The DOI matches its Crossref record; 57 of the 58 references it cites were found in a registry or an index.
Exercise, Serum Free Tryptophan, and Central Fatigue
Open accessAbstract
Brain tryptophan (TRP) concentrations and serotonin (5HT) synthesis and release increase during running. This increase in 5HT function may promote central fatigue and contribute to suboptimal physical performance. The rise in brain TRP is reputed to result from exercise-induced elevations in serum nonesterified fatty acid (NEFA) concentrations, which dissociate TRP from albumin in blood and increase the serum free TRP pool. But, as discussed in this article, ample evidence exists that the serum free TRP pool does not control brain TRP uptake. The clearest data are dietary, but pharmacologic data in exercising rats also support this conclusion. Changes in the serum levels of amino acids that compete with TRP for brain uptake appear also not to explain the rise in brain TRP. The mechanism is therefore not presently known. The link between the rise in brain TRP and 5HT synthesis/release is not simple: a rise in brain TRP stimulates 5HT synthesis/release in actively firing neurons. Hence, during exercise, only 5HT neurons that are firing should increase 5HT production/release when brain TRP rises. It is not known which 5HT neurons fire during exercise; the 5HT neurons that respond to exercise-induced increases in brain TRP are therefore not known. Hence, it is not possible to conclude which 5HT neurons contribute to the generation of central fatigue. Because some 5HT neurons control specific functions important to physical performance (e.g., respiration), the current understanding of 5HT neuronal function in central fatigue might benefit from the study of specific 5HT pathways during exercise.
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“Large doses of simple antioxidant mixtures or individual vitamins are not recommended and may be toxic. Athletes should obtain antioxidants from an increased consumption of fruits and vegetables [95].”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [95]
Citations
Cites
Spinal and Supraspinal Factors in Human Muscle Fatigue
Gandevia, S. C. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.4.1725 · Cited by 3,855
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
Oldendorf, W. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.221.6.1629 · Cited by 1,691
Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels
Fernstrom, J. D., & Wurtman, R. J. (1971) · Science · doi:10.1126/science.173.3992.149 · Cited by 1,017
Self-citationPUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
Tunaru, S., Kero, J. T., Schaub, A., Wufka, C., Blaukat, A., Pfeffer, K., & Offermanns, S. (2003) · Nature Medicine · doi:10.1038/nm824 · Cited by 801
Brain Serotonin Content: Increase Following Ingestion of Carbohydrate Diet
Fernstrom, J. D., & Wurtman, R. J. (1971) · Science · doi:10.1126/science.174.4013.1023 · Cited by 734
Self-citationPossible mechanisms of central nervous system fatigue during exercise
Davis, J. M., & Bailey, S. P. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199701000-00008 · Cited by 686
Supraspinal factors in human muscle fatigue: evidence for suboptimal output from the motor cortex.
Gandevia, S. C., Allen, G. M., Butler, J. E., & Taylor, J. L. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021164 · Cited by 681
The Specific Binding of l-Tryptophan to Serum Albumin
McMenamy, R. H., & Oncley, J. L. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)49353-2 · Cited by 640
Anatomy of the Serotonergic Systema
Törk, I. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb16870.x · Cited by 557
Serotonergic neurons as carbon dioxide sensors that maintain ph homeostasis
Richerson, G. B. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1409 · Cited by 519
Research works printed but not linked: 2
- Tagliamonte, 1971, Possible role of “free” plasma tryptophan in controlling brain tryptophan concentrations, Riv Farmacol Ter., 2, 251
- Martin, 1999, Relationship between medullary serotonergic neuronal activity and diminished motor capacity in awake cats, Soc Neurosci Abstr., 25, 175
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Zhang, Y., Tang, T. Y., Pavalagantharajah, S., Gobran, C. N., Khawaja, Z., Chen, A. J., & Singh, G. (2016) · Springer eBooks · doi:10.1007/978-3-319-28558-0_8
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Koinis, F., & Gioulbasanis, I. (2015) · Springer eBooks · doi:10.1007/978-3-319-21683-6_38
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Tsuda, Y., Tagawa, R., Ueda, K., & Sanbongi, C. (2022) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.11.67
Алексеевич, М. В., Андреевич, Г. М., Владимирович, К. А., & Kostrov, S. А. (2024) · Patient-Oriented Medicine and Pharmacy · doi:10.37489/2949-1924-0040
Adams, N. N. (2025) · International Journal of Risk & Safety in Medicine · doi:10.1177/09246479251346445
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Gandhi, J. D. (2010) · University Library - University of Saskatchewan (University of Saskatchewan)
Sánchez‐Chapul, L., Ortega, D. R., Samudio-Cruz, M. A., Cabrera-Ruiz, E., Luna‐Angulo, A. B., de la Cruz, G. P., Valencia-León, J. F., Carrillo‐Mora, P., Landa‐Solís, C., Rangel‐López, E., et al. (2026) · Nutrients · doi:10.3390/nu18020211
Zhang, X., Lin, L., Wang, H., & Dai, M. (2026) · Frontiers in Psychology · doi:10.3389/fpsyg.2026.1710518
Ostapiuk–Karolczuk, J., Kasperska, A., Dziewiecka, H., Cichoń-Woźniak, J., Gruszka, W., Basta, P., Kaczmarczyk, S., Reysner, M., & Skarpańska-Stejnborn, A. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1845286
Nutritional strategies to reduce fatigue-related occupational accidents among construction workers
Kolahdouzipour, F., Al-Zharani, M., Nasr, F. A., Alneghery, L. M., Alzahrani, N. S., Khalili, L., Barasarathi, J., & Sayyed, R. Z. (2026) · International Journal of Occupational Safety and Ergonomics · doi:10.1080/10803548.2026.2716446
Metadata
- Authors
- Fernstrom, J. D., & Fernstrom, M. H.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Fernstrom, John D
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 136
- Issue
- 2
- Pages
- 553S-559S
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W1933839043
- Cited by
- 117
- References
- 58
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 8 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 9 · 2015: 3 · 2014: 7 · 2013: 4 · 2012: 11
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- central fatigue, brain tryptophan, serotonin synthesis, serotonin release, physical activity, free fatty acids, amino acid competition, serotonergic neurons, physical performance, running
- MeSH terms
- Animals, Brain, Fatigue, Fatty Acids, Nonesterified, Neurons, Niacin, Physical Conditioning, Animal, Serotonin, Tryptophan, Rats
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