The DOI matches its Crossref record.
Cocarcinogenic and Tumor-Promoting Agents in Tobacco Carcinogenesis2
Abstract
A series of 21 tobacco smoke components and related compounds werere applied to mouse skin (50 female ICR/Ha Swiss mice/group) three times weekly with a low dose (5 mug/application) of benzo[a]pyrene (B[a]P). The test compounds were of five classes: aliphatic hydrocarbons, aromatic hydrocarbons, phenols, and long-chain acids and alcohols. The following compounds enhanced remarkably the carcinogenicity of B[a]P: catechol, pyrogallol, decane, undecane, pyrene, benzo[e]pyrene, and fluoranthene. The following compounds inhibited B[a]P carcinogenicity completely: esculin, quercetin, squalene, and oleic acid. Phenol, eugenol, resorcinol, hydroquinone, hexadecane, and limonene partially inhibited B[a]P carcinogenicity. Six of the 21 compounds were also tested as tumor promoters im two-stage carcinogenesis. No direct correlation existed between tumor-promoting activity and cocarcinogenic activity. The cocarcinogens pyrogallol and catechol did not show tumor-promoting activity. Decane, tetradecane, anthralin, and phorbol myristate acetate showed both types of activity. Structure-activity relationships and possible modes of action were described.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Tobacco Smoke Carcinogens and Lung Cancer
Hecht, S. S. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.14.1194 · Cited by 1,976
Oxygen radicals and human disease
CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856
Free-radical chemistry of cigarette smoke and its toxicological implications.
Church, D. F., & Pryor, W. A. (1985) · Environmental Health Perspectives · doi:10.1289/ehp.8564111 · Cited by 1,441
Squalene: A natural triterpene for use in disease management and therapy
Reddy, L. H., & Couvreur, P. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.09.005 · Cited by 397
Monographs on fragrance raw materials
Opdyke, D. L. J. (1981) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(81)90363-1 · Cited by 383
Metadata
- Authors
- Van Duuren, B. L., & Goldschmidt, B. M.
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1976-06
- Volume
- 56
- Issue
- 6
- Pages
- 1237-1242
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2156608990
- Cited by
- 345
- References
- 0
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cocarcinogenic and Tumor-Promoting Agents in Tobacco Carcinogenesis2. https://app.cochat.ai/papers/10.1093/jnci/56.6.1237
- The paper
- Van Duuren, B. L., & Goldschmidt, B. M. (1976). Cocarcinogenic and Tumor-Promoting Agents in Tobacco Carcinogenesis2. JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/56.6.1237
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
