The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases
Abstract
Using the suppression subtractive hybridization technique, we isolated a novel kinase, IKK-i, whose message is drastically induced by lipopolysaccharide (LPS) in the mouse macrophage cell line RAW264. 7. The predicted protein contains the kinase domain in its N-terminus, which shares 30% identity to that of IKK-alpha or IKK-beta. The C-terminal portion contains a leucine zipper and a potential helix-loop-helix domain, as in the case of IKK-alpha and IKK-beta. IKK-i is expressed mainly in immune cells, and is induced in response to proinflammatory cytokines such as tumor necrosis factor-alpha, IL-1 and IL-6, in addition to LPS. Overexpression of wild-type IKK-i phosphorylated serine residues Ser32 and Ser36 of IkappaB-alpha (preferentially Ser36), and significantly stimulated NF-kappaB activation. These results suggest that IKK-i is an inducible IkappaB kinase which may play a special role in the immune response.
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A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
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IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
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Cited by
NF-κB: a key role in inflammatory diseases
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Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,235
Self-citationIKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,676
Signaling to NF-κB by Toll-like receptors
Kawai, T., & Akira, S. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.09.002 · Cited by 2,388
Self-citationLPS induction of gene expression in human monocytes
Guha, M., & Mackman, N. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(00)00149-2 · Cited by 2,304
Metadata
- Authors
- Shimada, T., Kawai, T., Takeda, K., Matsumoto, M., Inoue, J.-I., Tatsumi, Y., Kanamaru, A., & Akira, S.
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08
- Volume
- 11
- Issue
- 8
- Pages
- 1357-1362
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2148927360
- Cited by
- 369
- References
- 24
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shimada, T., Kawai, T., Takeda, K., Matsumoto, M., Inoue, J.-I., Tatsumi, Y., Kanamaru, A., & Akira, S. (1999). IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases. International Immunology. https://doi.org/10.1093/intimm/11.8.1357
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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