journal of Medicine · doi:10.1056/nejm196810242791701 · Cited by 397
Inactivated and live, attenuated poliovirus vaccines: mucosal immunity.
Sutter, R. W., & Patriarca, P. A. (1993) · Measles and Poliomyelitis · doi:10.1007/978-3-7091-9278-8_23 · Cited by 23 · cited 1×
“nized with an improved formalin-inactivated poliovirus vaccine (EIPV or Salk-type) [135, 136] for -30 years; compliance is almost 100(^.”
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Cited by
Simek, M. D., Rida, W., Priddy, F. H., Pung, P., Carrow, E., Laufer, D. S., Lehrman, J. K., Boaz, M., Tarragona-Fiol, T., Miiro, G., et al. (2009) · Journal of Virology · doi:10.1128/jvi.00110-09 · Cited by 594
Anti-adhesion therapy of bacterial diseases: prospects and problems
Ofek, I., Hasty, D. L., & Sharon, N. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(03)00228-1 · Cited by 444
Piechotta, V., Chai, K. L., Valk, S. J., Doree, C., Monsef, I., Wood, E. M., Lamikanra, A., Kimber, C., McQuilten, Z., So-Osman, C., et al. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013600.pub2 · Cited by 367
Estimating the protective concentration of anti-pneumococcal capsular polysaccharide antibodies
Siber, G. R., Chang, I., Baker, S., Fernsten, P., O’Brien, K. L., Santosham, M., Klugman, K. P., Madhi, S. A., Paradiso, P., & Kohberger, R. (2007) · Vaccine · doi:10.1016/j.vaccine.2007.01.119 · Cited by 366
Herremans, T. M. P. T., Reimerink, J. H. J., Buisman, A. M., Kimman, T. G., & Koopmans, M. P. G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.8.5011 · Cited by 149
Metadata
- Authors
- Robbins, J. B., Schneerson, R., & Szu, S. C.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-06-01
- Volume
- 171
- Issue
- 6
- Pages
- 1387-1398
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2116058470
- Cited by
- 385
- References
- 4
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Perspective: Hypothesis: Serum IgG Antibody Is Sufficient to Confer Protection against Infectious Diseases by Inactivating the Inoculum. https://app.cochat.ai/papers/10.1093/infdis/171.6.1387
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- Robbins, J. B., Schneerson, R., & Szu, S. C. (1995). Perspective: Hypothesis: Serum IgG Antibody Is Sufficient to Confer Protection against Infectious Diseases by Inactivating the Inoculum. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/171.6.1387
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
