Induction of Retrovirus Particles in Human Testicular Tumor (Tera-1) Cell Cultures: An Electron Microscopic Study 2
Abstract
The Tera-1 and Tera-2 cell lines, established from germ-cell tumors of the human testis, were examined by electron microscopy for particles with the morphology of retroviruses. Extracellular and budding particles were observed at low frequencies only in cultures of Tera-1 cells that had been treated with 5-iodo-2'-deoxyuridine and dexamethasone. No particles were detected in untreated cultures of Tera-1 cells or in any preparations of Tera-2 cells.
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Retrovirus-like particles (RLPs) resemble retroviral vesicles on EM but are non-infectious, are defined by size 90-100 nm and a subset of retroviral proteins, arise by budding from the plasma membrane, and Gag protein may serve as a marker.
“Retrovirus-like Particles (RLPs) are those that resemble retroviral vesicles on EM but are non-infectious because they do not contain the full complement of genes required for cellular entry or viral propagation. These vesicles are typically defined by their size (90-100 nm) and the presence of a subset of retroviral proteins [69-72].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [69]
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Poiesz, B. J., Ruscetti, F. W., Gazdar, A. F., Bunn, P. A., Minna, J. D., & Gallo, R. C. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7415 · Cited by 5,043 · see citing works
Akers, J. C., Gonda, D., Kim, R., Carter, B. S., & Chen, C. C. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1084-8 · Cited by 1,423 · see citing works
“These vesicles are typically defined by their size (90–100 nm) and the presence of a subset of retroviral proteins [69–72].”
Identification of human endogenous retroviruses with complex mRNA expression and particle formation.
Löwer, R., Boller, K., Hasenmaier, B., Korbmacher, C., Müller-Lantzsch, N., Löwer, J., & Kurth, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4480 · Cited by 268 · see citing works
Human RNA “Rumor” Viruses: the Search for Novel Human Retroviruses in Chronic Disease
Voisset, C., Weiss, R. A., & Griffiths, D. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00033-07 · Cited by 157 · see citing works
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Wong, J., Augero, B., Gupta, R., & Morton, D. (1988) · Cancer Immunology Immunotherapy · doi:10.1007/bf00200019 · Cited by 14 · see citing works
- Authors
- Bronson, D. L., Fraley, E. E., Fogh, J., & Kalter, S. S.
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1979-08
- Volume
- 63
- Issue
- 2
- Pages
- 337-9
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2123789811
- Cited by
- 61
- References
- 0
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2017: 2 · 2016: 2 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JNCI Journal of the National Cancer Institute (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Health Sciences › Medicine › Surgery › Testicular diseases and treatments
- Health Sciences › Veterinary › Small Animals › Infectious Diseases and Mycology
- Keywords
- retroviruses, testicular germ cell tumors, extracellular virus particles, 5-iodo-2'-deoxyuridine, dexamethasone, virus induction
- MeSH terms
- Cell Line, Dexamethasone, Humans, Idoxuridine, Inclusion Bodies, Viral, Male, Microscopy, Electron, Neoplasms, Experimental, Teratoma, Testicular Neoplasms, Virus Replication
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