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Cited by 162Food Allergy and Anaphylaxis ResearchDrug-Induced Adverse ReactionsEosinophilic Esophagitis

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Soy Protein Allergy: Incidence and Relative Severity

Open access
Cordle, Christopher T.·2004·The Journal of Nutrition
DOI 10.1093/jn/134.5.1213s
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Abstract

Food allergy is a relatively rare and sometimes violent reaction of the immune system to food proteins. The first report characterizing soy allergy appeared in 1934. The Food and Agriculture Organization of the United Nations includes soy in its list of the 8 most significant food allergens. At least 16 potential soy protein allergens have been identified but their relative clinical significance is unknown. Conversely, soy has a long history of successful use in managing cow's milk allergies in infants. To better predict the utility of soy proteins for controlling food allergy, it is important to understand the relative allergenic reactivity of soy compared with other major food proteins. This can be studied using clinical data, animal models, and biochemical approaches; all show diminished reactivity for soy. Clinical studies using in vitro methods and blinded food challenges have generated substantial information. Study populations include high-risk asymptomatic infants and patients with atopic symptoms, positive food challenges, and specific milk allergies. Generally, these studies show lower allergic reactivity for soy proteins vs. other food allergens. Comparisons of food allergen dose-response relationships for triggering allergic symptoms also demonstrate a higher protein concentration threshold for soy (approximately 100 times), indicating lower allergenic reactivity. Extensive investigations of soy immunological reactivity have also been carried out using animal models. Consistent with clinical results, all of these data show substantially diminished immunological reactivity for soy proteins. Biochemical and immunochemical analyses indicate no striking differences between soy and other food proteins that would explain these unexpected differences in allergenic reactivity.

Overview

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Crossref · 10.1093/jn/134.5.1213s

Cites

44 of 44 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 3

  1. Businco, 1987, Prevention of atopy: results of long-term (7 months to 8 years) follow-up, Ann. Allergy, 59, 361
  2. Devey, 1976, The modified anaphylaxis hypothesis for cot death, Clin. Exp. Immunol, 26, 542
  3. Duska-McEwen, 1999, Predicting Allergenic Reactivity of Elemental Nutritionals, J. Allergy Clin. Immunol, 103, S68

Cited by

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Metadata

Authors
Cordle, C. T.
Affiliations
Abbott (United States) (US)
Corresponding author
Cordle, Christopher T.
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2004-05
Volume
134
Issue
5
Pages
1213S-1219S
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/134.5.1213s
OpenAlex
W1916093544
Cited by
162
References
44
Citations by year
2026: 9 · 2025: 8 · 2024: 10 · 2023: 7 · 2022: 7 · 2021: 3 · 2020: 12 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 4 · 2014: 9 · 2013: 7 · 2012: 7
FWCI
0.60
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
  • Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
  • Health Sciences › Medicine › Gastroenterology › Eosinophilic Esophagitis
Keywords
food allergy, soy allergens, allergenicity, cow's milk allergy, infant feeding, dose-response relationship, atopic symptoms
MeSH terms
Allergens, Animals, Food Hypersensitivity, Humans, Osmolar Concentration, Severity of Illness Index, Incidence, Milk Hypersensitivity, Soybean Proteins

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.