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Effects of Tamoxifen on Spinal Bone Density in Women With Breast Cancer

Turken, S., Siris, E., Seldin, D., Flaster, E., Hyman, G., Lindsay, R.·1989·JNCI Journal of the National Cancer Institute

Abstract

Bone densitometry (L2-L4) was performed on 10 postmenopausal women with breast cancer after 0, 6, and 12 months of tamoxifen treatment; the results were compared with data from 10 normal controls. The patients and controls differed significantly at 6 (P less than .05) and 12 (P less than .003) months. The tamoxifen group showed a nonsignificant mean gain in bone mineral density after 6 and 12 months of treatment (+0.024 +/- 0.014 and +0.022 +/- 0.018 g/cm2, respectively), whereas the controls showed a nonsignificant mean loss of bone mass at 6 months (-0.012 +/- 0.018 g/cm2) and a statistically significant loss of bone density after 12 months (-0.024 +/- 0.01 g/cm2). These preliminary data suggest that tamoxifen use is associated with preservation of bone mass during the first year of treatment.

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Metadata

Authors
Turken, S., Siris, E., Seldin, D., Flaster, E., Hyman, G., & Lindsay, R.
Venue
JNCI Journal of the National Cancer Institute
Published
1989-07-19
Volume
81
Issue
14
Pages
1086-1088
ISSN
  • 0027-8874 (ISSN-L)
  • 1460-2105
OpenAlex
W2102667542
Cited by
194
References
0
FWCI
18.60
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Effects of Tamoxifen on Spinal Bone Density in Women With Breast Cancer. https://app.cochat.ai/papers/10.1093/jnci/81.14.1086
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Turken, S., Siris, E., Seldin, D., Flaster, E., Hyman, G., & Lindsay, R. (1989). Effects of Tamoxifen on Spinal Bone Density in Women With Breast Cancer. JNCI Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/81.14.1086

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