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Characteristics of an Established Cell Line of Retinoblastoma2
Abstract
The in vitro growth pattern and the morphologic, biochemical, and cytogenetic characteristics of a line of human retinoblastoma cells (Y79) maintained continuously in tissue culture for 36 months are described. This is the first “established” culture to be derived from 45 retinoblastomas which have been in tissue culture for 8 years. The established cell line grew in suspension with clusters of retinoblastoma cells which resembled, by light and electron microscopy, the cells of the original tumor. The cultured tumor cells had ultrastructural characteristics (nuclear membrane infoldings, triple membrane structures, microtubules, large coated vesicles, centrioles, basal bodies, and annulate lamellae) similar to those seen in the original tumor. Cytogenetic studies showed a hypertriploid modal line with variable numbers of minute chromosomes. Although no viral particles were found by electron microscopy, activity of an RNA-directed DNA polymerase with a template specificity like that seen in oncogenic RNA tumor viruses was demonstrated in the cultured cells.
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Cited by
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948
Self-citationVogel, F. (1979) · Human Genetics · doi:10.1007/bf00284597 · Cited by 438
Tan, E., Ding, X.-Q., Saadi, A., Agarwal, N., Naash, M. I., & Al-Ubaidi, M. R. (2004) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.03-1114 · Cited by 345
One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma
Corson, T. W., & Gallie, B. L. (2007) · Genes, Chromosomes and Cancer · doi:10.1002/gcc.20457 · Cited by 278
Metadata
- Authors
- Reid, T. W., Albert, D. M., Rabson, A. S., Russell, P., Craft, J., Chu, E. W., Tralka, T. S., & Wilcox, J. L.
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1974-08
- Volume
- 53
- Issue
- 2
- Pages
- 347-360
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2271332419
- Cited by
- 340
- References
- 0
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Reid, T. W., Albert, D. M., Rabson, A. S., Russell, P., Craft, J., Chu, E. W., Tralka, T. S., & Wilcox, J. L. (1974). Characteristics of an Established Cell Line of Retinoblastoma2. JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/53.2.347
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