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Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors
Abstract
Retroviral vectors constructed to contain the herpes simplex virus thymidine kinase (HSV-TK) gene were used for transduction of this gene into murine sarcoma and lymphoma cells to yield sublines susceptible in vitro to the cytotoxicity of ganciclovir, a drug specifically activated by HSV-TK. In vivo, ganciclovir induced complete, durable regressions in most mice bearing transplanted HSV-TK-positive sarcomas; its efficacy against lymphomas was only marginal, possibly because of their greater instability of gene expression. The results imply the potential value of an anticancer strategy entailing the prophylactic use of retroviral vectors to create tissue mosaicism for drug sensitivity.
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Cited by
Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
Ram, Z., Culver, K. W., Oshiro, E. M., Viola, J. J., DeVroom, H. L., Otto, E., Long, Z., Chiang, Y., McGarrity, G. J., Muul, L. M., et al. (1997) · Nature Medicine · doi:10.1038/nm1297-1354 · Cited by 668
Wirth, T., Parker, N., & Ylä-Herttuala, S. (2013) · Gene · doi:10.1016/j.gene.2013.03.137 · Cited by 607
Puche, J. E., Lee, Y. A., Jiao, J., Aloman, C., Fiel, M. I., Muñoz, U., Kraus, T., Lee, T., Yee, H. F., & Friedman, S. L. (2013) · Hepatology · doi:10.1002/hep.26053 · Cited by 136
Gene Therapy for Human Malignant Brain Tumors
Rainov, N. G., & Ren, H. (2003) · The Cancer Journal · doi:10.1097/00130404-200305000-00006 · Cited by 48
Metadata
- Authors
- Moolten, F. L., & Wells, J. M.
- Venue
- JNCI Journal of the National Cancer Institute
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-02-21
- Volume
- 82
- Issue
- 4
- Pages
- 297-300
- ISSN
- 0027-8874 (ISSN-L)
- 1460-2105
- OpenAlex
- W2148769388
- Cited by
- 507
- References
- 0
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors. https://app.cochat.ai/papers/10.1093/jnci/82.4.297
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- Moolten, F. L., & Wells, J. M. (1990). Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors. JNCI Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/82.4.297
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
