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Cited by 230

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A Human Melanoma Line Heterogeneous With Respect to Metastatic Capacity in Athymic Nude Mice 234

·1984·JNCI: Journal of the National Cancer Institute

Abstract

The ability of the human A375 melanoma cell line to produce experimental and spontaneous in young BALB/c nude mice was examined. Cloned lines, obtained by isolation in semisolid agar, differed significantly (4/10 cloned lines examined, P less than or equal to .005) from the parent tumor line with regard to their ability to form lung tumor nodules subsequent to iv injection. Lines established from such lung tumor nodules were more metastatic than the parent line following both iv and sc injection. These results show that the human melanoma cell line used in these studies contained cells with diverse metastatic potential and suggest that metastasis in the nude mouse results from the preferential selection of metastatic subpopulations.

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Metadata

Venue
JNCI: Journal of the National Cancer Institute
Published
1984-04
Volume
72
Issue
4
Pages
913-7
ISSN
  • 0027-8874 (ISSN-L)
  • 1460-2105
OpenAlex
W1907082099
Cited by
230
References
0
FWCI
4.93
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A Human Melanoma Line Heterogeneous With Respect to Metastatic Capacity in Athymic Nude Mice 234. https://app.cochat.ai/papers/10.1093/jnci/72.4.913
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A Human Melanoma Line Heterogeneous With Respect to Metastatic Capacity in Athymic Nude Mice 234. (1984). JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/72.4.913

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.