Time-kill kinetics of anti-tuberculosis drugs, and emergence of resistance, in relation to metabolic activity of Mycobacterium tuberculosis

de Steenwinkel, J. E. M.; de Knegt, G. J.; ten Kate, M. T.; van Belkum, A.; Verbrugh, H. A.; Kremer, K.; van Soolingen, D.; Bakker-Woudenberg, I. A. J. M.

doi:10.1093/jac/dkq374

Time-kill kinetics of anti-tuberculosis drugs, and emergence of resistance, in relation to metabolic activity of Mycobacterium tuberculosis

Objectives The pharmacodynamics of tuberculosis (TB) treatment should be further explored, to prevent emergence of resistance, treatment failure and relapse of infection. The diagnostic drug susceptibility tests guiding TB therapy investigate metabolically active Mycobacterium tuberculosis (Mtb) …