Urban Slums: A Supportive Ecosystem for Typhoidal Salmonellae
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The typhoidal Salmonellae were controlled in cities in North America and Europe in the late 19th and early 20th century by development of centralized water treatment systems. In the early 21st century, large urban centers where drinking water routinely mixes with human feces have the highest burden of typhoid fever. Although improving municipal drinking water quality is the most robust approach to reduce enteric fever burden, the high costs and managerial capacity that such systems require and decreasing per capita water availability requires new approaches to reach the highest risk communities. The spread of antimicrobial resistance threatens to increase the burden of enteric fever much sooner than the extension of safe reliable water service delivery can be implemented. Thus, vaccination is an important interim measure.
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Rising bacterial resistance among bloodstream and typhoid infections has been documented in some LMICs and is typically associated with poorer clinical outcomes, though few data specific to urban informal settlements are available.
“Rising bacterial resistance among bloodstream 72-74 and typhoid 75 infections has been documented in some LMICs and is typically associated with poorer clinical outcomes, 76 though few data specific to urban informal settlements are available.”
From Urban informal settlements as hotspots of antimicrobial resistance and the need to curb environmental transmission. (2020) · cites this paper as [75]
There are significant challenges to improving water and sanitation infrastructure in urban informal settlements.
“There are undoubtedly significant challenges to improving water and sanitation infrastructure in urban informal settlements 34,75 .”
From Urban informal settlements as hotspots of antimicrobial resistance and the need to curb environmental transmission. (2020) · cites this paper as [75]
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Nadimpalli, M. L., Marks, S. J., Montealegre, M. C., Gilman, R. H., Pajuelo, M. J., Saito, M., Tsukayama, P., Njenga, S. M., Kiiru, J., Swarthout, J., et al. (2020) · Nature microbiology · doi:10.1038/s41564-020-0722-0 · Cited by 223 · see citing works
- Authors
- Luby, S. P.
- Affiliations
- Stanford University (US)
- Corresponding author
- Luby, Stephen P
- ORCID
- Luby, Stephen P
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-07-27
- Volume
- 218
- Issue
- suppl_4
- Pages
- S250-S254
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC6226803
- OpenAlex
- W2883157470
- Cited by
- 25
- References
- 2
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 2
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Infectious Diseases (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Stanford’s Woods Institute for the Environment
- Stanford’s Center for Innovation in Global Health
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Social Sciences › Urban Studies › Urban and Rural Development Challenges
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Public Health and Environmental Issues
- Keywords
- typhoidal Salmonella, typhoid fever, enteric fever, urban slums, fecal-oral transmission, drinking water quality, water treatment, antimicrobial resistance, typhoid vaccination, high-risk communities, water scarcity
- MeSH terms
- Government, Humans, International Agencies, Poverty Areas, Salmonella, Typhoid Fever, Urban Population, Water Microbiology, Water Supply, Ecosystem, Water Quality, Drinking Water
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