The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
CHOP is a multifunctional transcription factor in the ER stress response
Abstract
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) induces ER stress. To restore ER homeostasis, cells possess a highly specific ER quality-control system called the unfold protein response (UPR). In the case of prolonged ER stress or UPR malfunction, apoptosis signalling is activated. This ER stress-induced apoptosis has been implicated in the pathogenesis of several conformational diseases. CCAAT-enhancer-binding protein homologous protein (CHOP) is induced by ER stress and mediates apoptosis. Recent studies by the Gotoh group have shown that the CHOP pathway is also involved in ER stress-induced cytokine production in macrophages. The multifunctional roles of CHOP in the ER stress response are discussed below.
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Cites
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Cited by
Decoding cell death signals in liver inflammation
Brenner, C., Galluzzi, L., Kepp, O., & Kroemer, G. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.033 · Cited by 1,022
Shi, C.-S., Nabar, N. R., Huang, N.-N., & Kehrl, J. H. (2019) · Cell Death Discovery · doi:10.1038/s41420-019-0181-7 · Cited by 404
McSweeney, K. R., Gadanec, L. K., Qaradakhi, T., Ali, B. A., Zulli, A., & Apostolopoulos, V. (2021) · Cancers · doi:10.3390/cancers13071572 · Cited by 363
Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy
Schönthal, A. H. (2012) · Scientifica · doi:10.6064/2012/857516 · Cited by 353
Piao, M. J., Ahn, M. J., Kang, K. A., Ryu, Y. S., Hyun, Y. J., Shilnikova, K., Zhen, A. X., Jeong, J. W., Choi, Y. H., Kang, H. K., et al. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2197-9 · Cited by 339
“ER stress promotes the expression of C/EBP homologous protein (CHOP), which mediates apoptosis (Nishitoh 2012), and of the ER chaperone and signaling regulator GRP78, which activates protein kinase R-like ER kinase (PERK) through phosphorylation.”
Metadata
- Authors
- Nishitoh, H.
- Venue
- Journal of Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-12-30
- Volume
- 151
- Issue
- 3
- Pages
- 217-219
- ISSN
- 0021-924X (ISSN-L)
- OpenAlex
- W2113254662
- Cited by
- 469
- References
- 20
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- closed
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