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Inhibitor-resistant TEM -lactamases: phenotypic, genetic and biochemical characteristics
Abstract
Beta-lactamases represent the main mechanism of bacterial resistance to beta-lactam antibiotics. The recent emergence of bacterial strains producing inhibitor-resistant TEM (IRT) enzymes could be related to the frequent use of beta-lactamase inhibitors such as clavulanic acid, sulbactam and tazobactam in hospitals and in general practice. The IRT beta-lactamases differ from the parental enzymes TEM-1 or TEM-2 by one, two or three amino acid substitutions at different locations. This paper reviews the phenotypic, genetic and biochemical characteristics of IRT beta-lactamases in an attempt to shed light on the pressures that have contributed to their emergence.
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Citations
Cited by
Three Decades of β-Lactamase Inhibitors
Drawz, S. M., & Bonomo, R. A. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00037-09 · Cited by 1,709
Growing Group of Extended-Spectrum β-Lactamases: the CTX-M Enzymes
Bonnet, R. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.1.1-14.2004 · Cited by 1,494
Synergism between natural products and antibiotics against infectious diseases
Hemaiswarya, S., Kruthiventi, A. K., & Doble, M. (2008) · Phytomedicine · doi:10.1016/j.phymed.2008.06.008 · Cited by 916
Bacterial Resistance to β-Lactam Antibiotics: Compelling Opportunism, Compelling Opportunity
Fisher, J. F., Meroueh, S. O., & Mobashery, S. (2005) · Chemical Reviews · doi:10.1021/cr030102i · Cited by 913
Tamma, P. D., Aitken, S. L., Bonomo, R. A., Mathers, A. J., van Duin, D., & Clancy, C. J. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad428 · Cited by 740
Metadata
- Authors
- Chaibi, E. B., Sirot, D., Paul, G., & Labia, R.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-04-01
- Volume
- 43
- Issue
- 4
- Pages
- 447-458
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2163823303
- Cited by
- 256
- References
- 0
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chaibi, E. B., Sirot, D., Paul, G., & Labia, R. (1999). Inhibitor-resistant TEM -lactamases: phenotypic, genetic and biochemical characteristics. Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/43.4.447
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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