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Cited by 186Iron Metabolism and DisordersTrace Elements in HealthIron and Steelmaking Processes

Host-Pathogen Interactions: The Role of Iron1,

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Doherty, Conor P.·2007·The Journal of Nutrition
DOI 10.1093/jn/137.5.1341
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Abstract

Iron is essential for both host and pathogen, and complex systems of acquisition and utilization have evolved in competition. Our increasing knowledge of the basic mechanisms of homeostasis and their adaptation during deficiency, overload, and infection indicate that iron is a key regulator of host pathogen interactions. This review concentrated on the clinical and public health aspects of the interaction between the iron acquisition mechanisms of select pathogens of public health importance with host iron homeostasis. Knowledge of these interactions is essential in assessing likely morbidity responses to supplementation.

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  • Iron overload associated with hereditary hemochromatosis has been reported to confer susceptibility to infectious pathogens, such as Yersinia enterocolitica and Vibrio vulnificus.

    “Iron overload associated with hereditary hemochromatosis has been reported to confer susceptibility to infectious pathogens, such as Yersinia enterocolitica and Vibrio vulnificus [101].”

    From The utility of iron chelators in the management of inflammatory disorders (2015) · cites this paper as [101]

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Authors
Doherty, C. P.
Affiliations
Royal Hospital for Children (GB)
Corresponding author
Doherty, Conor P.
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2007-05
Volume
137
Issue
5
Pages
1341-1344
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/137.5.1341
OpenAlex
W2115881233
Cited by
186
References
46
Citations by year
2026: 1 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 17 · 2021: 15 · 2020: 4 · 2019: 11 · 2018: 11 · 2017: 12 · 2016: 8 · 2015: 11 · 2014: 15 · 2013: 12 · 2012: 8
FWCI
6.42
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
Mead Johnson Nutrition
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Physical Sciences › Engineering › Mechanical Engineering › Iron and Steelmaking Processes
Keywords
host-pathogen interaction, iron homeostasis, iron acquisition, iron deficiency, iron overload, iron supplementation, iron deficiency anemia
MeSH terms
Iron Deficiencies, Animals, HIV, Homeostasis, Host-Parasite Interactions, Humans, Immunity, Iron, Plasmodium falciparum, Virulence, Bacterial Physiological Phenomena

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