Differences in the nasopharyngeal microbiome during acute respiratory tract infection with human rhinovirus and respiratory syncytial virus in infancy
Open accessAbstract
Respiratory viruses alter the nasopharyngeal microbiome and may be associated with a distinct microbial signature. To test this hypothesis, we compared the nasopharyngeal microbiome of 135 previously healthy infants with acute respiratory infection due to human rhinovirus (HRV; n = 52) or respiratory syncytial virus (RSV; n = 83). The nasopharyngeal microbiome was assessed by sequencing the V4 region of the 16S ribosomal RNA. Respiratory viruses were identified by quantitative reverse-transcription polymerase chain reaction. We found significant differences in the overall taxonomic composition and abundance of certain bacterial genera between infants infected with HRV and those infected with RSV. Our results suggest that respiratory tract viral infections are associated with different nasopharyngeal microbial profiles.
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A 16s rRNA sequencing-based study conducted in infants with acute RSV or hRV respiratory infections reported that infants with RSV had significantly higher abundance of Staphylococcus spp. compared to hRV-infected infants.
“A 16s rRNA sequencing-based study conducted in infants with acute RSV or hRV respiratory infections reported that infants with RSV had significantly higher abundance of Staphylococcus spp. compared to hRV-infected infants (113).”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [113]
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References 15 · Cited by 102
- Authors
- Rosas-Salazar, C., Shilts, M. H., Tovchigrechko, A., Schobel, S., Chappell, J. D., Larkin, E. K., Shankar, J., Yooseph, S., Nelson, K. E., Halpin, R. A., Moore, M. L., Anderson, L. J., Peebles, R. S., Das, S. R., & Hartert, T. V.
- Affiliations
- Vanderbilt University (US)
- J. Craig Venter Institute (US)
- Emory University (US)
- Corresponding author
- Das, Suman R.
- ORCID
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-12-05
- Volume
- 214
- Issue
- 12
- Pages
- 1924-1928
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC5142087
- OpenAlex
- W2559974100
- Cited by
- 102
- References
- 15
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 9 · 2023: 8 · 2022: 16 · 2021: 21 · 2020: 14 · 2019: 8 · 2018: 11 · 2017: 7
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health
- NIH (U19 AI095227, K24 AI77930, U19 AI110819, UL1 TR000445, U54 RR24975, HHSN272200900007C)
- National Institute of Allergy and Infectious Diseases
- Institute Genomic Centers for Infectious Diseases Program
- Topics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- nasopharyngeal microbiota, human rhinovirus, respiratory syncytial virus, acute respiratory infections, infants, viral infection, bacterial taxa, microbial signatures
- MeSH terms
- Bacteria, DNA, Ribosomal, Female, Humans, Infant, Male, Nasopharynx, Picornaviridae Infections, Prospective Studies, Respiratory Tract Infections, RNA, Ribosomal, 16S, Sequence Analysis, DNA, Respiratory Syncytial Virus Infections, Microbiota
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