The DOI matches its Crossref record.
Herpes simplex virus infections of the eye and their management with acyclovir
Abstract
Herpetic keratitis remains a prominent cause of recurrent or chronic and blinding corneal disease; areas of particular difficulty are indolent ulceration, herpetic keratouveitis, keratoplasty and problems associated with steroid therapy. Topical acyclovir has been widely demonstrated to be a safe and effective antiviral for ulcerative herpetic keratitis; furthermore its particular advantages of high efficacy, minimal toxicity and good ocular penetration, suggest that it should be the treatment of choice for patients within these other areas of particular difficulty.
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“Acyclovir (ACV), a synthetic nucleoside analogue, has been extensively used as a safe and effective antiviral agent for ulcerative herpetic keratitis [144].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [144]
Citations
Cited by
Clinical Manifestations and Treatment Considerations of Herpes Simplex Virus Infection
Simmons, A. (2002) · The Journal of Infectious Diseases · doi:10.1086/342967 · Cited by 137
“Although originally developed as an ophthalmic ointment formulation outside the United States, subsequent studies with oral acyclovir showed good intraocular and tissue penetration [27, 28].”
BackgroundOcular Sustained Release Nanoparticles Containing Stereoisomeric Dipeptide Prodrugs of Acyclovir
Jwala, J., Boddu, S. H. S., Shah, S. J., Sirimulla, S., Pal, D., & Mitra, A. K. (2011) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2010.0188 · Cited by 40
“Topical treatment of ACV in the form of ointment has been proved to be effective in the treatment of superficial HSV keratitis.(7) However, its use in the United States has not been approved by the Food and Drug Administration (FDA) due to side effects associated with this formulation; and the treatment fails especial…”
BackgroundHelicase‐Primase as a Target of New Therapies for Herpes Simplex Virus Infections
James, S., Kb, L., Acosta, E., & Prichard, M. N. (2014) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3 · Cited by 30
“ACV is highly effective in the treatment of HK and can also be used at a suppressive dose to reduce the number of HK recurrences, both of which are crucial for preventing corneal scarring and vision loss.(16) Left untreated, HSE results in up to 70% mortality and nearly all survivors exhibit impaired neurologic outcom…”
BackgroundBranco, B. C. (2004) · British Journal of Ophthalmology · doi:10.1136/bjo.2003.040162 · Cited by 27
Streissle, G., Paessens, A., & Oediger, H. (1985) · Advances in virus research · doi:10.1016/s0065-3527(08)60449-2 · Cited by 20
The Effect of Acyclovir on the Acute and Latent Murine Gammaherpesvirus-68 Infection of Mice
Sunil-Chandra, N. P., Efstathiou, S., & Nash, A. A. (1994) · Antiviral chemistry & chemotherapy · doi:10.1177/095632029400500502 · Cited by 14
The need for new antiviral agents
Freestone, D. S. (1985) · Antiviral Research · doi:10.1016/0166-3542(85)90001-4 · Cited by 14
A Possible Pitfall in Acyclovir Prophylaxis for Recurrent Herpetic Keratitis?
James, S. H., & Prichard, M. N. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit379 · Cited by 12
From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics
Sun, M., Wang, J., Fan, W., Wang, K., Wang, Y., Zhang, J., Ding, S., Zhang, C., Feng, Z., Wang, Y.-G., et al. (2025) · Materials today. Bio · doi:10.1016/j.mtbio.2025.102537 · Cited by 7
“Acyclovir (ACV), a synthetic nucleoside analogue, has been extensively used as a safe and effective antiviral agent for ulcerative herpetic keratitis [144].”
Chemotherapy of herpesvirus infections: Present successes and future hopes
Crowe, S. M., & MILLS, J. S. (1985) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf02014424 · Cited by 3
Recent Advances in Antiherpetic Drugs
Flowers, F. P., Araujo, O. E., & Turner, L. A. (1988) · International Journal of Dermatology · doi:10.1111/j.1365-4362.1988.tb02417.x · Cited by 3
Colin, J., Mazet, D., & Chastel, C. (1985) · Documenta ophthalmologica. Proceedings series · doi:10.1007/978-94-009-5518-9_32 · Cited by 2
A Review of Acyclovir in the Management of Herpes Simplex Virus Infections of the Eye
Rees, P. J. (1985) · Documenta ophthalmologica. Proceedings series · doi:10.1007/978-94-009-5518-9_28 · Cited by 1
Metadata
- Authors
- Falcon, M. G.
- Affiliations
- St Thomas' Hospital (GB)
- Corresponding author
- Falcon, M. G.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-01-01
- Volume
- 12
- Issue
- suppl B
- Pages
- 39-43
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2138781485
- Cited by
- 13
- References
- 0
- Citations by year
- 2025: 1 · 2014: 1 · 2013: 1
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Antimicrobial Chemotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Ophthalmology › Corneal surgery and disorders
- Keywords
- herpes simplex virus, herpes simplex keratitis, acyclovir, topical antiviral therapy, corneal transplantation, corticosteroid therapy, ocular penetration, corneal ulcer, ocular herpes
- MeSH terms
- Acyclovir, Administration, Topical, Clinical Trials as Topic, Humans, Keratitis, Dendritic
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