The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Zinc suppresses Th17 development via inhibition of STAT3 activation
Abstract
Zinc (Zn) is an essential trace metal required by many enzymes and transcription factors for their activity or the maintenance of their structure. Zn has a variety of effects in the immune responses and inflammation, although it has not been well known how Zn affects these reactions on the molecular basis. We here showed that Zn suppresses T(h)17-mediated autoimmune diseases at lest in part by inhibiting the development of T(h)17 cells via attenuating STAT3 activation. In mice injected with type II collagen to induce arthritis, Zn treatment inhibited T(h)17 cell development. IL-6-mediated activation of STAT3 and in vitro T(h)17 cell development were all suppressed by Zn. Importantly, Zn binding changed the alpha-helical secondary structure of STAT3, disrupting the association of STAT3 with JAK2 kinase and with a phospho-peptide that included a STAT3-binding motif from the IL-6 signal transducer gp130. Thus, we conclude that Zn suppresses STAT3 activation, which is a critical step for T(h)17 development.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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Self-citationZinc transporter ZIP8 (SLC39A8) and zinc influence IFN-γ expression in activated human T cells
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Gombart, A. F., Pierre, A., & Maggini, S. (2020) · Nutrients · doi:10.3390/nu12010236 · Cited by 1,358
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The role of zinc, copper, manganese and iron in neurodegenerative diseases
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Metadata
- Authors
- Kitabayashi, C., Fukada, T., Kanamoto, M., Ohashi, W., Hojyo, S., Atsumi, T., Ueda, N., Azuma, I., Hirota, H., Murakami, M., & Hirano, T.
- Venue
- International Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-03-09
- Volume
- 22
- Issue
- 5
- Pages
- 375-386
- ISSN
- 0953-8178 (ISSN-L)
- 1460-2377
- OpenAlex
- W2103254653
- Cited by
- 175
- References
- 9
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kitabayashi, C., Fukada, T., Kanamoto, M., Ohashi, W., Hojyo, S., Atsumi, T., Ueda, N., Azuma, I., Hirota, H., Murakami, M., & Hirano, T. (2010). Zinc suppresses Th17 development via inhibition of STAT3 activation. International Immunology. https://doi.org/10.1093/intimm/dxq017
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