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Photoradiation in the Treatment of Recurrent Breast Carcinoma 2
Abstract
Photoradiation, with the use of hematoporphyrin derivative (Hpd) activated by visible light in the red region of the spectrum, was an effective treatment for controlling local and regional chest wall recurrences of breast carcinoma. With sufficient time between iv injection of the drug and local activation with red light, cutaneous and subcutaneous masses were treated effectively without undue damage to overlying and adjacent skin. This high therapeutic ratio resulted from the ability to Hpd to accumulate and/or to be retained to a higher degree in malignant tissue than in many normal tissues. This technique can be used as a primary treatment or upon tumor recurrence following conventional modalities such as surgery, chemotherapy, and radiation therapy.
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Citations
Cited by
Castano, A. P., Demidova, T. N., & Hamblin, M. R. (2004) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/s1572-1000(05)00007-4 · Cited by 2,052
Porphyrin-based photosensitizers for use in photodynamic therapy
Sternberg, E. D., Dolphin, D., & Brückner, C. (1998) · Tetrahedron · doi:10.1016/s0040-4020(98)00015-5 · Cited by 987
A Review of Progress in Clinical Photodynamic Therapy
Huang, Z. (2005) · Technology in Cancer Research & Treatment · doi:10.1177/153303460500400308 · Cited by 908
Photodynamic therapy (PDT) of malignant tumors
Dougherty, T. J. (1984) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(84)80016-5 · Cited by 296
Current Challenges and Opportunities of Photodynamic Therapy against Cancer
Huis in ‘t Veld, R. V., Heuts, J., Ma, S., Cruz, L. J., Ossendorp, F. A., & Jager, M. J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020330 · Cited by 159
Metadata
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1979-02
- Volume
- 62
- Issue
- 2
- Pages
- 231-7
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W1919763660
- Cited by
- 363
- References
- 0
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Photoradiation in the Treatment of Recurrent Breast Carcinoma 2. (1979). JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/62.2.231
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
