The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Abrupt Emergence of a Single Dominant Multidrug-Resistant Strain of Escherichia coli
Open accessAbstract
BACKGROUND: Fluoroquinolone-resistant Escherichia coli are increasingly prevalent. Their clonal origins--potentially critical for control efforts--remain undefined. METHODS: Antimicrobial resistance profiles and fine clonal structure were determined for 236 diverse-source historical (1967-2009) E. coli isolates representing sequence type ST131 and 853 recent (2010-2011) consecutive E. coli isolates from 5 clinical laboratories in Seattle, Washington, and Minneapolis, Minnesota. Clonal structure was resolved based on fimH sequence (fimbrial adhesin gene: H subclone assignments), multilocus sequence typing, gyrA and parC sequence (fluoroquinolone resistance-determining loci), and pulsed-field gel electrophoresis. RESULTS: Of the recent fluoroquinolone-resistant clinical isolates, 52% represented a single ST131 subclonal lineage, H30, which expanded abruptly after 2000. This subclone had a unique and conserved gyrA/parC allele combination, supporting its tight clonality. Unlike other ST131 subclones, H30 was significantly associated with fluoroquinolone resistance and was the most prevalent subclone among current E. coli clinical isolates, overall (10.4%) and within every resistance category (11%-52%). CONCLUSIONS: Most current fluoroquinolone-resistant E. coli clinical isolates, and the largest share of multidrug-resistant isolates, represent a highly clonal subgroup that likely originated from a single rapidly expanded and disseminated ST131 strain. Focused attention to this strain will be required to control the fluoroquinolone and multidrug-resistant E. coli epidemic.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gupta, K., Hooton, T. M., Naber, K. G., Wullt, B., Colgan, R., Miller, L. G., Moran, G. J., Nicolle, L. E., Raz, R., Schaeffer, A. J., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/ciq257 · Cited by 3,038
Peirano, G., & Pitout, J. D. D. (2010) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2009.11.003 · Cited by 443
Cited by
Pandemic lineages of extraintestinal pathogenic Escherichia coli
Riley, L. W. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12646 · Cited by 412
Nesta, B., Valeri, M., Spagnuolo, A., Rosini, R., Mora, M., Donato, P., Alteri, C. J., Del Vecchio, M., Buccato, S., Pezzicoli, A., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004124 · Cited by 68
Metadata
- Authors
- Johnson, J. R., Tchesnokova, V., Johnston, B., Clabots, C., Roberts, P. L., Billig, M., Riddell, K., Rogers, P., Qin, X., Butler-Wu, S., Price, L. B., Aziz, M., Nicolas-Chanoine, M.-H., DebRoy, C., Robicsek, A., Hansen, G., Urban, C., Platell, J., Trott, D. J., Zhanel, G., Weissman, S. J., Cookson, B. T., Fang, F. C., Limaye, A. P., Scholes, D., Chattopadhyay, S., Hooper, D. C., & Sokurenko, E. V.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-01-03
- Volume
- 207
- Issue
- 6
- Pages
- 919-928
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2139852129
- Cited by
- 269
- References
- 2
- FWCI
- 15.49
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Abrupt Emergence of a Single Dominant Multidrug-Resistant Strain of Escherichia coli. https://app.cochat.ai/papers/10.1093/infdis/jis933
- The paper
- Johnson, J. R., Tchesnokova, V., Johnston, B., Clabots, C., Roberts, P. L., Billig, M., Riddell, K., Rogers, P., Qin, X., Butler-Wu, S., Price, L. B., Aziz, M., Nicolas-Chanoine, M.-H., DebRoy, C., Robicsek, A., Hansen, G., Urban, C., Platell, J., Trott, D. J., . . . Sokurenko, E. V. (2013). Abrupt Emergence of a Single Dominant Multidrug-Resistant Strain of Escherichia coli. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jis933
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
