The DOI matches its Crossref record, with a small difference in title or year.
Pleural Carcinogenic Potency of Mineral Fibers (Asbestos, Attapulgite) and Their Cytotoxicity on Cultured Cells 2
Abstract
The carcinogenicity of several samples of mineral fibers was tested following injection of 20 mg in the pleural cavity of noninbred Sprague-Dawley rats. Three samples of chrysotile asbestos (mean length: 3.2, 2.1, and 1.2 micron) induced mesotheliomas at a rate of 48, 52, and 19%, respectively. The first sample was acid leached prior to intrapleural injection; in that group, the percentage of mesotheliomas was reduced to 25%. Treatment with amosite and crocidolite resulted in the occurrence of 57 and 56% of mesotheliomas. Acid-treatment of amphiboles did not significantly modify the percentage of mesotheliomas. When the Stanton's fiber dimensions were taken into consideration to correlate with mesothelioma incidence, the observed number of mesotheliomas in the chrysotile-treated animals was much lower than that expected, suggesting that other fiber parameters (chemistry, physicochemistry) play a role in the carcinogenicity. Attapulgite fibers (mean length: 0.77 micron) did not induce tumor, and the mean survival time was of the same order as that observed in the control groups. The injection of quartz resulted in no mesothelioma but did result in 6 malignant histiocytic lymphomas (17%) and 2 malignant schwannomas (6%). In vitro experiments did not show strong correlation between cytotoxicity and the carcinogenic potency of these minerals, but the qualitative cellular responses might give some indications on the fiber's potency. In addition, the in vitro effects of the fibers…
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In the citing paper
“Indeed the dimensional characteristics of asbestos fibers are an important parameter influencing carcinogenicity in animals, but this parameter does not fully explain the potency.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [74]
In the citing paper
“The important role of fibers corresponding to Stanton’s criteria (L > 8 μm; d ≤ 0.25 μm) has been evidenced in other reports where asbestos fibers were injected in the pleural cavity [74-76].”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [74]
In the citing paper
“The results showed that the physico-chemical modification of the fibers influenced the relationship between the number of fibers and their potential carcinogenicity.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [74]
Citations
Cited by
Boulanger, G., Andujar, P., Pairon, J.-C., Billon-Galland, M.-A., Dion, C., Dumortier, P., Brochard, P., Sobaszek, A., Bartsch, P., Paris, C., et al. (2014) · Environmental Health · doi:10.1186/1476-069x-13-59 · Cited by 176
Self-citationRole of Mutagenicity in Asbestos Fiber-Induced Carcinogenicity and Other Diseases
Huang, S. X. L., Jaurand, M.-C., Kamp, D. W., Whysner, J., & Hei, T. K. (2011) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937404.2011.556051 · Cited by 163
Yegles, M., Saint-Etienne, L., Renier, A., Janson, X., & Jaurand, M.-C. (1993) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/9.2.186 · Cited by 62
Favero-Longo, S. E., Turci, F., Tomatis, M., Castelli, D., Bonfante, P., Hochella, M. F., Piervittori, R., & Fubini, B. (2005) · Journal of Environmental Monitoring · doi:10.1039/b507569f · Cited by 62
A Biomimetic Approach to the Chemical Inactivation of Chrysotile Fibres by Lichen Metabolites
Turci, F., Favero‐Longo, S. E., Tomatis, M., Martra, G., Castelli, D., Piervittori, R., & Fubini, B. (2007) · Chemistry – A European Journal · doi:10.1002/chem.200600991 · Cited by 49
Metadata
- Venue
- JNCI: Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1987-10
- ISSN
- 1460-2105
- Cited by
- 0
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: Pleural Carcinogenic Potency of Mineral Fibers (Asbestos, Attapulgite) and Their Cytotoxicity on Cultured Cells 2. https://app.cochat.ai/papers/10.1093/jnci/79.4.797
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- Pleural Carcinogenic Potency of Mineral Fibers (Asbestos, Attapulgite) and Their Cytotoxicity on Cultured Cells 2. (1987). JNCI: Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/79.4.797
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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