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Spondylodiscitis: update on diagnosis and management
Abstract
Spondylodiscitis, a term encompassing vertebral osteomyelitis, spondylitis and discitis, is the main manifestation of haematogenous osteomyelitis in patients aged over 50 years. Staphylococcus aureus is the predominant pathogen, accounting for about half of non-tuberculous cases. Diagnosis is difficult and often delayed or missed due to the rarity of the disease and the high frequency of low back pain in the general population. In this review of the published literature, we found no randomized trials on treatment and studies were too heterogeneous to allow comparison. Improvements in surgical and radiological techniques and the discovery of antimicrobial therapy have transformed the outlook for patients with this condition, but morbidity remains significant. Randomized trials are needed to assess optimal treatment duration, route of administration, and the role of combination therapy and newer agents.
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Pappas, P. G., Kauffman, C. A., Andes, D., Benjamin, D. K., Calandra, T. F., Edwards, J. E., Filler, S. G., Fisher, J. F., Kullberg, B.-J., Zeichner, L. O., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/596757 · Cited by 3,191
Rybak, M., Lomaestro, B., Rotschafer, J. C., Moellering, R., Craig, W., Billeter, M., Dalovisio, J. R., & Levine, D. P. (2009) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp080434 · Cited by 1,795
Cited by
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Finucane, L. M., Downie, A., Mercer, C., Greenhalgh, S. M., Boissonnault, W. G., Pool-Goudzwaard, A. L., Beneciuk, J. M., Leech, R. L., & Selfe, J. (2020) · Journal of Orthopaedic & Sports Physical Therapy · doi:10.2519/jospt.2020.9971 · Cited by 287
Metadata
- Authors
- Gouliouris, T., Aliyu, S. H., & Brown, N. M.
- Venue
- Journal of Antimicrobial Chemotherapy
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09-28
- Volume
- 65
- Issue
- Supplement 3
- Pages
- iii11-iii24
- ISSN
- 0305-7453 (ISSN-L)
- 1460-2091
- OpenAlex
- W2166176915
- Cited by
- 780
- References
- 2
- FWCI
- 26.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gouliouris, T., Aliyu, S. H., & Brown, N. M. (2010). Spondylodiscitis: update on diagnosis and management. Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/dkq303
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
